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| 1 | Irritable bowel syndrome: A concise review of current treatment concepts显示文摘Irritable bowel syndrome(IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology and treatment of IBS has given clinicians more options than ever to contend with this disorder. The purpose of our paper is to review older, 'classic' treatments for IBS as well as newer agents and 'alternative' therapies. We discuss the evidence base of these drugs and provide context to help develop appropriate treatment plans for IBS patients. | Geoffrey C Wall Ginelle A Bryant Michelle M Bottenberg Erik D Maki rew R Miesner | 2014 | World Journal of Gastroenterology2014，20，27： | 5 |
| 2 | Transient elastography: a new noninvasive method for assessment of hepatic fibrosis显示文摘 | Laurent Sandrin Bertrand Fourquet Jean-Michel Hasquenoph Sylvain Yon Céline Fournier Frédéric Mal Christos Christidis Marianne Ziol Bruno Poulet Farad Kazemi Michel Beaugrand Robert Palau | 2003 | Ultrasound in Medicine & Biology2003，，12： | 3 |
| 3 | Polyp detection rates using magnification with narrow band imaging and white light显示文摘AIM: To compare the yield of adenomas between narrow band imaging and white light when using high definition/magnification. METHODS: This prospective, non-randomized comparative study was performed at the endoscopy unit of veteran affairs medical center in Phoenix, Arizona. Consecutive patients undergoing first average risk colorectal cancer screening colonoscopy were selected. Two experienced gastroenterologists performed all the procedures that were blinded to each other's findings. Demographic details were recorded. Data are presented as mean ± SEM. Proportional data were compared using the χ2 test and means were compared using the Student's t test. Tandem colonoscopy was performed in a sequential and segmental fashion using one of 3 strategies: white light followed by narrow band imaging [Group A: white light(WL) → narrow band imaging(NBI)]; narrow band imaging followed by white light(Group B: NBI → WL) and, white light followed by white light(Group C: WL → WL). Detection rate of missed polyps and adenomas were evaluated in all three groups. RESULTS: Three hundred patients were studied(100 in each Group). Although the total time for the colonoscopy was similar in the 3 groups(23.8 ± 0.7, 22.2 ± 0.5 and 24.1 ± 0.7 min for Groups A, B and C, respectively), it reached statistical significance between Groups B and C(P < 0.05). The cecal intubation time in Groups B and C was longer than for Group A(6.5 ± 0.4 min and 6.5 ± 0.4 min vs 4.9 ± 0.3 min; P < 0.05). The withdrawal time for Groups A and C was longer than Group B(18.9 ± 0.7 min and 17.6 ± 0.6min vs 15.7 ± 0.4 min; P < 0.05). Overall miss rate for polyps and adenomas detected in three groups during the second look was 18% and 17%, respectively(P = NS). Detection rate for polyps and adenomas after first look with white light was similar irrespective of the light used during the second look(WL → WL: 13.7% for polyps, 12.6% for adenomas; WL → NBI: 14.2% for polyps, 11.3% for adenomas). Miss rate of polyps and adenomas however was significantly higher when NBI was used first(29.3% and 30.3%, respectively; P < 0.05). Most missed adenomas were ≤ 5 mm in size. There was only one advanced neoplasia(defined by size only) missed during the first look. CONCLUSION: Our data suggest that the tandem nature of the procedure rather than the optical techniques was associated with the detection of additional polyps' and adenomas. | Nooman Gilani Sally Stipho James D Panetta Sorin Petre Michele A Young Francisco C Ramirez | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 2 |
| 4 | A comparison of two-dimensional electrophoresis data with phenotypical traits in Arabi dopsis leads to the identification of a mutant (cril) that accumu lates cytokinins 显示文摘 | Veronique S Marianne D Michel C | 1997 | Planta1997，202，： | 1 |
| 5 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 6 | Levels of VEGF but not VEGF165b are Increased in the Vitreous of Patients With Retinal Vein Occlusion显示文摘 | Ehlken C Rennel ES Michels D Grundel B Pielen A Junker B etal | | 0，，： | 1 |
| 7 | Purification and characterization of prophenoloxidase from the haemolymph of Locusta migratoria 显示文摘 | Anas C Bernard D Michel B | 1996 | Arch Insect Biochem1996，32，： | 1 |
| 8 | High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinoma显示文摘 | Ying C Thomas D Michelle D | 2009 | Clin Cancer Res2009，15，2： | 1 |
| 9 | Diversification posture and top management team characteristics 显示文摘 | Michel J G Hambrick D C | 1992 | Academy of Management Journal1992，35，： | 1 |
| 10 | Amino acid odorants stimulate mi- crovillar sensory neurons显示文摘 | Lip'schitz D L Michel W C | 2002 | Chem Senses2002，27，3： | 1 |
| 11 | Measurement of local phase hold-ups in a two- and three-phase bubble column显示文摘 | Dziallas H Michele V Hempel D C | 2000 | Chemical Engineering and Technology2000，23，10： | 1 |
| 12 | Diversification posture and top management team characteristics 显示文摘 | Michel J G Hambfick D C | 1992 | Academy of Management Journal1992，35，1： | 1 |
| 13 | Diversification posture and top management team characteristics显示文摘 | Michel J G Hambrick D C | 1992 | Academy of Management Journal1992，35，1： | 1 |
| 14 | Truncated hilbert transform and image reconstructionfrom limited tomographic data显示文摘 | Michel D Frederic N Rolf C | 2006 | Inverse Problems2006，22，3： | 1 |
| 15 | The low temperature oxidation of DME and mutual sensitization of the oxidation of DME and nitric oxide: experimental and detailed kinetic modeling显示文摘 | Philippe D Jocelyn I Michel C | 2001 | Combustion Science and Technology2001，165，： | 1 |
| 16 | Recent approaches into the genetic basis of inbreeding depression in plants显示文摘 | DAVID E C MICHELE R D | 2003 | Phil Trans R Soc Lond B2003，358，1434： | 1 |
| 17 | Matrix metalloproteinase (MMP)-2,MMP-7,and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferalive process in the liver during chronic hepatitis C显示文摘 | LICHTINGHAGEN R MICHELS D HABERKORN C I | | J Hepatol0，，： | 1 |
| 18 | A Comparative Analysis of Current Credit Risk Models显示文摘 | Michel C Galai D Mark R | 2000 | Journal of Banking and Finance2000，，1： | 1 |
| 19 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 20 | The discovery of Saccharopolyspora spinosa and a new class of insect control products显示文摘 | Thompson G D Michel K H Yao R C | 1997 | Down to Earth1997，52，1： | 1 |
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