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| 1 | Anterior resection for rectal carcinoma-risk factors for anastomotic leaks and strictures显示文摘AIM:To determine the incidence and factors responsible for anastomotic leaks and stricture following anterior resection(AR)and its subsequent management.METHODS:Retrospective analysis of data from 108 patients with rectal carcinoma who underwent AR or low anterior resection(LAR)to identify the various preoperative,operative,and post operative factors that might have influence on anastomotic leaks and strictures.RESULTS:There were 68 males and 40 females with an average of 47 years(range 21-75 years).The median distance of the tumor from the anal verge was 8 cm(range 3-15 cm).Sixty(55.6%)patients underwent handsewn anastomosis and 48(44.4%)were stapled.The median operating time was 3.5 h(range2.0-7.5 h).Sixteen(14.6%)patients had an anastomotic leak.Among these,11 patients required reexploration and five were managed expectantly.The anastomotic leak rate was similar in patients with and without diverting stoma(8/60,13.4%with stoma and 8/48;16.7%without stoma).In 15(13.9%)patients,resection margins were positive for malignancy.Ninteen(17.6%)patients developed anastomotic strictures at a median duration of 8 mo(range 3-20 mo).Among these,15 patients were successfully managed with per-anal dilatation.On multivariate analysis,advance age(>60 years)was the only risk factor for anastomotic leak(P=0.004).On the other hand,anastomotic leak(P=0.00),mucin positive tumor(P =0.021),and lower rectal growth(P=0.011)were found as risk factors for the development of an anastomotic stricture.CONCLUSION:Advance age is a risk factor for an anastomotic leak.An anastomotic leak,a mucin-secreting tumor,and lower rectal growth predispose patients to develop anastomotic strictures. | Ashok Kumar Ram Daga Paari Vijayaragavan Anand Prakash Rajneesh Kumar Singh Anu Behari Vinay K Kapoor Rajan Saxena | 2011 | World Journal of Gastroenterology2011，17，11： | 28 |
| 2 | The Receptor-Like Cytoplasmic Kinase (OsRLCK) Gene Family in Rice: Organization, Phylogenetic Relationship, and Expression during Development and Stress显示文摘在植物的像受体的细胞质的 kinases (RLCK ) 属于像受体的 kinases (RLK ) 的超级家庭。这些蛋白质在 kinase 领域显示出相同到 RLK,但是缺乏 transmembrane 领域。一些从植物的机能上地描绘的 RLCK 被显示了在开发和压力回答起作用。以前, 149 和 187 RLCK 编码基因分别地从 Arabidopsis 和米饭被识别。由使用唔基于领域结构和种系发生的关系,我们从米饭识别了 379 OsRLCKs。OsRLCKs 在米饭的所有 12 个染色体上被散布,一些成员位于复制 chromosomal 片断。几 OsRLCKs 也可能经历其他的拼接,仅仅在基因形式的一些有的证据当模特儿。理解他们的可能的函数,表达式模式在用 microarray 和基于 MPSS 的数据的植物、繁殖的开发以及不能生活、关於生命的应力的里程碑阶段期间被分析。为选择很少介绍基因的实时基于 PCR 的表示证实了 microarray 分析的结果。在开发和应力期间为 OsRLCKs 的多数观察的微分表示模式在米饭在多样的功能建议他们的参与。压力应答的 OsRLCKs 的多数也被发现在不能生活的压力 QTL 的印射的区域以内局部性。这研究的结果将在选择器官 / 发展帮助为功能的确认研究上演特定的 OsRLCK 基因 / 目标。 | Shubha Vij Jitender Giri Prasant Kumar Dansana Sanjay Kapoor Akhilesh K. Tyagi | 2008 | Molecular Plant2008，1，5： | 21 |
| 3 | Tanshinone ⅡA:a Potent,Natural Anti-carcinogenic Agent for the Management of Systemic Malignancies显示文摘To the editor:I read with great interest the recent article by Li,et al.The authors have clearly shown that tanshinoneⅡA inhibits myocardial cell hypertrophy induced by angiotensinⅡby inhibiting p-ERK1/2 expression.Interestingly,tanshinoneⅡA also has potent anti-carcinogenic properties.As a result,tanshinoneⅡA is rapidly emerging as an agent with considerable promise in the field of oncology. | Shailendra Kapoor | 2009 | Chinese Journal of Integrative Medicine2009，15，2： | 16 |
| 4 | 身体功能恢复的脑卒中患者仍存在认知障碍、抑郁症状和重返社会障碍显示文摘脑卒中后的功能预后往往通过改良的Rankin量表进行评估,仅对主要日常生活活动能力进行评估。但脑卒中患者可能在重新融入社会生活的时候遇到困难,心理上感觉孤立,生活质量差,即便是身体功能完全恢复的患者也存在上述问题。 | Kapoor A Lanctt KL Bayley M Kiss A Herrmann N Murray BJ Swartz RH 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 16 |
| 5 | Contrast-free air cholangiography-assisted unilateral plastic stenting in malignant hilar biliary obstruction显示文摘BACKGROUND:Endoscopic palliation in malignant hilar biliary obstruction requires endoscopic retrograde cholangiopancreatography (ERCP),whereas contrast injection leads to cholangitis.Contrast-free metal stenting with or without magnetic resonance cholangiopancreatography (MRCP) has shown encouraging results,but MRCP and metal stents are costly.There have been no reports on the use of air cholangiography.METHODS:We prospectively evaluated the role of air cholangiography-assisted unilateral plastic stenting in 10 patients with type Ⅱ malignant hilar biliary obstruction.A retrospectively analysed group of 10 patients treated with contrast-free unilateral metal stenting served as historical controls.RESULTS:Ten patients with unresectable type Ⅱ malignant hilar biliary obstruction were studied.Air cholangiography detected type Ⅱ obstruction in all patients,similar to MRCP.The patients underwent unilateral stenting.Successful endoscopic drainage was achieved in all patients.The mean patency of the stent was 95.8±17.5 days in the study group and 143.9±115.1 days in the control group (P=0.20).The mean survival was 121.8±41.6 days in the study group and 154.9±122.5 days in the control group (P=0.42).KaplanMeier analysis showed an estimated median survival of 100:95% CI (65.9,134.1) days in the study group and 98:95% CI (84.1,111.9) days in the control group (P=0.62).Cholangitis occurred in none of the patients and there were no 30-day deaths nor major complications.Air cholangiographyassisted unilateral plastic stenting was cheaper than contrastfree unilateral metal stenting.CONCLUSION:Air cholangiography-assisted unilateral plastic stenting is as safe and effective as contrast-free unilateral metal stenting in type Ⅱ malignant hilar biliary obstruction for palliating patients,but it is cheaper. | Virendra Singh Gurpreet Singh Vikas Gupta Rajesh Gupta Rakesh Kapoor | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 7 |
| 6 | Management of constipation in the elderly: Emerging therapeutic strategies显示文摘A number of new, novel strategies for managing constipation in the elderly have emerged over the past few years. Prucalopride is one such new agent that is highly effi cacious in managing chronic constipation. In fact, Camilleri et al in a recent study reported that the average number of bowel movements increased by at least one in nearly 47% of the patients who were administered a dose of 4 mg. Lubiprostone is another new agent recently approved by the FDA that shows efficacy in managing the symptoms of constipation. Neostigmine has also been successfully used for the management of recalcitrant constipation. Most of these studies have used subcutaneous neostigmine. Symbiotic yogurt containig components, such as Bifidobacterium and fructoligosaccharide, have also been recently shown to be highly effective in improving symptoms of constipation. Elderly patients especially those in hospices and nursing homes are often on opiods for pain management. Constipation secondary to opioid use is extremely common in nursing homes. Subcutaneous methylnaltrexone has recently been shown to be highly effective in the management of opioid-related constipation, and was recently approved by the FDA. Sacral nerve stimulation is another emerging strategy. A recent analysis by Mowatt et al supports the eff icacy of this technique. Botulinum toxin is another agent that has already been successfully used for the management of chronic, refractory constipation in children and may be very effective for elderly constipation. Further larger studies are needed to confi rm the fi ndings noted in these studies. Constipation is clearly a major issue in the elderly and these new, emerging strategies will hopefully improve the quality of life and relieve the symptoms of constipation in this population. | Shailendra Kapoor | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 7 | nm23H1 expression and its role in the evolution of non-gastrointestinal malignancies显示文摘The role of nm23H1 genetic instability is not limited to gastrointestinal malignancies.A similar close relationship exists between nm23H1 genetic instability and other non gastrointestinal systemic malignancies.For instance,in oral malignant melanomas with lymphoid metastasis,the nm23H1 expression is significantly lower in contrast to tumors with no lymphoid metastasis.Similarly,increased metastasis is seen in non small cell lung cancers following down regulation of nm23H1 in conjunction with KAI-1 down regulation. There is an inverse relationship between tumor stage and metastasis and nm23H1 expression in individuals with prostate carcinomas and a similar relationship exists between microsatellite instability of the nm23H1 gene and ovarian carcinogenesis.For instance,nearly 70.5%of stageⅠ-Ⅱovarian tumors express nm23H1 in sharp contrast to only 25%of stageⅢ-Ⅳovarian tumors.As is clearly evident,nm23H1 has a major role in gastrointestinal and non-gastrointestinal carcinogenesis.The coming few years will hopefully see the development of new strategies by virtue of which we can alter nm23H1 expression and thus decrease the risk of metastasis in malignant tumors. | Shailendra Kapoor | 2009 | World Journal of Gastroenterology2009，15，4： | 5 |
| 8 | Beyond pancreatic carcinoma:The close relationship between survivin levels and prognosis in systemic malignancies显示文摘I read with great interest the recent article by Liu and Wang in a recent issue of your esteemed journal. The article is highly thought provoking. Interestingly, the past few years have seen a number of studies that have established a close relationship between survivin expression and tumor prognosis in systemic malignancies besides pancreatic carcinomas. For instance, a poor prognosis is seen in patients with bladder carcinomas which exhibit survivin over expression. A higher recurrence rate is seen following radio-chemotherapy in bladder carcinomas which exhibit increased survivin expression. Similarly, up regulation of survivin expression is seen in non-small cell lung cancers. In fact, Yamashita et al have shown that when used in combination with p53AIP1, survivin is a powerful prognostic indicator in non-small cell lung carcinomas. Similarly in breast carcinomas, increased survivin expression is more commonly seen in estrogen receptor negative carcinomas and is associated with a poor overall prognosis. | Shailendra Kapoor | 2012 | World Journal of Clinical Oncology2012，3，5： | 4 |
| 9 | Opioid/naloxone prolonged release combinations for opioid induced constipation显示文摘I read with great interest the recent article by Chen et al in a recent issue of your esteemed journal.The article is highly thought provoking.One emerging therapeutic alternative for opioid induced constipation is the emergence of opioid/naloxone prolonged release combinations.For instance,naloxone when administered in a 1:2 ratio with oxycodone reverses the inhibitory effect of oxycodone on the gastrointestinal tract.The advantage of oxycodone/naloxone prolonged release(OXN) is that while its anti-nociceptive efficacy is equivalent to that of oxycodone prolonged release(OXC),it significantly decreases the 'Bowel Function Index' thereby ameliorating symptoms of opioid induced constipation to a large extent.Schutter et al in a recent study have reported a decrease in the bowel function index from 38.2 to 15.1.Similarly,L wenstein et al in another recent study have reported that following a month of therapy,complete spontaneous bowel movements per week is increased from one in OXC therapy to three in OXN therapy. | Shailendra Kapoor | 2012 | World Journal of Gastroenterology2012，18，29： | 4 |
| 10 | Bile duct injury repair --earlier is not better显示文摘胆汁管损害是胆囊炎的普通复杂并发症。预定胆汁管损害修理仍然保持争论。在法国进行的最近的评论在 133 个病人在迟了的修理以后与 14% 复杂并发症和 8%failure 相比在 194 个病人在立即的修理以后报导了 39% 复杂并发症和 64% 失败。在丹麦在五个 hepatopancreaticobiliary 中心进行的 139 个连续早修理的国家评论在 102 个月的中部的后续报导了 4% 死亡, 36% 病态,和 42 苛评(30%) ,并且仅仅 64 个病人(46%) 表明了平静短期、长期的结果。有与胆汁漏缝和败血在场的胆汁管损害的大多数病人;因此,早修理没被推荐。因为他们把尖锐胆汁管损害变换成控制的外部胆汁的管,胆汁和内视镜的 stenting 的经皮的排水是胆汁漏缝的治疗的支柱。一旦外部胆汁的管关门了,随后的良性的胆汁的苛评应该被一位胆汁的外科医生在 46 个星期的延期以后修理。 | Vinay K. Kapoor | 2015 | Frontiers of Medicine2015，9，4： | 4 |
| 11 | Intensive care unit complications and outcomes of adult patients with hemophagocytic lymphohistiocytosis: A retrospective study of 16 cases显示文摘AIM To study the management, complications and outcomes of adult patients admitted with hemophagocytic lymphohistiocytosis(HLH) in the intensive care unit(ICU).METHODS We performed a retrospective observational study of adult patients with the diagnosis of 'HLH' admitted to the two academic medical ICUs of Baylor College of Medicine between 01/01/2013 to 06/30/2017. HLH was diagnosed using the HLH-2004 criteria proposed by the Histiocyte Society.RESULTS Sixteen adult cases of HLH were admitted to the medical ICUs over 4 years.Median age of presentation was 49 years and 10(63%) were males. Median Sequential Organ Failure Assessment(SOFA) score at the time of ICU admission was 10. Median ICU length of stay(LOS) was 11.5 d and median hospital LOS was 29 d. Septic shock and acute respiratory failure accounted for majority of diagnoses necessitating ICU admission. Septic shock was the most common ICU complication seen in(88%) patients, followed by acute kidney injury(81%) and acute respiratory failure requiring mechanical ventilation(75%). Nine patients(56%) developed disseminated intravascular coagulation and eight(50%) had acute liver failure. 10 episodes of clinically significant bleeding were observed.Multi system organ failure was the most common cause of death seen in 12(75%)patients. The 30 d mortality was 37%(6 cases) and 90 d mortality was 81%(13 cases). There was no difference in mortality based on age(above or less than 50 years), SOFA score on ICU admission(more than or less than 10),immunosuppression, time to diagnose HLH or direct ICU admission versus floor transfer.CONCLUSION HLH is a devastating disease associated with poor outcomes in ICU. Intensivists need to have a high degree of clinical suspicion for HLH in patients with septic shock/multi system organ failure and progressive bi/pancytopenia who are not responding to standard management in ICU. | Sumit Kapoor Christopher K Morgan Muhammad Asim Siddique Kalpalatha K Guntupalli | 2018 | World Journal of Critical Care Medicine2018，7，6： | 3 |
| 12 | Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves显示文摘Objective:To discuss phytopharmacological potential and anti-asthmatic activity of Ficus religiosa(F.religiosa)(L.).Methods:Fresh leaves of F.religiosa were obtained from Vastrapur Lake,Ahmedabad,and dried to obtain powder.Histamine and acetylcholine were used to guinea pigs to establish bronchospasm model.In in vivo study,the aqueous extract of F.religiosa leaves (AEFR) at doses of 150 and 300 mg/ kg was administrated to guinea pigs,and the broncho-protective activity of AEFR was compared with aminophylline at 25 mg/kg.While in in vitro study,and 10 g/mL,20 g/mL,30 g/mL of AEFRL was administrated to guinea pigs,respectively, and mast cell stabilizing activity of AEFR was compared with ketotifen at 10 g/mL.Results: In the in-vivo model,pre-treatment with aminophylline(25 mg/kg,ip.) could significantly delay the onset of histamine induced pre-convulsive dyspnea,compared with vehicle control. Administration of AEFRL(150 and 300 mg/kg,ip.) also produced significant effect on latency to develop histamine & acetylcholine induced pre-convulsive dyspnea.In the mast cell stabilizing model,AEFRL at 10,20 and 30μg/mL could significantly increase the number of intact cells. Conclusions:It can be concluded that AEFRL is effective on histamine & acetylcholine induced bronchospasm in guinea pigs.In addition,AEFRL can potentiate the number of intact cells in the mast cell stabilizing model._____________________________________________________ | Megha Kapoor Nidhi Jasani Niyati Acharya Sanjeev Acharya Vimal Kumar | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 3 |
| 13 | Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology显示文摘Nigella sativa (N. sativa) decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa. N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride. | Shailendra Kapoor | 2009 | World Journal of Gastroenterology2009，15，17： | 3 |
| 14 | Graphene–aluminum nanocomposites显示文摘 | Stephen F. Bartolucci Joseph Paras Mohammad A. Rafiee Javad Rafiee Sabrina Lee Deepak Kapoor Nikhil Koratkar | 2011 | Materials Science & Engineering A2011，，27： | 2 |
| 15 | Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN显示文摘 | Zvi G. Fridlender Jing Sun Samuel Kim Veena Kapoor Guanjun Cheng Leona Ling G. Scott Worthen Steven M. Albelda | 2009 | Cancer Cell2009，，： | 2 |
| 16 | Performance characteristics of retrograde single-balloon endoscopy: A single center experience显示文摘AIM: To evaluate the technical success, diagnostic yield(DY) and therapeutic potential of retrograde single balloon enteroscopy(rS BE). METHODS: A retrospective review of 136 rS BE procedures performed at a tertiary academic referral center from January 2006 and September 2013 was completed. Patient characteristics including age, gender and inpatient status were collected. The indication for the procedure was categorized into one of three groups: Obscure gastrointestinal bleeding(GIB), evaluation for Crohn's disease and abnormal imaging. Procedural characteristics including insertion depth(ID), procedure time, concordance with pre-procedural imaging and complications were also recorded. Lastly, DY, defined as the percentage of cases producing either a definitive diagnosis or findings that could explain clinical symptoms and therapeutic yield(TY), defined as the percentage of cases in which a definitive intervention was performed, were determined. Mucosal tattooing and biopsy alone were not included in the TY. RESULTS: A total of 136 rS BE procedures were identified. Mean patient age was 57.5(± 16.2) years, 67(49.2%) were male, and 110(80.9%) procedures were performed on an outpatient basis. Indications for rS BE included GIB in 55(40.4%), evaluation of inflammatory bowel disease(IBD) in 29(21.3%), and imaging suggestive of pathology other than GIB or IBD in 43(31.6%). Nine(6.6%) rS BEs were performed for other indications. Mean ID was 68.3(± 39.3) cm proximal to the ileocecal valve and mean time to completion was 41.7(± 15.5) min. Overall, 73(53.7%) cases were diagnostic and 25(18.4%) cases were therapeutic in which interventions(argon plasma coagulation, stricture dilatation, polypectomy, etc.) were performed. Pre-procedural imaging was performed in 88(64.7%) patients. Endoscopic concordance of positive imaging findings was seen in 31(35.2%) cases. Follow up data was available in 93(68.4%) patients; 2(2.2%) reported post-procedural abdominal pain within 30 d following rS BE. There were no other reported complications. CONCLUSION: rS BE exhibits an acceptable diagnostic and TY, rendering it a safe and effective procedure for the evaluation and treatment of small bowel diseases. | Kaci E Christian Karan Kapoor Eric M Goldberg | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，15： | 2 |
| 17 | Aggressive Approach to Staghorn Calculi—Safety and Efficacy of Multiple Tracts Percutaneous Nephrolithotomy显示文摘 | Manish Singla Aneesh Srivastava Rakesh Kapoor Nitin Gupta Mohd S. Ansari Deepak Dubey Anant Kumar | 2008 | Urology2008，，6： | 2 |
| 18 | Comparative study of endoscopy vs.transjugular intrahepatic portosystemic shunt in the management of gastric variceal bleeding显示文摘Background and Aim:Gastric varices are associated with high mortality.There have been conflicting reports on whether endoscopic treatment with cyanoacrylate or the placement of a transjugular intrahepatic portosystemic shunt(TIPS)is more effective in the treatment of gastric varices.We compared the outcomes of patients treated with cyanoacrylate glue or TIPS for the management of acute gastric variceal bleeding.Methods:The study was designed as a retrospective cohort analysis of patients undergoing either TIPS or endoscopic treatment with cyanoacrylate for acute gastric variceal bleeding at our institution from 2001 to 2011.Primary compared to studied between the two treatment modalities were the short-term treatment outcomes,including re-bleeding within 30 days,length of hospital stay and in-hospital mortality.Kaplan-Meier survival analysis was performed to assess factors associated with in-hospital mortality.Results:A total of 169 patients were included in the analysis.The TIPS arm contained 140 patients and the cyanoacrylate arm contained 29 patients.There was no evidence to suggest any significant differences in demographics or disease severity.There were no differences between the TIPS arm and the cyanoacrylate armtwo groups in treatment outcomes including re-bleeding within 30 days(17.4%vs.17.2%;P=0.98),median length of stay in the hospital(4.5 days vs.6.0 days;P紏0.35)or in-hospital mortality(9.0%vs.11.1%;P=0.74).In-hospital mortality was evaluated for 149 patients and lower albumin(P=0.015),higher MELD score(P<0.001),higher CTP score(P=0.005)and bleeding(P=0.008)were all significantly associated with in-hospital death.Conclusion:These findings suggest that both treatments are equally effective.Cyanoacrylate offers a safe,effective alternative to TIPS for gastric varices,and physician may choose the best therapy for each patient,factoring in the availability of TIPS or cyanoacrylate,the individual patient’s presentation,and cost. | Gursimran Singh Kochhar Udayakumar Navaneethan Jason Hartman Jose Mari Parungao Rocio Lopez Ranjan Gupta Baljendra Kapoor Paresh Mehta Madhu Sanaka | 2015 | Gastroenterology Report2015，3，1： | 2 |
| 19 | Displaced intra-articular fractures of distal radius: a comparative evaluation of results following closed reduction, external fixation and open reduction with internal fixation显示文摘 | Harish Kapoor Ashoo Agarwal B.K Dhaon | 2000 | Injury2000，，2： | 2 |
| 20 | The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid Profiles in Hypogonadal Men显示文摘 | Chris J. Malkin Peter J. Pugh Richard D. Jones Dheeraj Kapoor Kevin S. Channer T Hugh Jones | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，7： | 2 |
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