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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Universal moral grammar: Theory, evidence and the future显示文摘 | MIKHAIL J | 2007 | Trends in Cognitive Sciences2007，，11： | 1 |
| 3 | Rapid differenti- ation of Staphylococcus aureus, Staphylococcus epidermidis and other coagulase-negative staphylococci and meticillin susceptibility testing directly from growth-positive blood cultures by multiplex re- al-time PCR 显示文摘 | Jukes L Mikhail J Bome-Mannathoko N | 2010 | J Med Microbiol2010，59，2： | 1 |
| 4 | A Survey of AntiTamper Technologies显示文摘 | Mikhail J Atallah Eric D Bryant Martin R Stytz | 2004 | CROSSTALK:The Journal of Defense Software Engineering2004，17，11： | 1 |
| 5 | Faster Image Template Matching in the Sum of Absolute Value of Differences Measure显示文摘 | Mikhail J Atallah | 2001 | IEEE Trans on Image Processing2001，10，4： | 1 |
| 6 | The trauma triad of death:hypothermia,acidosis,and coagulopathy显示文摘 | Mikhail J | 1999 | ACCN Clin Issues1999，10，1： | 1 |
| 7 | The trauma triad of death : hypothermia, aci- dosis,and coagulopathy 显示文摘 | Mikhail J | 1999 | AACN Clin Issues1999，10，1： | 1 |
| 8 | The trauma triad of death : hypothermia, acidosis, and coagulopathy 显示文摘 | Mikhail J | 1999 | ACCN Clin Issues1999，10，： | 1 |
| 9 | Self-incompatibility in the Brassicaceae 显示文摘 | Kachroo A Mikhail E and Nasrallah J B | 2002 | Plant Cell2002，14，： | 1 |
| 10 | Faster Image Template Matching in the Sum of the Absolute Value of Differences Measure显示文摘 | Mikhail J Atallah | 2001 | IEEE Trans on Image Processing2001，10，4： | 1 |
| 11 | High frequency of fetal cells within a primitive stem cell population in maternal blood 显示文摘 | Mikhail MA MHamdi H Welsh J | 2008 | Hum Reprod2008，23，4： | 1 |
| 12 | The trauma trial of death: hypothermia acidosis, and coagulopathy显示文摘 | | 1999 | ACCN Clin Issues1999，10，： | 1 |
| 13 | The trauma triad of death:hypothermia,acidosis,and coagulopathy显示文摘 | Mikhail J | | 0，，01： | 1 |
| 14 | Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression显示文摘 | Osman I Dai J Mikhail M | 2006 | Cancer2006，107，11： | 1 |
| 15 | Rigorous Mathematical Modeling of Airborne Pushbroom Imaging Systems 显示文摘 | CHANGNO LEE HENRY J THEISS JAMES S BETHEL EDWARD M MIKHAIL | 2000 | PE&RS2000，66，4： | 1 |
| 16 | Rapid detection of type A influenza viruses with monoclonal antibodies to the M protein (M1) by enzyme-linked immunosorbent assay and time-resolved fluoroimmunoassay显示文摘 | Bucher D J Mikhail A Popple S | 1991 | J Clin Microbio1991，11，： | 1 |
| 17 | The trauma triad of death: hypothermia, acidosis,and coagulopathy 显示文摘 | Mikhail J | 1999 | ACCN Clin Issues1999，10，1： | 1 |
| 18 | Terrain surface approximation and on-line quality assessment显示文摘 | BETHEL J S MIKHAIL E M | 1984 | International Archives of Photogrammetry and Remote Sensing1984，25，32： | 1 |
| 19 | Universal Moral Grammar:Theory,Evidence and the Future显示文摘 | Mikhail J | 2007 | Trends in Cognitive Sciences2007，11，4： | 1 |
| 20 | Use of array comparative genome hybridization in orofacial clefting显示文摘 | Gallego C J Grant J Mikhail F M | 2010 | J Craniofac Surg2010，21，5： | 1 |
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