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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 3 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 4 | Solving sparse non-negative tensor equations: algorithms and applications显示文摘我们为解决在多维的网络由询问搜索和社区发现从象信息检索那样的数据采矿应用程序产生的一套稀少的非否定的张肌方程(multivariate 多项式系统) 学习反复的方法。由使用稀少、非否定的张肌结构,我们为解决张肌方程开发 Jacobi 和 Gauss-Seidel 方法。有向量的张肌的增加在这些反复的方法的每次重复被要求,费用在稀少的张肌每重复取决于非零的数字。我们在合适的条件下面显示出 Jacobi 和 Gauss-Seidel 方法的线性集中,并且因此,稀少的非否定的张肌方程的集合能很高效地被解决。由在多维的网络的询问搜索和社区发现的信息检索上的试验性的结果被介绍说明张肌方程的应用程序和建议方法的有效性。 | Xutao LI Michael K. NG | 2015 | Frontiers of Mathematics in China2015，10，3： | 10 |
| 5 | Ileal-anal pouches: A review of its history, indications, and complications显示文摘The ileal pouch anal anastomosis(IPAA)has revolutionised the surgical management of ulcerative colitis(UC)and familial adenomatous polyposis(FAP).Despite refinement in surgical technique(s)and patient selection,IPAA can be associated with significant morbidity.As the IPAA celebrated its 40th anniversary in 2018,this review provides a timely outline of its history,indications,and complications.IPAA has undergone significant modification since 1978.For both UC and FAP,IPAA surgery aims to definitively cure disease and prevent malignant degeneration,while providing adequate continence and avoiding a permanent stoma.The majority of patients experience long-term success,but“early”and“late”complications are recognised.Pelvic sepsis is a common early complication with far-reaching consequences of long-term pouch dysfunction,but prompt intervention(either radiological or surgical)reduces the risk of pouch failure.Even in the absence of sepsis,pouch dysfunction is a longterm complication that may have a myriad of causes.Pouchitis is a common cause that remains incompletely understood and difficult to manage at times.10%of patients succumb to the diagnosis of pouch failure,which is traditionally associated with the need for pouch excision.This review provides a timely outline of the history,indications,and complications associated with IPAA.Patient selection remains key,and contraindications exist for this surgery.A structured management plan is vital to the successful management of complications following pouch surgery. | Kheng-Seong Ng Simon Joseph Gonsalves Peter Michael Sagar | 2019 | World Journal of Gastroenterology2019，25，31： | 6 |
| 6 | A Coordinate Gradient Descent Method for Nonsmooth Nonseparable Minimization显示文摘This paper presents a coordinate gradient descent approach for minimizing the sum of a smooth function and a nonseparable convex function.We find a search direction by solving a subproblem obtained by a second-order approximation of the smooth function and adding a separable convex function.Under a local Lipschitzian error bound assumption,we show that the algorithm possesses global and local linear convergence properties.We also give some numerical tests(including image recovery examples) to illustrate the efficiency of the proposed method. | Zheng-Jian Bai Michael K. Ng Liqun Qi | 2009 | Numerical Mathematics(Theory,Methods and Applications)2009，2，4： | 6 |
| 7 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 8 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 9 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 5 |
| 10 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 11 | EFFICIENT BOX-CONSTRAINED TV-TYPE-l^1 ALGORITHMS FOR RESTORING IMAGES WITH IMPULSE NOISE显示文摘 | Liyan Ma Michael K. Ng Jian Yu Tieyong Zeng | 2013 | Journal of Computational Mathematics2013，31，3： | 4 |
| 12 | Effects of nanotopography on stem cell phenotypes显示文摘Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues.In the stem cell niche,stem cell-extracellular matrix(ECM)interactions are crucial for different cellular functions,such as adhesion,proliferation,and differentiation.Recently, in addition to chemical surface modifications,the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs.This review describes the influence of nanotopography on stem cell phenotypes. | Rajeswari Ravichandran Clarisse CH Ng Casey K Chan Michael Raghunath Seeram Ramakrishna | 2009 | World Journal of Stem Cells2009，1，1： | 3 |
| 13 | Spectral Analysis for HSS Preconditioners显示文摘In this paper,we are interested in HSS preconditioners for saddle point lin- ear systems with a nonzero(2,2)-th block.We study an approximation of the spectra of HSS preconditioned matrices and use these results to illustrate and explain the spectra obtained from numerical examples,where the previous spectral analysis of HSS precon- ditioned matrices does not cover. | Lung Chak Chan Michael K. Ng Nam Kiu Tsing | 2008 | Numerical Mathematics(Theory,Methods and Applications)2008，1，1： | 3 |
| 14 | Preface显示文摘为“计算数学的杂志”的 2007 年 9 月期的一篇前言被介绍。 | Chan, Raymond Wai-ki Ching Ng, Michael | 2007 | Journal of Computational Mathematics2007，25，5： | 3 |
| 15 | A MULTIPLE INTELLIGENT AGENT SYSTEM FOR CREDIT RISK PREDICTION VIA AN OPTIMIZATION OF LOCALIZED GENERALIZATION ERROR WITH DIVERSITY显示文摘公司破产每年在损失花费了十亿美元到银行。因此承认风险预言是一个银行的贷款赞同决定过程的关键部分。为信用风险预言的传统的金融模型为 describingtoday 在金融健康和一个公司的潜在的破产之间的复杂关系不再是足够的。Inthis 工作,一个多重分类器系统(在一个多重聪明的代理人系统嵌入) 被建议预言一个公司的金融健康。在我们的模型,每个单个代理人(分类器) 基于公司的仅仅偏爱的信息在信用风险的可能性上做预言。每代理人是一位专家,但是限制了知识(由特征代表了) 关于公司。所有代理人的决定一起被联合形成最后的信用风险预言。实验证明我们的模型用 benchmarking Compustat 美国公司数据集超过另外的存在方法。 | Daniel S. YEUNG Wing W. Y. NG Aki P. F. CHAN Patrick P. K. CHAN Michael FIRTH Eric C. C. TSANG | 2007 | Journal of Systems Science and Systems Engineering2007，16，2： | 2 |
| 16 | Role of β-microseminoprotein from prostate cancer initiationto recurrence: A mini-review显示文摘Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe disease. | Nishi Karunasinghe Karen Bishop Pamela Murray Yuanye Xu Megan Goudie Lance Ng Shuotun Zhu Dug Yeo Han Lynnette R Ferguson Jonathan Masters Benji Benjamin Michael Holmes | 2014 | World Journal of Clinical Urology2014，3，1： | 2 |
| 17 | Efficacy and tolerability of vardenafil in Asian men with erectile dysfunction显示文摘瞄准:评估功效和 vardenafil 的 toler 能力,一个 phosphodiesterase type-5 (PDE-5 ) 禁止者,在有可勃起的机能障碍(编辑) 的亚洲种族的人。方法:在这未来,双窗帘,多民族的学习,亚洲人被使随机化收到 vardenafil (10 mg ) 或安慰剂(4:1 比率) 12 个星期。主要功效变量是可勃起的功能的国际索引可勃起的功能领域(IIEF-EF ) ,和性相遇侧面(9 月) 与穿入和交际结束有关询问。重要吝啬的改进在所有三项措施被要求显示出 vardenafil 处理的积极好处。第二等的功效变量在勃起改进上包括了全球评价问题(GAQ ) 。结果:最少平方的吝啬的基线 IIEF-EF 领域分数(vardenafil 14.6,安慰剂 13.4 ) 与在 12 个星期以后的中等编辑一致, vardenafil 处理与安慰剂相比在 IIEF-EF 领域分数从基线与重要增加被联系(22.4 对 14.3;P <
0.001 ) 。Vardenafil 在吝啬的成功为 SEP-2 评估的最少的广场(LS ) 从基线与重要改进被联系(vardenafil 82.2 对安慰剂 43.6;P <
0.001 ) 并且 SEP-3 (vardenafil 66.1 对安慰剂 24.0;P <
0.001 ) 。积极 GAQ 回答被 81.8% vardenafil 接受者对 24.3% 安慰剂接受者报导。不利事件被 25.4% vardenafil 组,报导温和、短暂的多数。结论:Vardenafil (10 mg ) 是为在亚洲男人的中等编辑的一个高度有效、容忍得好的处理。这些结果增加在耐心的人口的一个范围为编辑的治疗表明 vardenafil 的安全和功效的数据的增加的数量。 | Hui Meng Tan Chong Min Chin Chong Beng Chua Edsal Gatchalian Apichat Kongkanand Clarence Lei Chang Moh Foo Cheong Ng Krisada Ratana-Olarn Dennis Serrano Akmal Taher Ismail Tambi Anupan Tantiwong Michael Wong Yuet Chen Wai-Chun Yip | 2008 | Asian Journal of Andrology2008，10，3： | 2 |
| 18 | Alternating Minimization Method for Total Variation Based Wavelet Shrinkage Model显示文摘In this paper,we introduce a novel hybrid variational model which generalizes the classical total variation method and the wavelet shrinkage method.An alternating minimization direction algorithm is then employed.We also prove that it converges strongly to the minimizer of the proposed hybrid model.Finally,some numerical examples illustrate clearly that the new model outperforms the standard total variation method and wavelet shrinkage method as it recovers better image details and avoids the Gibbs oscillations. | Tieyong Zeng Xiaolong Li Michael Ng | 2010 | Communications in Computational Physics2010，8，10： | 2 |
| 19 | BLOCK-TRIANGULAR PRECONDITIONERS FOR SYSTEMS ARISING FROM EDGE-PRESERVING IMAGE RESTORATION显示文摘信号和图象恢复问题被最小化由 l 组成的一个费用函数经常解决[2 ] 数据忠实术语和一个规则化术语。我们考虑凸、保存边的规则化功能的一个班。在是的特定的、一半二次的规则化,一个定点重复方法通常被采用解决这个问题。这份报纸的主要目的是由使用牛顿方法与一半二次的规则化技术解决上面描述的信号和图象恢复问题。在牛顿方法的每次重复,牛顿方程是一个对称的积极明确的系数矩阵的线性方程的一个结构化的系统,并且可以被 preconditioned 高效地解决结合与修改的块 SSOR preconditioner 加速的坡度方法。我们的试验性的结果证明修改 block-SSOR preconditioned 结合坡度方法为进一步改进一半二次的规则化途径的数字表演可行、有效。[从作者抽象] | Zhong-Zhi Bai Yu-Mei Huang Michael K. Ng | 2010 | Journal of Computational Mathematics2010，28，6： | 2 |
| 20 | Reduced accumulation of specific microRNAs in colorectal neo?plasia显示文摘 | MICHAEL MZ SM OC VAN HOLST PELLEKAAN NG | 2003 | Mol Cancer Res2003，1，： | 1 |
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