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| 1 | Transjugular portosystemic stent shunt in treatment of liver diseases显示文摘INTRODUCTIONMore than 10 years ago ,an interventional technique for the creation of an intrahepatic decompressive shunt between a branch of the portal vein and a main hepatic vein using expandable metallic stents has been intriduced for the treatmint of portal hypertension[1,2],This transjugular portosystemic intrahepatic stent shunt (TIPS) functions as a side to side shunt ,similarly to surgical shunts . | Michael Schepke Tilman Sauerbruch | 2001 | World Journal of Gastroenterology2001，7，2： | 6 |
| 2 | C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma显示文摘AIM: To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort. METHODS: We retrospectively analyzed 98 patients with perihilar cholangiocarcinoma. Twenty-three patients (23.5%) underwent tumor resection. Patients with non- resectable tumors underwent either transpapillary or percutaneous transhepatic biliary drainage. Additionally, 32 patients (32.7%) received photodynamic therapy (PDT) and 18 patients (18.4%) systemic chemotherapy. Predefined variables at the time of diagnosis and characteristics considering the mode of treatment were entered into a Cox’s proportional hazards model. Included in the analysis were age, tumor stage following the modified Bismuth-Corlette classification, bilirubin, prothrombin time (PT), C-reactive protein (CRP), carbohydrate antigen 19-9 (CA19-9), history of weight loss, surgical resection, chemotherapy and PDT. RESULTS: The Kaplan-Meier estimate of overall median survival was 10.5 (95%CI: 8.4-12.6) mo. In the univariate analysis, low Bismuth stage, low CRP and surgical resection correlated significantly with better survival. In the multivariate analysis, only CRP (P = 0.005) and surgical resection (P = 0.029) were found to be independently predictive of survival in the cohort. Receiver operating characteristic (ROC) analysis identified a CRP level of 11.75 mg/L as the value associated with the highest sensitivity and specificity predicting a survival > 5 mo. Applying Kaplan-Meier analysis, patients with a CRP < 12 mg/L at the time of diagnosis had a signifi cantly longer median survival than patients with higher values (16.2 vs 7.6 mo; P = 0.009).CONCLUSION: This retrospective analysis identif ied CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity. | Thomas Gerhardt Sabine Milz Michael Schepke Georg Feldmann Martin Wolff Tilman Sauerbruch Franz Ludwig Dumoulin | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 3 | Fulminant sepsis after liver biopsy:A long forgotten complication?显示文摘We report on a 74-year-old patient with recurrent cholangitis and a large juxtapapillary duodenal diverticulum. Despite drainage of the common bile duct by an endoscopically placed stent, the elevated liver enzymes normalized only partially. To rule out other possible causes of liver injury, a percutaneous liver biopsy was done. After the liver biopsy the patient developed fulminant septic shock and died within 24 h. We discuss the possible causes of the septic shock following percutaneous liver biopsy in our patient and give a concise overview of the literature. | Corinna Claudi Martin Henschel Jürgen Vogel Michael Schepke Erwin Biecker | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 4 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C<!-- Doctopic: VH -->显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 5 | Does therapy of oesophageal varices influences the progression of varices?显示文摘 | Erwin Biecker Leonie Classen Tilman Sauerbruch Michael Schepke | 2009 | European Journal of Gastroenterology & Hepatology2009，，7： | 1 |
| 6 | Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: Evidence for a receptor-specific mechanism显示文摘 | Michael Schepke J?rg Heller Sebastian Paschke Julia Thomas Martin Wolff Markus Neef Max Malago Gerhard J. Molderings Ulrich Spengler Tilman Sauerbruch | 2001 | Hepatology2001，，5： | 1 |
| 7 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 8 | Novel Endocuff-assisted Colonoscopy Significantly Increases the Polyp Detection Rate: A Randomized Controlled Trial显示文摘 | Erwin Biecker Martin Floer Achim Heinecke Philipp Str?bel Rita B?hme Michael Schepke Tobias Meister | 2015 | Journal of Clinical Gastroenterology2015，，5： | 1 |
| 9 | Comparison of MELD, Child-Pugh, and Emory model for the prediction of survival in patients undergoing transjugular intrahepatic portosystemic shunting显示文摘 | Michael Schepke Felix Roth Rolf Fimmers Karl-August Brensing Thomas Sudhop Hans H Schild Tilman Sauerbruch | 2003 | The American Journal of Gastroenterology2003，，5： | 1 |
| 10 | Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: Evidence for a receptor-specific mechanism显示文摘 | Michael Schepke J?rg Heller Sebastian Paschke Julia Thomas Martin Wolff Markus Neef Max Malago Gerhard J. Molderings Ulrich Spengler Tilman Sauerbruch | 2001 | Hepatology2001，，5： | 1 |
| 11 | Altered adrenergic responsiveness of endothelium-denuded hepatic arteries and portal veins in patients with cirrhosis显示文摘 | J?rg Heller * Michael Schepke * Nina Gehnen * Gerhard J. Molderings ? Andreas Müller § Jochen Erhard ∥ Ulrich Spengler * Tilman Sauerbruch * | 1999 | Gastroenterology1999，，2： | 1 |
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