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| 1 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 2 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 3 | Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C显示文摘 | Roy L. Hawke Sarah J. Schrieber Tedi A. Soule Zhiming Wen Philip C. Smith Rajender K. Reddy Abdus S. Wahed Steven H. Belle Nezam H. Afdhal Victor J. Navarro Josh Berman Qi-Ying Liu Edward Doo Michael W. Fried | 2010 | Journal of Clinical Pharmacology2010，，4： | 2 |
| 4 | Isolation of a Δ6-desaturase gene from the cyanobacterium Synechocystis sp. strain PCC 6803 by gain-of-function expression in Anabaena sp.strain PCC 7120显示文摘 | Avutu S. Reddy Michael L. Nuccio Lisa M. Gross Terry L. Thomas | 1993 | Plant Molecular Biology1993，，2： | 1 |
| 5 | EUS-guided trucut biopsy in establishing autoimmune pancreatitis as the cause of obstructive jaundice显示文摘 | Michael J. Levy Raghuram P. Reddy Maurits J. Wiersema Thomas C. Smyrk Jonathan E. Clain Gavin C. Harewood Randall K. Pearson Elizabeth Rajan Mark D. Topazian Tony E. Yusuf Suresh T. Chari Bret T. Petersen | 2005 | Gastrointestinal Endoscopy2005，，3： | 1 |
| 6 | Effects of Isoflurane on Coronary Blood Flow Velocity in Young, Old and ApoE ?/? Mice Measured by Doppler Ultrasound显示文摘 | Craig J. Hartley Anilkumar K. Reddy Sridhar Madala Lloyd H. Michael Mark L. Entman George E. Taffet | 2007 | Ultrasound in Medicine & Biology2007，，4： | 1 |
| 7 | Comparison of the Etest and the NCCLS-approved agar dilution method to detect metronidazole and clarithromycin resistant Helicobacter pylori显示文摘 | Michael S Osato Rita Reddy Siddartha G Reddy Rebecca L Penland David Y Graham | 2001 | International Journal of Antimicrobial Agents2001，，1： | 1 |
| 8 | X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and Ravaz index显示文摘Annual rings from 30 year old vines in a California rootstock trial were measured to determine the effects of 15 different rootstocks on Chardonnay and Cabernet Sauvignon scions.Viticultural traits measuring vegetative growth,yield,berry quality,and nutrient uptake were collected at the beginning(1995 to 1999)and end(2017 to 2020)of the lifetime of a vineyard initially planted in 1991 and removed in 2021.X-ray Computed Tomography(CT)was used to measure ring widths in 103 vines.Ring width was modeled as a function of ring number using a negative exponential model.Early and late wood ring widths,cambium width,and scion trunk radius were correlated with 27 traits.Modeling of annual ring width shows that scions alter the width of the first rings but that rootstocks alter the decay of later rings,consistently shortening ring width throughout the lifetime of the vine.Ravaz index,juice pH,photosynthetic assimilation and transpiration rates,and instantaneous water use efficiency are correlated with scion trunk radius.Ultimately,our research indicates that rootstocks modulate secondary growth over years,altering physiology and agronomic traits.Rootstocks act in similar but distinct ways from climate to modulate ring width,which borrowing techniques from dendrochronology,can be used to monitor both genetic and environmental effects in woody perennial crop species. | ZoëMigicovsky Michelle Y.Quigley Joey Mullins Tahira Ali Joel F.Swift Anita Rose Agasaveeran Joseph D.Dougherty Brendan Michael Grant Ilayda Korkmaz Maneesh Reddy Malpeddi Emily L.McNichol Andrew W.Sharp Jackie L.Harris Danielle R.Hopkins Lindsay M.Jordan Misha T.Kwasniewski R.Keith Striegler Asia L.Dowtin Stephanie Stotts Peter Cousins Daniel H.Chitwood | 2023 | Horticulture Research2023，10，1： | 1 |
| 9 | Liver transplantation for hepatocellular carcinoma validation of present selection criteria in predicting outcome显示文摘 | Kirti Shetty Kate Timmins Colleen Brensinger Emma E. Furth Sushil Rattan Weijing Sun Mark Rosen Michael Soulen Abraham Shaked K. Rajender Reddy Kim M. Olthoff | 2004 | Liver Transpl2004，，7： | 1 |
| 10 | Osmotic Effect of Honey on Growth and Viability of Helicobacterpylori显示文摘 | Michael S. Osato Siddharta G. Reddy David Y. Graham | 1999 | Digestive Diseases and Sciences1999，，3： | 1 |
| 11 | Efficacy and safety of pegylated (40-kd) interferon α-2a compared with interferon α-2a in noncirrhotic patients with chronic hepatitis C显示文摘 | K.Rajender Reddy Teresa L. Wright Paul J. Pockros Mitchell Shiffman Gregory Everson Robert Reindollar Michael W. Fried Preston P. Purdum Donald Jensen Coleman Smith William M. Lee Thomas D. Boyer Amy Lin Simon Pedder Jean DePamphilis | 2001 | Hepatology2001，，2： | 1 |
| 12 | Trauma-Induced Cell Swelling in Cultured Astrocytes显示文摘 | Arumugam R. Jayakumar K.V. Rama Rao Kiran S. Panickar M. Moriyama P.V.B. Reddy Michael D. Norenberg | 2008 | Journal of Neuropathology and Experimental Neurology2008，，： | 1 |
| 13 | Brain Edema in Acute Liver Failure显示文摘 | Kakulavarapu V. Rama Rao Pichili V.B. Reddy Xiaoying Tong Michael D. Norenberg | 2010 | The American Journal of Pathology2010，，3： | 1 |
| 14 | Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection显示文摘 | FRIED MICHAEL W SHIFFMAN MITCHELL L REDDY K RAJENDER | 2002 | N Engl J Med2002，347，13： | 1 |
| 15 | Simultaneous Resections of Colorectal Cancer and Synchronous Liver Metastases: A Multi-institutional Analysis显示文摘 | Srinevas K. Reddy MD Timothy M. Pawlik MD MPH Daria Zorzi MD Ana L. Gleisner MD Dario Ribero MD Lia Assumpcao MD Andrew S. Barbas BS Eddie K. Abdalla MD Michael A. Choti MD Jean-Nicolas Vauthey MD Kirk A. Ludwig MD Christopher R. Mantyh MD Michael A. Mor | 2007 | Annals of Surgical Oncology2007，，12： | 1 |
| 16 | Development of a general purpose thermal-hydraulic software and its application to fuel injection systems显示文摘 | Babajide Kolade Michael E Boghosian P S Reddy Shawn Gallagher | 2003 | SAE2003，，： | 1 |
| 17 | Marginal Recurrence Requiring Salvage Radiotherapy After Stereotactic Body Radiotherapy for Spinal Metastases显示文摘 | Shlomo A. Koyfman Toufik Djemil Michael J. Burdick Neil Woody Ehsan H. Balagamwala Chandana A. Reddy Lilyana Angelov John H. Suh Samuel T. Chao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，1： | 1 |
| 18 | Reoperation following Pancreaticoduodenectomy显示文摘 | J. R. Reddy R. Saxena R. K. Singh B. Pottakkat A. Prakash A. Behari A. K. Gupta V. K. Kapoor Michael Hünerbein | 2012 | International Journal of Surgical Oncology2012，，： | 1 |
| 19 | Timing of Multimodality Therapy for Resectable Synchronous Colorectal Liver Metastases: A Retrospective Multi-Institutional Analysis显示文摘 | Srinevas K. Reddy Daria Zorzi Ying Wei Lum Andrew S. Barbas Timothy M. Pawlik Dario Ribero Eddie K. Abdalla Michael A. Choti Clinton Kemp Jean-Nicolas Vauthey Michael A. Morse Rebekah R. White Bryan M. Clary | 2009 | Annals of Surgical Oncology2009，，7： | 1 |
| 20 | Safety Profile of Boceprevir and Telaprevir in Chronic Hepatitis C: Real-World Experience From HCV-TARGET显示文摘 | Stuart C. Gordon Andrew J. Muir Joseph K. Lim Brian Pearlman Curtis K. Argo Ananthakrishnan Ramani Benedict Maliakkal Imtiaz Alam Thomas G. Stewart Monika Vainorius Joy Peter David R. Nelson Michael W. Fried K. Rajender Reddy | 2014 | Journal of Hepatology2014，，： | 1 |
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