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| 1 | Novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets显示文摘Schizophrenia is a severe psychiatric disorder characterized by emotional,behavioral and cognitive disturbances, and the treatment of schizophrenia is oftencomplicated by noncompliance and pharmacoresistance. The search for thepathophysiological mechanisms underlying schizophrenia has resulted in theproposal of several hypotheses to explain the impacts of environmental, genetic,neurodevelopmental, immune and inflammatory factors on disease onset andprogression. This review discusses the newest insights into the pathophysiologyof and risk factors for schizophrenia and notes novel approaches in antipsychotictreatment and potential diagnostic and theranostic biomarkers. The currenthypotheses focusing on neuromediators (dopamine, glutamate, and serotonin),neuroinflammation, the cannabinoid hypothesis, the gut-brain axis model, andoxidative stress are summarized. Key genetic features, including small nucleotidepolymorphisms, copy number variations, microdeletions, mutations andepigenetic changes, are highlighted. Current pharmacotherapy of schizophreniarelies mostly on dopaminergic and serotonergic antagonists/partial agonists, butnew findings in the pathophysiology of schizophrenia have allowed theexpansion of novel approaches in pharmacotherapy and the establishment ofmore reliable biomarkers. Substances with promising results in preclinical andclinical studies include lumateperone, pimavanserin, xanomeline, roluperidone,agonists of trace amine-associated receptor 1, inhibitors of glycine transporters,AMPA allosteric modulators, mGLUR2-3 agonists, D-amino acid oxidase inhibitorsand cannabidiol. The use of anti-inflammatory agents as an add-on therapy ismentioned. | MatejĽupták Danica Michaličková Zdeněk Fišar Eva Kitzlerová Jana Hroudová | 2021 | World Journal of Psychiatry2021，11，7： | 3 |
| 2 | Effect of glycemic control on markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus:A review显示文摘Cardiovascular disease is the predominant cause of death in type 2 diabetes mellitus(T2DM).Evidence suggests a strong association between duration and degree of hyperglycemia and vascular disease.However,large trials failed to show cardiovascular benefit after intensive glycemic control,especially in patients with longer diabetes duration.Atherosclerosis is a chronic and progressive disease,with a long asymptomatic phase.Subclinical atherosclerosis,which is impaired in T2DM,includes impaired vasodilation,increased coronary artery calcification(CAC),carotid intima media thickness,arterial stiffness,and reduced arterial elasticity.Each of these alterations is represented by a marker of subclinical atherosclerosis,offering a cost-effective alternative compared to classic cardiac imaging.Their additional use on top of traditional risk assessment strengthens the predictive risk for developing coronary artery disease(CAD).We,herein,review the existing literature on the effect of glycemic control on each of these markers separately.Effective glycemic control,especially in earlier stages of the disease,attenuates progression of structural markers like intima-media thickness and CAC.Functional markers are improved after use of newer antidiabetic agents,such as incretin-based treatments or sodium-glucose cotransporter-2 inhibitors,especially in T2DM patients with shorter disease duration.Larger prospective trials are needed to enhance causal inferences of glycemic control on clinical endpoints of CAD. | Sofia Antoniou Katerina K K Naka Marios Papadakis Aris Bechlioulis Agathocles Tsatsoulis Lampros K Michalis Stelios Tigas | 2021 | World Journal of Diabetes2021，12，11： | 2 |
| 3 | An automated method for lumen and media-adventitia border detection in a sequence of IVUS frames 显示文摘 | Plissiti M E Fotiadics D I Michalis L K | 2004 | IEEE Transactions on Information Technology in Biomedicine2004，8，2： | 1 |
| 4 | Hydrodynamics of magnetic drug targeting显示文摘 | Voltairas P A Fotiades D I Michalis L K | 2002 | Journal of Biomechanics2002，35，6： | 1 |
| 5 | Incorporated evaporative condenser 显示文摘 | Michalis G V Andronikos E F Georgios T K | 2007 | Applied Thermal Eng2007，27，56： | 1 |
| 6 | An automated method for lumen and media-adventitia border detection in a sequence of IVUS frames 显示文摘 | Plissiti M E Fotiadis D I Michalis L K | 2004 | IEEE Transactions on Information Technology in Biomedicine2004，8，2： | 1 |
| 7 | Exercise-mediated adaptations in vascular function and structure:Beneficial effects in coronary artery disease显示文摘Exercise exerts direct effects on the vasculature via the impact of hemodynamic forces on the endothelium,thereby leading to functional and structural adaptations that lower cardiovascular risk.The patterns of blood flow and endothelial shear stress during exercise lead to atheroprotective hemodynamic stimuli on the endothelium and contribute to adaptations in vascular function and structure.The structural adaptations observed in arterial lumen dimensions after prolonged exercise supplant the need for acute functional vasodilatation in case of an increase in endothelial shear stress due to repeated exercise bouts.In contrast,wall thickness is affected by rather systemic factors,such as transmural pressure modulated during exercise by generalized changes in blood pressure.Several mechanisms have been proposed to explain the exercise-induced benefits in patients with coronary artery disease(CAD).They include decreased progression of coronary plaques in CAD,recruitment of collaterals,enhanced blood rheological properties,improvement of vascular smooth muscle cell and endothelial function,and coronary blood flow.This review describes how exercise via alterations in hemodynamic factors influences vascular function and structure which contributes to cardiovascular risk reduction,and highlights which mechanisms are involved in the positive effects of exercise on CAD. | Xenofon M Sakellariou Michail I Papafaklis Eleni M Domouzoglou Christos S Katsouras Lampros K Michalis Katerina K Naka | 2021 | World Journal of Cardiology2021，13，9： | 1 |
| 8 | Rarefaction effects on gas viscosity in the Knudsen transition regime显示文摘 | VASILIS K MICHALIS A N KALARAKIS E D | 2010 | Microfluid Nanofluid2010，9，45： | 1 |
| 9 | Application of membrane techniques in a water softening process显示文摘 | Michali B Stanislaw K Klaudia W | 2002 | Desalination2002，145，1： | 1 |
| 10 | Rarefaction effects on gas viscosity in the Knudsen transition regime 显示文摘 | Michalis Y K Kalarakis A N Skouras E D | 2010 | Microflu-idics and nanofluidics2010，9，4： | 1 |
| 11 | Relationships between nitrogen, dry matter accumulation and glucosinolates in Eruca sativa Mill显示文摘 | Michalis O Chara P Dimitra K | 2012 | Plant and Soil2012，1，： | 1 |
| 12 | Incorporated evaporative condenser显示文摘 | Michalis G V Andronikos E F Georgios T K | 2007 | Applied Thermal Eng2007，27，56： | 1 |
| 13 | Application of membrane techniques in a water softening process显示文摘 | Michali B Stanislaw K Klaudia W | 2002 | Desalination2002，145，13： | 1 |
| 14 | Infertility and thyroid disorders显示文摘 | Krinos M Nicos S Michalis K | 2006 | Curr Opin Obstet Gynecol2006，18，： | 1 |
| 15 | Mass spectrometricmapping of the enzymes involved in the phenol degradation of an indigenous soil pseudomonad 显示文摘 | Irene T Michalis A Michael K | 2004 | Bioehim Biophys Acta2004，1700，1： | 1 |
| 16 | An automated method for lumen and media-adventitia border detection in a sequence of IVUS frames显示文摘 | Plissiti M E Fotiadics D I Michalis L K | 2004 | IEEE Transactions on Information Technology in Biomedicne2004，8，2： | 1 |
| 17 | Occurrence and fate of heavy metals in the wastewater treatment process显示文摘 | MICHALIS K KATSOYIANNIS A SAMARA C | 2003 | Chemosphere2003，53，： | 1 |
| 18 | Hydrodynamics of magnetic drug targeting显示文摘 | Voltairas P A Fotiadis D I Michalis L K | | 0，，： | 1 |
| 19 | Fractional Flow Reserve: An Indispensable Diagnostic Tool in the Cardiac Cathetcrisation Laboratory显示文摘 | Michalis H Aaron P George K | 2010 | Hellenic J Cardiol2010，51，： | 1 |
| 20 | Evolution of new ap- pendage types by gradual changes in Hox gene expression-the case of crustacean maxillipeds显示文摘 | Michalis A Anastaslos P Zacharias K | 2010 | Palaeodiversity2010，3，： | 1 |
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