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| 1 | Long-term follow-up of children and adolescents with primary sclerosing cholangitis and autoimmune sclerosing cholangitis显示文摘BACKGROUND: Sclerosing cholangitis(SC) is a chronic cholestatic hepatobiliary disease with uncertain long-term prognosis in pediatric patients. This study aimed to evaluate longterm results in children with SC according to the types of SC.METHODS: We retrospectively followed up 25 children with SC over a period of 4-17 years(median 12). The diagnosis of SC was based on biochemical, histological and cholangiographic findings. Patients fulfilling diagnostic criteria for probable or definite autoimmune hepatitis at the time of diagnosis were defined as having autoimmune sclerosing cholangitis(ASC); other patients were included in a group of primary sclerosing cholangitis(PSC). The incidence of the following complications was studied: obstructive cholangitis, portal hypertension, advanced liver disease and death associated with the primary disease.RESULTS: Fourteen(56%) patients had PSC and 11(44%) had ASC. Patients with ASC were significantly younger at the time of diagnosis(12.3 vs 15.4 years, P=0.032) and had higher Ig G levels(22.7 vs 17.2 g/L, P=0.003). The mentioned complications occurred in 4(16%) patients with SC, exclusively in the PSC group: one patient died from colorectal cancer, one patient underwent liver transplantation and two patients, in whom severe bile duct stenosis was present at diagnosis, were endoscopically treated for acute cholangitis. Furthermore, twoother children with ASC and 2 children with PSC had elevated aminotransferase levels. The 10-year overall survival was 95.8% in all patients, 100% in patients without complicated liver disease, and 75.0% in patients with complications.CONCLUSION: In children, ASC is a frequent type of SC, whose prognosis may be better than that in patients with PSC. | Vratislav Smolka Eva Karaskova Oksana Tkachyk Kvetoslava Aiglova Jiri Ehrmann Kamila Michalkova Michal Konecny Jana Volejnikova | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，4： | 2 |
| 2 | Effect of mixing device and temperature on phase structure of neat and compatibilized polypropylene-polystyrene blends 显示文摘 | Fortelny I Michalkova D | 1998 | Plast Rub Compos Proce Appl1998，27，： | 1 |
| 3 | Evaluating the potential of three Fe- and Mn- (nano)oxides for the stabilization of Cd, Cu and Pb in contaminated soils显示文摘 | Michalkova Z Komarek M Sillerova H | 2014 | Journal of Environmental Management2014，146，： | 1 |
| 4 | Theoretical study of intercalation of dickite and kaolinite with small organic molecules显示文摘 | Michalkova A Tunega D Nagy L T | 2002 | Theochem2002，，581： | 1 |
| 5 | Effect of the Mixing Conditions on the Phase Structure of PP/PS Blends 显示文摘 | FORTELNY I MICHALKOVA D MIKESOVA J | 1996 | J Appl Polym Sci1996，59，： | 1 |
| 6 | Effect of Compatibilizer admixture, mixing conditions, and temperature on the development of the phase structure in polypropylene/polystyrene blends 显示文摘 | FORTELNY I MICHALKOVA D | 1997 | Polym Networks Blends1997，，3： | 1 |
| 7 | Theoretical study of intercalation of dickite and kaolinite显示文摘 | Michalkova A Tunega D Nagy L T | 2001 | Clays and Clay Miner2001，85，： | 1 |
| 8 | Immobilized glucose oxidase on different supports for biotransformation removal of glucose fromoligosaccharide mixtures显示文摘 | Mislovicova D Michalkova E Vikartovska A | 2007 | Process Biochemistry2007，42，： | 1 |
| 9 | The characters of kaolinite activated显示文摘 | Michalkova A Fripiat J J | 1990 | Clays and Clay Miner1990，43，： | 1 |
| 10 | Immobilized glucose oxidase on different supports for biotransformation removal of glucose from oligosaccharide mixtures显示文摘 | Mislovicova D Michalkova E Vikartovska A | 2007 | Process Biochem2007，42，： | 1 |
| 11 | Theoretical study of intercal ation of dickite and kaolinite 显示文摘 | Michalkova A Tunega D Nagy L T | 2001 | Clays and Clay Miner2001，85，： | 1 |
| 12 | The characters of kaolinite activated 显示文摘 | Michalkova A Fripiat J J | 1990 | Clays and Clay Miner1990，43，： | 1 |
| 13 | Characteristics of wood-plastic composites reinforced with organo-nanoclays显示文摘 | Ruijun Gu Bohuslav V Kokta D Michalkova | | 0，，24： | 1 |
| 14 | Pro- cessing and properties of alumina - carbon nano fibre ceramic com- posites using standard ceramic technology显示文摘 | Gurdial Blugan Monika Michalkova Miroslav Hnatko | 2011 | Ceramics Internation- al2011，37，8： | 1 |
| 15 | Characteristics of wood-plastic compmites reinforced with organo-nanoclays显示文摘 | GU R J BOHUSLAV V K MICHALKOVA D | | 0，，24： | 1 |
| 16 | Adsorption of 2,4-Dinitrotoluene on Dickite: The Role of H-Bonding显示文摘 | A. Michalkova J. J. Szymczak J. Leszczynski | 2005 | Structural Chemistry2005，，3： | 1 |
| 17 | Effect of the mixing conditions on the phase structure of PP/PS blends显示文摘 | FORTELNY I MICHALKOVA D MIKESOVA J | 1996 | J Appl Polym Sci1996，59，： | 1 |
| 18 | Immobi-lized glucose oxidase on different supports for biotransformation removal of glucose from oligosaccharide mixtures显示文摘 | Mislovicava D Michalkova E Vikartovska A | 2007 | Process Biochemistry2007，42，： | 1 |
| 19 | Immobilized glucose oxidase on different suppolts for biotransformation removal of glucose from oligosaccharide mixtures显示文摘 | MISLOVICOVA D MICHALKOVA E VIKARTOVSKA A | 2007 | Process Biochemistry2007，42，： | 1 |
| 20 | Compatibilization of polyethylene/poly(propylene)/polystyrene blends 显示文摘 | Ivan Fortelnv Zdenek Kruliv Danuve Michalkova | 1999 | Die Angewandte Makromolekulare Chemie1999，270，1： | 1 |
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