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| 1 | Hepatitis C virus-associated B cell non-Hodgkin's lymphoma显示文摘The hepatitis C virus(HCV) infected patients are prone to develop bone marrow or various tissue infiltrates with monoclonal B cells, monoclonal B lymphocytosis or different types of B cell non-Hodgkin's lymphoma(BCNHL), of which the most common are splenic marginal zone BCNHL, diffuse large BCNHL and follicular lymphoma. The association between chronic HCV infection and non Hodgkin's lymphoma has been observed especially in areas with high prevalence of this viral infection. Outside the limitations of some studies that have been conducted, there are also geographic, environmental, and genetic factors that contribute to the epidemiological differences. Various microenvironmental signals, such as cytokines, viral antigenic external stimulation of lymphocyte receptors by HCV antigens, and intercellular interactions contribute to B cell proliferation. HCV lymphotropism and chronic antigenic stimulation are involved in B-lymphocyte expansion, as mixted cryoglobulinemia or monoclonal gammopathy of undetermined significance, which can progress to BCNHL. HCV replication in B lymphocytes has oncogenic effect mediated by intracellular HCV proteins. It is also involved in an important induction of reactive oxygen species that can lead to permanent B lymphocyte damage, as DNA mutations, after binding to surface B-cell receptors. Posttransplant lymphoproliferative disorder could appear and it has a multiclonal potentiality that may develop into different types of lymphomas. The hematopoietic stem cell transplant made for lymphoma in HCV-infected patients can increase the risk of earlier progression to liver fibrosis and cirrhosis. HCV infected patients with indolent BCNHL who receive antiviral therapy can be potentially cured. Viral clearance was related to lymphoma response, fact that highlights the probable involvement of HCV in lymphomagenesis. Direct acting antiviral drugs could be a solution for the patients who did not tolerate or respond to interferon, as they seem to be safe and highly effective. The use of chemotherapy in combination with rituximab for the treatment of BCNHL in patients infected with HCV can produce liver dysfunction. The addition of immunotherapy with rituximab can increase the viral replication, and severe complications can occure especially in patients co-infected with hepatitis B virus or immune immunodeficiency virus, in those with hepatocarcinoma,cirrhosis, or liver cytolysis. But the final result of standard immunochemotherapy applied to diffuse large BCNHL patients with HCV infection is not notably worse than in those without this viral infection. The treatment of patients chronically infected with HCV and having BCNHL is complex and requires a multidisciplinary approach and the risk / benefit ratio of rituximab treatment must be evaluated especially in those with liver cytolysis. | Romeo-Gabriel Mihaila | 2016 | World Journal of Gastroenterology2016，22，27： | 4 |
| 2 | Perfusion characterization of liver metastases from endocrine tumors:Computed tomography perfusion显示文摘AIM:To assess prospectively parameters of computed tomography perfusion(CT p) for evaluation of vascularity of liver metastases from neuroendocrine tumors.METHODS:This study was approved by the hospital's institutional review board.All 18 patients provided informed consent.There were 30 liver metastases from neuroendocrine tumors.Patients were divided into three groups depending on the appearance of the liver metastases at the arterial phase of morphological CT(hyperdense,hypodense and necrotic).Sequential acquisition of the liver was performed before and for 2 min after intravenous injection of 0.5 mg/kg contrast medium,at 4 mL/s.Data were analyzed using deconvolution analysis to calculate blood flow(BF),blood volume(BV),mean transit time(MTT),hepatic arterial perfusion index(HAPI) and a bi-compartmental analysis was performed to obtain vascular permeability-surface area product(PS).Post-treatment analysis was performed by a radiologist and regions of interest were plotted on the metastases,normal liver,aorta and portal vein.RESULTS:At the arterial phase of the morphological CT scan,the aspects of liver metastases were hyperdense(n=21),hypodense(n=7),and necrotic(n=2).In cases of necrotic metastases,none of the CT p parameters were changed.Compared to normal liver,a significant difference in all CT p parameters was found in cases of hyperdense metastases,and only for HAPI and MTT in cases of hypodense metastases.No significant difference was found for MTT and HAPI between hypo-and hyperdense metastases.A significant decrease of PS,BV and BF was demonstrated in cases of patients with hypodense lesions PS(23±11.6 mL/100 g per minute) compared to patients with hyperdense lesions;PS(13.5±10.4 mL/100 g per minute),BF(93.7±75.4 vs 196.0±115.6mL/100 g per minute) and BV(9.7±5.9 vs 24.5 10.9 mL/100 g).CONCLUSION:CT p provides additional information compared to the morphological appearance of liver metastases. | Aurélie Guyennon Marius Mihaila John Palma Catherine Lombard-Bohas Jean-Alain Chayvialle Frank Pilleul | 2010 | World Journal of Radiology2010，2，11： | 2 |
| 3 | A dual outbreak of blood- stream infections with linezolid-resistant Staphylococcus epidermidis and Staphylococcus pettenkoferi in a liver Intensive Care Unit显示文摘 | Mihaila L Defrance G Levesque E | 2012 | Int J Antimicrob Agents2012，40，5： | 1 |
| 4 | Family involve- ment in dental health education Of school children 显示文摘 | Carausu EM Mihaila CB Indrei LL | 2002 | Rev Med Chir Soc Med Nat Iasi2002，107，2： | 1 |
| 5 | The crucial role of particle morphology in the magnetic properties of haematite显示文摘 | Sorescu M Brand R A Mihaila T D | 1999 | J Appl Phys1999，85，8： | 1 |
| 6 | Streptococcus sinensis: an emerging agent of infective endocarditis 显示文摘 | Faibis F Mihaila L Pema S | 2008 | J Med Microbiol2008，57，： | 1 |
| 7 | Hydrothermal synthesis and characterization of some polycrystalline-iron oxides显示文摘 | Diamandescu L Mihaila T D Popescu P N | 1999 | Ceramics International1999，25，5： | 1 |
| 8 | High chromosome instability and occasional R249S TP53 Mutation characterize hepatocellular carcinoma in Romania显示文摘 | Agnès Marchio Anna-Maria Tanase Traian Dumitrascu Mariana Mihaila Simona Dima Anne Dejean Irine Popescu Gabriela Oprisan Pascal Pineau | 2010 | Cancer Genetics and Cytogenetics2010，，1： | 1 |
| 9 | Querying the World Wide Web 显示文摘 | MENDELZON A MIHAILA G MILO T | 1997 | International Joumal on Digital Libraries1997，1，1： | 1 |
| 10 | Phys Rev Lett Evidence for the Color-Octet Mechanism from CERN LEP2 γγ→J/ψ+ X Data显示文摘 | KLASEN M KNIEHL B A MIHAILA L N | 2002 | Phys Rev Lett2002，89，3： | 1 |
| 11 | Imprssion Management and Self-Deception Positivity in the Identification of Depression with the MMPI-2显示文摘 | Emilian Mihaila | 2003 | Pacific Graduate School of Psychology2003，，： | 1 |
| 12 | SSD bufferpool extensions for database systems显示文摘 | Canim M Mihaila GA Bhattacharjee B | 2010 | Proceedings of the VLDB Endowment2010，3，2： | 1 |
| 13 | When experts agree: using non-affiliated experts to rank popular-topics显示文摘 | BHARAT K MIHAILA G A | 2002 | ACM Transactions on Information Systems (TOIS)2002，，： | 1 |
| 14 | An object placement advisor for DB2using solid state storage显示文摘 | Canim M Mihaila GA Bhattacharjee B | 2009 | Proceedings of the VLDB Endowment2009，2，2： | 1 |
| 15 | Family involvement in dental health education of school children 显示文摘 | Carausu EM Mihaila CB Indrei LL | 2002 | Rev Med Chir Soc Med Nat Iasi2002，107，2： | 1 |
| 16 | Liquid-vapor equilibrium of the system furfural-chloroform at atmospheric pressure显示文摘 | Ababi V Mihaila G Cruceanu M | 1965 | Stud Cercet Chim1965，13，9： | 1 |
| 17 | Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing显示文摘 | Tep S Mihaila R Freeman A | | 0，，： | 1 |
| 18 | Liquid-vapor equilibrium of the system furfural-chloroform at atmospheric pressure显示文摘 | Ababi V Mihaila G Cruceanu M | 1965 | Rev Roum Chim1965，10，： | 1 |
| 19 | Meningiomas:loss of hetewzygosity on chromosome 10 and marker-specific correlations with grade,recurrence,and survival显示文摘 | Mihaila D Jankowski M Gutierrez JA | 2003 | Clin Cancer Res2003，9，12： | 1 |
| 20 | Long term agricuhural experiments in eastern Europe 显示文摘 | Mihaila V Hera C | 1993 | Long-term Experiments in Agricuhural and Ecological Science1993，，2： | 1 |
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