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您的检索式：作者名="Michael Theil"
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| 1 | Pharmacokinetics and toxicology of therapeutic proteins:Advances and challenges显示文摘Significant progress has been made in understanding pharmacokinetics (PK),pharmacodynamics (PD),as well as toxicity profiles of therapeutic proteins in animals and humans,which have been in commercial development for more than three decades.However,in the PK arena,many fundamental questions remain to be resolved.Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans,and from in vitro assays to in vivo readouts,which would ultimately lead to a higher success rate in drug development.In toxicology,it is known,in general,what studies are needed to safely develop therapeutic proteins,and what studies do not provide relevant information.One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity.In this review,we will highlight the emerging science and technology,as well as the challenges around the pharmacokinetic-and safety-related issues in drug development of mAbs and other therapeutic proteins. | Yulia Vugmeyster Frank-Peter Theil Leslie A Khawli Michael W Leach | 2012 | World Journal of Biological Chemistry2012，3，4： | 3 |
| 2 | Technology puah, legislation pull? E- government in the European Union显示文摘 | Gerhard Strejcek Michael Theil | 2002 | Decision Support Systems2002，，34： | 1 |
| 3 | 量子密码术:现在你看到了……显示文摘量子物理学家一般不会从像米德奈特上校——这个心怀叵测的电视观看者曾在1986年控制HBO(付费电视网)卫星长达四分半钟——这样的人身上获取动力。但是这一惊人之举有助于解释。 | Michael Hastings Stefan Theil 陈晓 | 2004 | 当代外语研究2004，，10： | 0 |
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