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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Vitamin D3 supplementation of cull cows : Effects on longissimus and semitendinosus muscle tenderness 显示文摘 | N Rider Sell W B Mikel Y L Xiong | 2004 | J Anim Sci2004，82，225： | 1 |
| 3 | Vitamin D3 supplementation of cull cows:effects on longissi- mus and semitendinosus muscle tenderness 显示文摘 | RIDER S N MIKEL W B XIONG Y L | 2004 | Journal of Animal Science2004，82，1： | 1 |
| 4 | IGF-1 gene therapy to protect articular cartilage in a rat model of joint damage显示文摘 | I?igo Izal Carlos Alberto Acosta Purificación Ripalda Mikel Zaratiegui Juan Ruiz Francisco Forriol | 2008 | Archives of Orthopaedic and Trauma Surgery2008，，2： | 1 |
| 5 | Zosteriform cutaneous metastases from breast adenocarcinoma显示文摘 | Konstantinos B Mikel N Sofia D | 2005 | J Eur Acad Dermatol Venereol2005，19，5： | 1 |
| 6 | Vitamin D3 supplementation of cull cows:Effects on longissimus and semitendinosus muscle tenderness显示文摘 | Rider Sell N Mikel W B Xiong Y L | 2004 | J Anim Sci2004，82，1： | 1 |
| 7 | Vitamin D3 supplementation of cull cows: Effects on longissimus andsemitendinosus muscle tendenaess显示文摘 | Rider S N Mikel W B Xiong Y L | 2004 | J Anim Sci2004，82，： | 1 |
| 8 | Vitamin D3 supplementation of cull cows:Effects on longissimus and semitendinosus muscle tendemess显示文摘 | Rider Sell N Mikel W B Xiong Y L | 2004 | J Anim Sci2004，82，1： | 1 |
| 9 | Early tacrolimus exposure does not impact long-term outcomes after liver transplantation显示文摘BACKGROUND Tacrolimus trough levels(TTL)during the first weeks after liver transplantation(LT)have been related with long-term renal function and hepatocellular carcinoma recurrence.Nevertheless,the significance of trough levels of tacrolimus during the early post-transplant period for the long-term outcome is under debate AIM To evaluate the effect of TTL during the first month on the long-term outcomes after LT.METHODS One hundred fifty-five LT recipients treated de novo with once-daily tacrolimus were retrospectively studied.Patients with repeated LT or combined transplantation were excluded as well as those who presented renal dysfunction prior to transplantation and/or those who needed induction therapy.Patients were classified into 2 groups according to their mean TTL within the first month after transplantation:≤10(n=98)and>10 ng/mL(n=57).Multivariate analyses were performed to assess risk factors for patient mortality.RESULTS Mean levels within the first month post-transplant were 7.4±1.7 and 12.6±2.2 ng/mL in the≤10 and>10 groups,respectively.Donor age was higher in the high TTL group 62.9±16.8 years vs 45.7±17.5 years(P=0.002)whilst mycophenolate-mofetil was more frequently used in the low TTL group 32.7%vs 15.8%(P=0.02).Recipient features were generally similar across groups.After a median follow-up of 52.8 mo(range 2.8-81.1),no significant differences were observed in:Mean estimated glomerular filtration rate(P=0.69),hepatocellular carcinoma recurrence(P=0.44),de novo tumors(P=0.77),new-onset diabetes(P=0.13),or biopsy-proven acute rejection rate(12.2%and 8.8%,respectively;P=0.50).Eighteen patients died during the follow-up and were evenly distributed across groups(P=0.83).Five-year patient survival was 90.5%and 84.9%,respectively(P=0.44),while 5-year graft survival was 88.2%and 80.8%,respectively(P=0.42).Early TTL was not an independent factor for patient mortality in multivariate analyses.CONCLUSION Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients. | Mikel Gastaca Patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso JoséRamón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador Maria Senosiain Maria Jesus Suárez Andres Valdivieso | 2021 | World Journal of Hepatology2021，13，3： | 0 |
| 10 | GOECP/SEOR radiotherapy guidelines for thymic epithelial tumours显示文摘Thymic epithelial tumours(TET)are rare,heterogeneous neoplasms that range from resectable indolent tumours to aggressive thymic carcinomas with a strong tendency to metastasize.The pathological diagnosis is complex,in part due to the management of TETs is scant and mainly based on non-randomised studies and retrospective series.Consequently,the clinical management of TETs tends to be highly heterogenous,which makes it difficult to improve the evidence level.The role of technological advances in the field of radiotherapy and new systemic therapies in the treatment of TETs has received little attention to date.In the present clinical guidelines,developed by the GOECP/SEOR,we review recent developments in the diagnosis and classification of TETs.We also present a consensus-based therapeutic strategy for each disease stage that takes into consideration the best available evidence.These guidelines focus primarily on the role of radiotherapy,including recent advances,in the management of TETs.The main aim of this document is to promote the standardisation of clinical practice and lay the foundations for future studies to clarify the main unresolved questions related to the optimal management of TET. | Mikel Rico Sonia Flamarique Cristina Casares Tamara García Miriam López Maribel Martínez Javier Serrano Manuel Blanco Raúl Hernanz Lourdes de Ingunza-Barón Francisco JoséMarcos Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，4： | 0 |
| 11 | 生命早期室外空气污染暴露与婴幼儿呼吸系统健康、耳部感染和湿疹:INMA研究显示文摘[背景]产前和生命早期可能是空气污染对婴幼儿健康造成有害影响的重要窗口期。[目的]选择西班牙出生队列中2199名婴儿,研究他们在孕期和出生第1年空气污染暴露与年龄为12~18个月时的呼吸系统疾病、耳部感染和湿疹之间的关联。[方法]父母提供医生诊断的呼吸道感染(LRTI)、喘息、湿疹和耳部感染等信息。使用经时间调整的土地利用回归模型,估计个体二氧化氮(NO2)和苯的暴露情况。采用对数二项式回归模型和联合随机效应meta分析,评估4个研究地点空气污染暴露对健康结果的影响。[结果]在孕期,NO2均值每增加10μg/m3与LRT[I相对危险度(RR)=1.05,95%CI:0.98~1.12]和耳部感染(RR=1.18,95%CI:0.98~1.41)相关联。NO2每增加1个四分位距(IQR),LRTI的RR为1.08(95%CI:0.97~1.21),耳部感染的RR为1.31(95%CI:0.97~1.76)。与NO2相比,苯暴露均值每增加1个IQR,其与LRTI具有类似的关联性(RR=1.06,95%CI:0.94~1.19),与耳部感染的关联性稍弱(RR=1.17,95%CI:0.93~1.46)。母亲孕期大多数时间在家里的婴幼儿,其关联性稍强。由于出生第1年的空气污染暴露与产前暴露高度相关,所以无法分辨各个暴露时期的相对重要性。[结论]研究结果表明生命早期环境空气污染暴露可能增加婴幼儿上、下呼吸道感染的风险。 | Inmaculada Aguilera Marie Pedersen Raquel Garcia-Esteban Ferran Ballester Mikel Basterrechea Ana Esplugues Ana Fernández-Somoano Aitana Lertxundi Adonina Tardón Jordi Sunyer | 2013 | 环境与职业医学2013，30，6： | 0 |
| 12 | Suitability of open-field autorefractors as pupillometers and instrument design effects显示文摘AIM:To determine the agreement and repeatability of the pupil measurement obtained with VIP-200(Neuroptics),Power Ref II(Plusoptix),WAM-5500(Grand Seiko) and study the effects of instrument design on pupillometry.METHODS:Forty patients were measured twice in low,mid and high mesopic.Repeatability was analyzed with the within-subject standard deviation(Sw) and paired t-tests.Agreement was studied with Bland-Altman plots and repeated measures ANOVA.Instrument design analysis consisted on measuring pupil size with Power Ref II simulating monocular and binocular conditions as well as with proximity cues and without proximity cues.RESULTS:The mean difference(±standard deviation) between test-retest for low,mid and high mesopic conditions were,respectively:-0.09(±0.16),-0.05(±0.18) and-0.08(±0.23) mm for Neuroptics,-0.05(±0.17),-0.12(±0.23) and-0.17(±0.34) mm for WAM-5500,-0.04(±0.27),-0.13(±0.37) and-0.11(±0.28) mm for Power Ref II.Regarding agreement with Neuroptics,the mean difference for low,mid and high mesopic conditions were,respectively:-0.48(±0.35),-0.83(±0.52) and-0.38(±0.56) mm for WAM-5500,-0.28(±0.56),-0.70(±0.55) and-0.61(±0.54) mm for Power Ref II.The mean difference of binocular minus monocular pupil measurements was:-0.83(±0.87) mm;and with proximity cues minus without proximity cues was:-0.30(±0.77) mm.CONCLUSION:All the instruments show similar repeatability.In all illumination conditions,agreement of Neuroptics with WAM-5500 and Power Ref II is not good enough,which can be partially induced due to their open field design. | Carles Otero Mikel Aldaba Oriol Ferrer Andrea Gascón Juan C Ondategui-Parra Jaume Pujol | 2017 | International Journal of Ophthalmology(English edition)2017，10，4： | 0 |
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