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	题名	作者	年代	出处	被引量
1	Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism显示文摘	Yuping Chen Steve S. Choi Gregory A. Michelotti Isaac S. Chan Marzena Swiderska-Syn Gamze F. Karaca Guanhua Xie Cynthia A. Moylan Francesca Garibaldi Richard Premont Hagir B. Suliman Claude A. Piantadosi Anna Mae Diehl	2012	Gastroenterology2012，，5：	2
2	炎症对原发性肝细胞肿瘤的生长和免疫微环境的影响(英文)显示文摘原发性肝细胞癌(HCC)的起始和发展与肝脏慢性疾病密切相关.与正常肝脏相比,肝脏慢性疾病引起微环境的剧烈变化,尤其影响免疫细胞的功能.为了研究肝脏疾病对于肿瘤生长的影响以及与肿瘤微环境的互相作用,我们采用两种标准化方法诱导肝脏纤维化,并将肿瘤原位移植到发炎并纤维化的肝脏上模拟人类HCC患者的肝脏状态.与健康对照组相比,肝脏的纤维化显著促进肿瘤生长.在两种诱导纤维化的模型中,浸润肿瘤的免疫细胞也发生显著变化:自然杀伤细胞减少,而免疫抑制的骨髓细胞CD11b+Gr1hi显著增加.此外,存在模型特异的区别:在胆管结扎模型的肿瘤中,CD11b+骨髓细胞和CD4+CD25+T细胞数量增加,但在四氯甲烷模型中没有变化.纤维化能改变移植的肿瘤细胞中的细胞因子产生,可能对免疫功能产生深远的影响.综上所述,本研究揭示了肝脏纤维化诱导结合肿瘤原位移植能显著改变肿瘤微环境以及肿瘤生长动态,提示在动物模型中模拟HCC时需要考虑慢性肝脏疾病对肝脏的重要影响.	Geoffrey J. Markowitz Gregory A. Michelotti Anna Mae Diehl Xiao-Fan Wang	2015	Science Bulletin2015，60，8：	2
3	alphal-adrenergic receptors in the lower urinary tract and vascular bed:potential role for the alphald subtype in filling symptoms and effects of ageing on vascular expression显示文摘	Schwinn D A Michelotti G A	2000	BJU Int2000，852，：	1
4	al-Adrenergic receptor regulation: basic science and clinical implications 显示文摘	Michelotti GA Price DT Schwinn DA	2000	Pharmacol Ther2000，88，2：	1
5	Alphal adrenergic receptors in the lower urinary tract and vascular bed:potential role for the alphald subtype in filling symptoms and effects of ageing on vascular expression显示文摘	Schwinn DA Michelotti GA	2000	BJU Iht2000，85，2：	1
6	A child's sleeping habit as a cause of nursing caries显示文摘	Schwariz SS Rosivack RG Michelotti P	1993	J Dent Child1993，60，：	1
7	Multicenter randomized controlled clinical trial to evaluate cardioprotection of dexrazoxane versus no cardioprotection in women receiving epirubicin chemotherapy for advanced breast cancer 显示文摘	Venturini M Michelotti A Del Mastro L	1996	J Clin Oncol1996，14，：	1
8	Form homogenepus to supported metallocene catalysts 显示文摘	Ciardelli F Altomare A Michelotti M	1998	Catalysis Today1998，41，13：	1
9	Masticatory thickness, endurance and exercise induced pain in subjects with dif- ferent vertical craniofacial morphology显示文摘	Farella M Bakke M Michelotti A	2003	Eur J Oral Sci2003，111，3：	1
10	NAFLD, NASH and liver canc- er显示文摘	Michelotti GA Machado MV Diem AM	2013	Nat Rev Gastroenterol Hepatol2013，10，11：	1
11	Hedgehog sig- naling in the liver显示文摘	OMENE-FII A CHOI S MICHELOTTI G	2011	J Hepatol2011，54，2：	1
12	From homogeneous to supported metaUocene catalysts显示文摘	Ciardelli F Altomare A Michelotti M		0，，1：	1
13	al-adrenergic receptors in the lower urinary tract and vascular bed: Potential role for the a(1d) subtype in filling symptoms and effects of ageing on vascular expression显示文摘	SCHWINN D A MICHELOTTI G A	2000	BJUlnternational2000，85，2：	1
14	Smoothened is a master regulator of adult liver repair 显示文摘	Michelotti GA Xie G Swiderska M	2013	J Clin Invest2013，123，6：	1
15	The curve of Spee&craniofacial morphology:a multiple regressionanalysis显示文摘	Farella M Michelotti A Van Eijden	2002	Eur J Oral Sci2002，110，4：	1
16	A child's sleeping habit as a cause of nursing caries显示文摘	Schwartz SS Rosivack RG Michelotti P	1993	ASDC J Dent1993，163，1：	1
17	Mandibular rest position and electrical activity of the masticatory muscles显示文摘	Michelotti A Farella M Vollaro S	1997	J Prosthet Dent1997，78，1：	1
18	The curve of Spee and eraniofacial morphology: a multiple regression analysis 显示文摘	Farella M Michelotti A van Eijden TM	2002	EurJ OralSci2002，110，4：	1
19	Surgical approach to the stylohyoid process in Eagle's syndrome 显示文摘	Buono U Mangone GM Michelotti A	2005	J Oral Maxillofac Surg2005，63，5：	1
20	Form homogenepus to suppor- ted metallocene catalysts 显示文摘	Ciardelli F Altomare A Michelotti M	1998	Catalysis Today1998，41，13：	1

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