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| 1 | Impact of the metabolic syndrome on the evolution of neurodegenerative diseases显示文摘Metabolic syndrome(MetS)might be defined as the simultaneous accumulation of s everal functional changes that frequently occur in adults over 60 years of age(Gomez et al.,2018).The diagnosis of MetS requires the presence of three or more factors such as high body mass,type-2 diabetes mellitus(T2DM),dyslipidemia,and arterial hypertension,which increase the risk of cardiovascular diseases as well as neurological complications,as stroke and dementia(Dyken and Lacoste,2018).Usually,these functional changes coincide and result in insensitivity for example hormones as leptin,adiponectin,and insulin(Dyken and Lacoste,2018). | Ana Paula de A.Boleti Jeeser Alves Almeida Ludovico Migliolo | 2021 | Neural Regeneration Research2021，16，4： | 4 |
| 2 | Identification and characterization of a bactericidal and proapoptotic peptide from cycas revoluta seeds with DNA binding properties显示文摘 | Mandal S M Migliolo L Das S | | 0，，： | 1 |
| 3 | Identification of anovel antimicrobial peptide from Brazilian coast coral Phyllogorgiadilatata显示文摘 | de Lima LA Migliolo L Barreiro e Castro C | 2013 | Protein Pept Lett2013，20，10： | 1 |
| 4 | Identification andcharacterization of a bactericidal and proapoptotic pep-tide from Cycas revoluta seeds with DNA binding proper-ties 显示文摘 | Mandal SM Migliolo L Das S | 2012 | J Cell Biochem2012，113，1： | 1 |
| 5 | Identification and charae terization of a bactericidal and proapoptotic peptide from Cyeas revoluta seeds with DNA binding properties显示文摘 | Mandal SM Migliolo L Das S | 2012 | J Cell Biochem2012，113，18： | 1 |
| 6 | Purification and characterization of a trypsin-papain inhibitor from Pithecelobium dumosum seeds and its in vitro effects towards digestive enzymes from insect pests显示文摘 | OLIVEIRA A S MIGLIOLO L AQUINO R O | 2007 | Plant Physiology and Biochemistry2007，45，1011： | 1 |
| 7 | Controlling resistant bacteria with a novel class of beta-lactamase inhibitor peptides:from rational de- sign to in vivo analyses显示文摘 | Mandal SM Migliolo L Silva ON | 2014 | Sci Rep2014，4，： | 1 |
| 8 | Iden- tification and characterization of a bacteri- cidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding proper- ties显示文摘 | Mandal SM Migliolo L Das S | 2012 | J Cell Biochem2012，113，1： | 1 |
| 9 | IMM- JPDA Versus MHT and Kalman Filter with NN Correla- tion: Performance Comparison 显示文摘 | de Feo M GRAZIANO A MIGLIOLO R | 1997 | IEE Proceedings Radar Sonar Navigation1997，144，2： | 1 |
| 10 | Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties显示文摘 | MANDAL SM MIGLIOLO L DAS S | 2012 | J Cell Biochem2012，113，1： | 1 |
| 11 | Cn-AMPI: a new promiscuous peptide with potential for microbial infections treatment 显示文摘 | Silva ON Porto WF Migliolo L | 2012 | Biopolymers2012，98，4： | 1 |
| 12 | 适度运动对自发性高血压大鼠心脏组织线粒体蛋白质组的影响显示文摘高血压是一种多因素疾病,是心血管病的一个重要的独立危险因素。运动训练是治疗高血压最重要的非药物治疗策略之一,然而,运动使心脏发生线粒体适应改变的机制仍然不清楚。 | Rocha LA Oliveira KS Migliolo L Franco OL 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 0 |
| 13 | Adipose tissue,systematic inflammation,and neurodegenerative diseases显示文摘Obesity is associated with several diseases,including mental health.Adipose tissue is distributed around the internal organs,acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the tissues.Excessive nutritional intake results in hypertrophy and proliferation of adipocytes,leading to local hypoxia in adipose tissue and changes in these adipokine releases.This leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory cytokines.The presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling,which can generate a neuroinflammatory process.In this review,we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive dysfunction.We also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain,particularly the hypothalamus and hippocampus,and that this is partially responsible for these negative cognitive outcomes.In addition,we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system. | Ana Paula de A.Boleti Pedro Henrique de O.Cardoso Breno Emanuel F.Frihling Patrícia Souza e Silva Luiz Filipe R.Nde Moraes Ludovico Migliolo | 2023 | Neural Regeneration Research2023，18，1： | 0 |
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