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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Arterial Stiffness Is Regulated by Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor During Changes in Blood Flow in Humans显示文摘 | Jeremy Bellien Julie Favre Michele Iacob Ji Gao Christian Thuillez Vincent Richard Robinson Joannidès | 2010 | Hypertension2010，，3： | 2 |
| 3 | Oligomerization of endothelial nitric oxide synthase: evidence for a dominant negative effect of truncation mutants显示文摘 | Robinson LJ Michel T | 1995 | J Biol Chem1995，270，27： | 1 |
| 4 | Cystic Fibrosis Foundation Evidence-Based Guidelines for Management of Infants with Cystic Fibrosis显示文摘 | Drucy Borowitz Karen A. Robinson Margaret Rosenfeld Stephanie D. Davis Kathryn A. Sabadosa Stephanie L. Spear Suzanne H. Michel Richard B. Parad Terry B. White Philip M. Farrell Bruce C. Marshall Frank J. Accurso | 2009 | The Journal of Pediatrics2009，，： | 1 |
| 5 | Mutagenesis of palmitoylation site in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subeellar targeting显示文摘 | Robinson LJ Michel T | 1995 | Proc Natl Acad Sci USA1995，92，11： | 1 |
| 6 | Cystic Fibrosis Foundation Evidence-Based Guidelines for Management of Infants with Cystic Fibrosis显示文摘 | Drucy Borowitz Karen A. Robinson Margaret Rosenfeld Stephanie D. Davis Kathryn A. Sabadosa Stephanie L. Spear Suzanne H. Michel Richard B. Parad Terry B. White Philip M. Farrell Bruce C. Marshall Frank J. Accurso | 2009 | The Journal of Pediatrics2009，，6： | 1 |
| 7 | Agonist-modulated palmiloylation of endothelial nitic oride synthase显示文摘 | Robinson Ij Busconi L Michel T | 1995 | J Biol chem1995，270，3： | 1 |
| 8 | Classification of different sustainable flood retention basin types显示文摘Using a revised version of a previously published expert classification system,a database of potential Sustainable Flood Retention Basins has been developed for Scotland.The research shows that the majority of small and former (often old) drinking water reservoirs are kept full and their spillways are continuously in operation.Utilising some of the available capacity to contribute to flood control could significantly reduce the costs of complying with the European Union Flood Directive.Furthermore,the application of a previously developed classification model for Baden in Germany for the Scottish data set showed a lower diversity for basins in Scotland due to less developed infrastructure.The classification system appears to be robust and has the potential,with minor modifications,to be applied across Europe.The principle value of this approach is a clear and unambiguous categorisation,based on standard variables,which can help to promote communication and understanding between stakeholders. | Michelle Robinson Miklas Scholz Nicolas Bastien Jennifer Carfrae | 2010 | Journal of Environmental Sciences2010，22，6： | 1 |
| 9 | Agonist-modulated palmitoylation of endothelial nitric oxide synthase 显示文摘 | Robinson LJ Busconi L Michel T | 1995 | J Biol Chem1995，270，3： | 1 |
| 10 | Agonist-modulated palmitoylation of endothelial nitric oxide synthase显示文摘 | ROBINSON L J BUSCONI L MICHEL T | 1995 | J Biol Chem1995，270，3： | 1 |
| 11 | The Lunar Reconnaissance Orbiter Miniature Radio Frequency (Mini-RF) Technology Demonstration显示文摘 | Stewart Nozette Paul Spudis Ben Bussey Robert Jensen Keith Raney Helene Winters Christopher L. Lichtenberg William Marinelli Jason Crusan Michele Gates Mark Robinson | 2010 | Space Science Reviews (-)2010，，1： | 1 |
| 12 | Calcium-Activated potassium channels and NO regulate human peripheral conduit artery mechanics显示文摘 | Robinson J Michele I | 2005 | Hypertension2005，46，： | 1 |
| 13 | 恐龙公主显示文摘从前有这样一本书,书名很古怪。书的主人是恐龙公主,她叫莉莉黛。莉莉黛,人人爱,因为她的魅力无人能赛。 | Michelle Robinson Fred Blunt 刘怡雯(译注) 肖芬(审校) | 2018 | 英语广场2018，0，7： | 0 |
| 14 | Comparison of pediatric ventriculoperitoneal shunt infections arising in antibiotic-impregnated and standard catheters:a multicenter observational study显示文摘Antibiotic-impregnated ventricular shunt catheters(AIVSCs)with 0.15%clindamycin and 0.054%rifampin are commonly used to prevent ventriculo-peritoneal(VP)shunt infections.Initially approved by the United States Food and Drug Administration in 2003(https://www.integralife.com/file/general/1561404015.pdf),they have antimicrobial activity documented for minimum 31 days(https://www.accessdata.fda.gov/cdrh_docs/pdf11/K110560.pdf).These antibiotics were chosen as they cover the majority of Staphylococcus aureus and may provide some activity against coagulase negative staphylococci.1 These normal skin flora account for the majority of VP shunt infections.In the largest randomized controlled trial(RCT)to date,AIVSCs significantly reduced the risk of infection compared with standard shunts(cause-specific hazard ratio(HR)0.38).2 This effect was mainly due to a reduction in staphylococcal infections;the number of gram-negative infections was similar in both groups.Observational studies3–5 and a meta-analysis6 in children support the findings of this RCT.The objective of this study was to examine the spectrum of pathogens,time to infection,and outcomes with AIVSCs vs standard shunts. | Joan Robinson Archana Balamohan Michelle Barton Marie-Astrid Lefebvre Ahmed Almadani Dolores Freire Alastair McAlpine Jocelyn Srigley Patrick Passarelli John Bradley Dele Davies Gwenn Skar Isabelle Viel-Theriault Sarah Khan Rupeena Purewal Nicole LeSaux Jennifer Bowes Michael Hawkes 无 | 2023 | World Journal of Pediatric Surgery2023，6，3： | 0 |
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