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| 1 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 2 | Biodegmdation of apolymeric dye in apulsed bed bioreaetor by immobilized Phanerochaele ehrysosporium 显示文摘 | MIELGO I MOREIRA M T FEIJOO G | 2002 | Water Research2002，36，： | 1 |
| 3 | A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms显示文摘 | Mielgo A van DM Bloem A | | 0，，： | 1 |
| 4 | The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8 显示文摘 | Wrasidlo W Mielgo A Tortes VA | 2008 | Proe Natl Acad Sci U S A2008，105，7： | 1 |
| 5 | Oxidative degradation of azo dyes by manganese peroxidase under optimized conditions显示文摘 | Mielgo I Lopez C Moreira M T | 2003 | Biotechnol Prog2003，19，： | 1 |
| 6 | Impact of tumour associated macrophages in pancreatic cancer显示文摘 | Mielgo A Schmid MC | 2013 | BMB Rep2013，46，3： | 1 |
| 7 | Identification of a critical tyrosine residue in caspase 8 that promotes cell migration显示文摘 | Barbero S Baril D Mielgo A | 2008 | J Biol Chem2008，283，13： | 1 |
| 8 | The marine lipopeptide Somocystinamide A triggers apoptosis via caspase 8 显示文摘 | Wrasidlo W Mielgo A Tones V A | 2008 | Appl Bi- ol Sei2008，10，： | 1 |
| 9 | Optimisati - on of the treatment of acute gout显示文摘 | Perez Ruiz F Mielgo FJ Gonzalez Herrero Beites A- M | 2000 | Bio Drugs2000，13，6： | 1 |
| 10 | Effect of surfactant and partial liquid ventilation treatment on gas exchange and lung mechanics in immature lambs: influence of gestational age 显示文摘 | Rey-Santano C Mielgo V Gastiasoro E | 2013 | PLoS One2013，8，2： | 1 |
| 11 | Impact of tumour associated macrophages in pancreatic cancer显示文摘 | Mielgo A Schmid MC | 2013 | BMB Rep2013，46，3： | 1 |
| 12 | Comparative effects of bronchoalveolar lavage with saline, surfactant, or perfluorocarbon in experimental meconium aspiration synd- rome显示文摘 | Rey-Santano C Mielgo V E Gastiasoro E | 2012 | Pediatr Crit Care Med2012，13，3： | 1 |
| 13 | Are quality and innovation management conflicting activities? 显示文摘 | Mielgo N L Peon J M M Vazquez-ordas C J | 2009 | Technovation2009，29，8： | 1 |
| 14 | Caspase - 8 association with the focal adhesion complex promotes tumor cell migration and metastasis显示文摘 | Barbero S Mielgo A Torres V | 2009 | Cancer Res2009，69，9： | 1 |
| 15 | Identification of a critical tyrosine residue in caspase 8 that promotes cell migration 显示文摘 | Barbero S Barild D Mielgo A | 2008 | J Biol Chem2008，283，13： | 1 |
| 16 | Brmasted acid assisted regio - and enantioselective direct o-nitroso aldol reaction catalysed by α,α-diphenylprolinol trimethylsilyl ether显示文摘 | Antonia Mielgo Irene Velilla Enrique Gomez- Bengoa | | 0，，25： | 1 |
| 17 | Oxidative degradation of azo dyes by manganese peroxidase under optimized conditions显示文摘 | Mielgo I Lopez C Moreira M T | 2003 | Biotechnol Prog2003，19，： | 1 |
| 18 | Bmnsted acid assisted regio - and enantioseleetive direct o-nitroso aldol reaction catalysed by a,a- diphenylprolinol trimethylsilyl ether显示文摘 | Irene Velilla Antonia Mielgo Enrique G mez-Bengoa Claudio Palomo | | 0，，： | 1 |
| 19 | A packed-bed fungal bioreactor for the continuous decolourisation of azo-dyes ( Orange Ⅱ) 显示文摘 | MIELGO I MOREIRA M T FEIJOO G | 2001 | J Biotechnol2001，89，23： | 1 |
| 20 | The marine lipopep-tide somocystinamide A triggers apoptosis via caspase 8 显示文摘 | Wrasidlo W Mielgo A Torres VA | 2008 | Proc Natl Acad Sci U S A2008，105，： | 1 |
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