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您的检索式：作者名="Michiko ho"
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| 1 | Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice显示文摘The inhibitory effects of a formulated product from citrus peel extract,Gold Lotion(GL),on 12-O-tetradecanoylphorbol 13-acetate(TPA)-induced expression of inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)in mouse skin was reported in this study.It is found that in the TPA-induced skin inflammation model,the topical application of GL effectively inhibited the transcriptional activation of iNOS and its mRNA and protein in mouse skin.It is also discovered that GL significantly inhibited TPA-induced mouse skin inflammation by decreasing inflammatory gene parameters.Furthermore,GL dramatically inhibited 7,12-dimethylbenez[a]anthracene(DMBA)/TPA-induced skin tumor formation and reduced tumor incidence,tumor weight and tumor multiplicity of papillomas at 20 weeks.In essence,these in vivo data have revealed that GL is an effective anti-tumor agent that functions by down-regulating the protein levels of COX-2,ornithine decarboxylase(ODC),and vascular endothelial growth factor(VEGF)in mouse skin,suggesting that GL is a novel functional natural product capable of preventing inflammation-associated tumorigenesis.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Min-Hsiung Pan Shiming Li Ching-Shu Lai Yutaka Miyauchi Michiko Suzawa Chi-Tang Ho | 2012 | Food Science and Human Wellness2012，1，1： | 7 |
| 2 | Inhibitory effects of natural carotenoids, orcarotene, β-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats显示文摘 | Tomio Narisawa Yoko Fukaura Makiko Hasebe Michiko ho Rika Aizawa Michiaki Murakoshi Shingo Uemura Frederick Khachik Hoyoku Nishino | 1996 | Cancer Letters1996，107，1： | 1 |
| 3 | Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury(TBI)in rats显示文摘Traumatic brain injury(TBI)is closely related to neuro-inflammatory response and causes a complex pathological process and serious consequence.In this study,we explored whether the formatted citrus peel extract gold lotion(GL)could have a therapeutic effect on rats suffered TBI.TBI rat model was prepared by the electric Cortical Contusion Impactor(eCCI)device.Prevention against TBI by GL was assessed by the behavioral,organizational of rats and the molecular markers in the brain injury area.The results showed that GL could reduce nerve damage and neurological dysfunction.The mechanisms probably due to that GL could not only reduce the associated damage markers including GFAP,OX-42,TNF-α,COX-2,NF-κB and TLR4 but also promote the expression of VEGF which is responsible for protecting neuronal cells in the injury area.These findings revealed that GL could be a promising preparation for TBI prevention. | Guang Cheng Zhiwei Yue Liwen Wang Yutaka Miyauchi Michiko Suzawa Shiming Li Chi-Tang Ho Hui Zhao Naiyao Chen | 2020 | Food Science and Human Wellness2020，9，3： | 0 |
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