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| 1 | miRNA studies in in vitro and in vivo activated hepatic stellate cells显示文摘AIM: To understand which and how different miRNAs are implicated in the process of hepatic stellate cell (HSC) activation. METHODS: We used microarrays to examine the differential expression of miRNAs during in vitro activation of primary HSCs (pHSCs). The transcriptome changes upon stable transfection of rno-miR-146a into an HSC cell line were studied using cDNA microarrays. Selected differentially regulated miRNAs were investigated by quantitative real-time polymerase chain reaction during in vivo HSC activation. The effect of miRNA mimics and inhibitor on the in vitro activation of pHSCs was also evaluated.RESULTS: We found that 16 miRNAs were upregulated and 26 were downregulated significantly in 10-d in vitro activated pHSCs in comparison to quiescent pHSCs. Overexpression of rno-miR-146a was characterized by marked upregulation of tissue inhibitor of metalloproteinase-3, which is implicated in the regulation of tumor necrosis factor-α activity. Differences in the regulation of selected miRNAs were observed comparing in vitro and in vivo HSC activation. Treatment with miR-26a and 29a mimics, and miR-214 inhibitor during in vitro activation of pHSCs induced significant downregulation of collagen type Ⅰ transcription. CONCLUSION: Our results emphasize the different regulation of miRNAs in in vitro and in vivo activated pHSCs. We also showed that miR-26a, 29a and 214 are involved in the regulation of collagen type I mRNA. | Gunter Maubach Michelle Chin Chia Lim Henry Yang | 2011 | World Journal of Gastroenterology2011，17，22： | 12 |
| 2 | 晶粒取向对镍基超合金Inconel690离子渗氮速率的影响显示文摘对镍基超合金Inconel6 90进行了离子渗氮处理。利用扫描电镜 (SEM)、X射线衍射 (XRD)及电子背散射衍射 (EBSD)等手段对渗氮层进行了表征。结果表明 :Inconel 6 90经低温离子渗氮处理生成氮在奥氏体中的过饱和固溶相 (γN 相 ) ;取向不同的晶粒γN 层厚度不同 ;γN 层生长速度在θ<1 0 0 >(<10 0>晶向和渗层生长方向的最小夹角 )值较小的晶粒内比在θ<1 0 0 >值较大的晶粒内快 ,并且γN 层厚度与θ<1 0 0 >大致呈线性关系。 | 何欢 董闯 THIERRY Czerwiec HENRI Michel | 2004 | 材料热处理学报2004，25，6： | 9 |
| 3 | Hepatitis B surface antigen quantification: Why and how to use it in 2011 – A core group report显示文摘 | Henry Lik-Yuen Chan Alex Thompson Michelle Martinot-Peignoux Teerha Piratvisuth Markus Cornberg Maurizia Rossana Brunetto Hans L. Tillmann Jia-Horng Kao Ji-Dong Jia Heiner Wedemeyer Stephen Locarnini Harry L.A. Janssen Patrick Marcellin | 2011 | Journal of Hepatology2011，，5： | 5 |
| 4 | The role of radiotherapy in localised and locally advanced prostate cancer显示文摘For a patient suffering from non-metastatic prostate cancer,the individualized recommendation of radiotherapy has to be the fruit of a multidisciplinary approach in the context of a Tumor Board,to be explained carefully to the patient to obtain his informed consent.External beam radiotherapy is now delivered by intensity modulated radiotherapy,considered as the gold standard.From a radiotherapy perspective,low-risk localized prostate cancer is treated by image guided intensity modulated radiotherapy,or brachytherapy if patients meet the required eligibility criteria.Intermediate-risk patients may benefit from intensity modulated radiotherapy combined with 4e6 months of androgen deprivation therapy;intensity modulated radiotherapy alone or combined with brachytherapy can be offered to patients unsuitable for androgen deprivation therapy due to co-morbidities or unwilling to accept it to preserve their sexual health.High-risk prostate cancer,i.e.high-risk localized and locally advanced prostate cancer,requires intensity modulated radiotherapy with long-term(≥2 years)androgen deprivation therapy with luteinizing hormone releasing hormone agonists.Post-operative irradiation,either immediate or early deferred,is proposed to patients classified as pT3pN0,based on surgical margins,prostate-specific antigen values and quality of life.Whatever the techniques and their degree of sophistication,quality assurance plays a major role in the management of radiotherapy,requiring the involvement of physicians,physicists,dosimetrists,radiation technologists and computer scientists.The patients must be informed about the potential morbidity of radiotherapy and androgen deprivation therapy and followed regularly during and after treatment for tertiary prevention and evaluation.A close cooperation is needed with general practitioners and specialists to prevent and mitigate side effects and maintain quality of life. | Michel Bolla Ann Henry Malcom Mason Thomas Wiegel | 2019 | Asian Journal of Urology2019，6，2： | 5 |
| 5 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 6 | Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases显示文摘 | Michel Gonzalez John Henri Robert Nermin Halkic Gilles Mentha Arnaud Roth Thomas Perneger Hans Beat Ris Pascal Gervaz | 2012 | World Journal of Surgery2012，，2： | 2 |
| 7 | Adhesive Postoperative Small Bowel Obstruction: Incidence and Risk Factors of Recurrence After Surgical Treatment: A Multicenter Prospective Study显示文摘 | Jean-Jacques Duron Nathalie Jourdan-Da Silva Sophie Tezenas du Montcel Anne Berger Fabrice Muscari Henri Hennet Michel Veyrieres Jean Marie Hay | 2006 | Annals of Surgery2006，，5： | 2 |
| 8 | Carotid Plaque Pathology: Thrombosis, Ulceration, and Stroke Pathogenesis显示文摘 | Mark Fisher Annlia Paganini-Hill Aldana Martin Michele Cosgrove James F. Toole Henry J.M. Barnett John Norris | 2005 | Stroke2005，，2： | 2 |
| 9 | Guidelines for the prevention of intravascular catheter-related infections显示文摘 | Naomi P. O’Grady Mary Alexander Lillian A. Burns E. Patchen Dellinger Jeffrey Garland Stephen O. Heard Pamela A. Lipsett Henry Masur Leonard A. Mermel Michele L. Pearson Issam I. Raad Adrienne G. Randolph Mark E. Rupp Sanjay Saint | 2011 | AJIC: American Journal of Infection Control2011，，4： | 2 |
| 10 | Management of Complications Associated with Partially Covered Biliary Metal Stents显示文摘 | Henry Ho Anshu Mahajan Sonia Gosain Animesh Jain Andrew Brock Michele E. Rehan Kristi Ellen Vanessa M. Shami Michel Kahaleh | 2010 | Digestive Diseases and Sciences2010，，2： | 2 |
| 11 | Meshed capillary vessels found on narrow-band imaging without optical magnification effectively identifies colorectal neoplasia: a North American validation of the Japanese experience显示文摘 | Zachary H. Henry Paul Yeaton Vanessa M. Shami Michel Kahaleh James T. Patrie Dawn G. Cox David A. Peura Fabian Emura Andrew Y. Wang | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 12 | An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma显示文摘 | George P. Kim Michelle R. Mahoney Daniel Szydlo Tony S. K. Mok Robert Marshke Kyle Holen Joel Picus Michael Boyer Henry C. Pitot Joseph Rubin Philip A. Philip Anna Nowak John J. Wright Charles Erlichman | 2012 | Investigational New Drugs2012，，1： | 2 |
| 13 | Stability of travelling fronts in a model for flame propagation part I: Linear analysis显示文摘 | Henri Berestycki Bernard Larrouturou Jean -Michel Roquejoffre | 1992 | Archive for Rational Mechanics and Analysis1992，，2： | 1 |
| 14 | Reflections on using a UIMS for complex applications显示文摘 | Kasik David J Lund Michelle A Ramsey Henry W | 1989 | IEEE Software1989，6，1： | 1 |
| 15 | Material Phenomenology and Language (or, Pathos and Language)显示文摘 | Michel Henry | 1999 | Continental Philosophy Review1999，，3： | 1 |
| 16 | Hepatitis B surface antigen quantification: Why and how to use it in 2011 – A core group report显示文摘 | Henry Lik-Yuen Chan Alex Thompson Michelle Martinot-Peignoux Teerha Piratvisuth Markus Cornberg Maurizia Rossana Brunetto Hans L. Tillmann Jia-Horng Kao Ji-Dong Jia Heiner Wedemeyer Stephen Locarnini Harry L.A. Janssen Patrick Marcellin | 2011 | Journal of Hepatology2011，，5： | 1 |
| 17 | Localized squamous-cell cancer of the esophagus: retrospective analysis of three treatment schedules显示文摘 | Corinne Delcambre Jacques Henry Jacob Didier Pottier Marc Gignoux Jean Michel Ollivier Brigitte Vie Alain Roussel Philippe Segol | 2001 | Radiotherapy and Oncology2001，，2： | 1 |
| 18 | Formation of natural gas hydrates in marine sediments,thermodynamic calculations of stability conditions in porous sediments显示文摘 | Pierre Henry Michel Thomas Ben Clennell | 1999 | Journal of Geophysical Research1999，104，23： | 1 |
| 19 | Guidelines for the prevention of intravascular catheter-related infections显示文摘 | Naomi P. O’Grady Mary Alexander Lillian A. Burns E. Patchen Dellinger Jeffrey Garland Stephen O. Heard Pamela A. Lipsett Henry Masur Leonard A. Mermel Michele L. Pearson Issam I. Raad Adrienne G. Randolph Mark E. Rupp Sanjay Saint | 2011 | AJIC: American Journal of Infection Control2011，，4： | 1 |
| 20 | Nouvelle introduction a la didactique du francais langue etrangere显示文摘 | BOYER Henri BUTZBACH Michele PENDANX Michele | 1990 | CLE International1990，，： | 1 |
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