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| 1 | Inflammatory bowel disease:Epidemiology,pathology and risk factors for hypercoagulability显示文摘Hypercoagulability observed in patients with inflammatory bowel diseases(IBD)may lead to thromboembolic events(TE),which affect the venous and arterial systems alike and are an important factor in patients’morbidity and mortality.The risk of TE in IBD patients has been demonstrated to be approximately threefold higher as compared to the general population.The pathogenesis of thrombosis in IBD patients is multifactorial and not fully explained.The most commonly listed factors include genetic and immune abnormalities,disequilibrium between procoagulant and anticoagulant factors,although recently,the role of endothelial damage as an IBD-triggering factor is underlined.Several studies report that the levels of some coagulation enzymes,including fibrinogen,factorsⅤ,Ⅶ,Ⅷ,active factorⅪ,tissue factor,prothrombin fragment 1+2and the thrombin-antithrombin complex,are altered in IBD patients.It has been demonstrated that there is a significant decrease of tissue plasminogen activator level,a marked increase of plasminogen activator inhibitor type 1 and thrombin-activable fibrinolysis inhibitor,a significantly lower level of antithrombinⅢand tissue factor pathway inhibitor.IBD patients have been also observed to produce an increased amount of various anticoagulant antibodies.Hyperhomocysteinemia,which is a potential risk factor for TE was also observed in some IBD patients.Further studies are necessary to assess the role of coagulation abnormalities in IBD etiology and to determine indications for thromboprophylactic treatment in patients at high risk of developing TE. | Danuta Owczarek Dorota Cibor Mikolaj K Glowacki Tomasz Rodacki Tomasz Mach | 2014 | World Journal of Gastroenterology2014，20，1： | 16 |
| 2 | 白鬼笔蘑菇菌丝体多糖:免疫调节和伤口愈合特性(英文)显示文摘白鬼笔蘑菇在亚洲和北欧是一种传统的民间医药。本文综述了我们人工培养白鬼笔菌丝体的研究成果,以及从白鬼笔菌丝体中分离出的多糖的生物活性数据。对白鬼笔新菌株菌丝体的培养形态特征和生理生化特性进行了研究。经过优化培养基的营养物构成和培养条件能够使菌体生物量提高1.3倍,多糖含量提高1.5~1.7倍。从该菌丝体中分离的多糖在体外和在体内(链脲佐菌素诱导的糖尿病大鼠)均具有免疫调节作用。与原始软膏相比,含有10%白鬼笔多糖的软膏,能促进实验大鼠的皮肤创面愈合,促进肉芽组织的上皮形成、收缩和生长。综上所述,白鬼笔菌丝体多糖有望成为开发功能性食品以及新型治疗和预防药物的原材料。 | BUKO Vyacheslav BAKUNOVICH Alexey ASTROWSKI Aliaksandr MOROZ Valentina PUCHKOVA Tatyana KASTSIANEVICH Aliaksandar TOMULEWICZ Mikolaj | 2019 | 现代食品科技2019，35，9： | 14 |
| 3 | Laser-induced white-light emission from graphene ceramics–opening a band gap in graphene显示文摘Recent theoretical and experimental studies have indicated the existence of a new stable phase of carbon with mixed sp^(2) and sp^(3) hybridized bonds—diaphite.Such a two-layered structure with sp^(2)/sp^(3) bonds may be observed after the photostimulation of highly oriented pyrolytic graphene with femtosecond laser pulses.This hidden multistability of graphene may be used to create a semiconducting phase immersed in the semimetallic continuum,resulting in bandgap opening.We demonstrate that bandgap opening and light emission from graphene is possible using continuous-wave laser beams with wavelengths from the visible(405 nm)to the near-infrared range(975 nm).We demonstrate that without the application of cooling,the effective temperature of the emitting sample remains lower than 900 K,which is far below the value predicted by the theory of black-body radiation.Moreover,light emission from a graphene sample may be observed at temperatures as low as 10 K. | Wieslaw Strek Bartlomiej Cichy Lukasz Radosinski Pawel Gluchowski Lukasz Marciniak Mikolaj Lukaszewicz Dariusz Hreniak | 2015 | Light(Science & Applications)2015，4，1： | 6 |
| 4 | Liver resections can be performed safely without Pringle maneuver: A prospective study显示文摘AIM To evaluate liver resections without Pringle maneuver, i.e., clamping of the portal triad. METHODS Between 9/2002 and 7/2013, 175 consecutive liver resections(n = 101 major anatomical and n = 74 large atypical > 5 cm) without Pringle maneuver were performed in 127 patients(143 surgeries). Accompanying, 37 wedge resections(specimens < 5 cm) and 43 radiofrequency ablations were performed. Preoperative volumetric calculation of the liver remnant preceeded all anatomical resections. The liver parenchyma was dissected by waterjet. The median central venous pressure was 4 mmH g(range: 5-14). Data was collected prospectively. RESULTS The median age of patients was 60 years(range: 16-85). Preoperative chemotherapy was used in 70 cases(49.0%). Liver cirrhosis was present in 6.3%, and liver steatosis of ≥ 10% in 28.0%. Blood loss was median 400 mL(range 50-5000 mL). Perioperative blood transfusions were given in 22/143 procedures(15%). The median weight of anatomically resected liver specimens was 525 g(range: 51-1850 g). One patient died postoperatively. Biliary leakages(n = 5) were treated conservatively. Temporary liver failure occurred in two patients.CONCLUSION Major liver resections without Pringle maneuver are feasible and safe. The avoidance of liver inflow clamping might reduce liver damage and failure, and shorten the hospital stay. | Christoph A Maurer Mikolaj Walensi Samuel A Kaser Beat M Künzli Rene Lotscher Anne Zuse | 2016 | World Journal of Hepatology2016，8，24： | 6 |
| 5 | 28个绿芦笋品种的适应性评价(英文)显示文摘[目的]本文旨在对波兰气候条件下的28个绿芦笋品种进行适应性评价,并选择出最适合在波兰种植的品种。[方法]2008年在马赛林试验站对第六年收获的28个品种的绿芦笋进行评价。收获期间,将收获的芦笋嫩茎,剪至22cm,分级,称重,同时对嫩茎外观、花青素变化、芦笋头紧实性、颜色及光滑度等性状进行评估。[结果‘]Gynlim’是产量最高的品种,其次为‘Hannibal’,‘Ravel’,‘Grolim’和‘Ramada’。‘Gloria’是最差的品种,其它最差的品种以次为‘Tsuki-kho3’、‘PurplePassion’、‘Jacq.Ma2014’、‘Sartaguda’、和‘Jacq.Ma2004’。‘Gynlim’、‘Hannibal’、‘Ravel’、‘Ramada’、‘Ariane’是前期产量最高的前5个品种。前期产量最差的品种为‘PLA-2132’,随后是‘Ramos’、‘Tsuki-kho3’和‘PurplePassion’。‘Ariane’、‘Cipress’、‘Grolim’、‘Gynlim’和‘Hannibal’的嫩茎质量最好。嫩茎质量最差的品种依次是‘Jacq.Ma2004’、‘Gloria’、‘Jacq.Ma2014’和‘Tsuki-kho3’。[结论]综合考虑产量与质量,在波兰气候条件下,最适宜的绿芦笋品种为‘Gynlim’、‘Hannibal’、‘Ravel’和‘Grolim’,而‘Gloria’、‘Tsuki-kho3’、‘PurplePassion’、‘Jacq.Ma2014’和‘Sartaguda’不适合波兰种植。 | 祝清俊 陈蕾蕾 孙欣 张奇志 Mikolaj Knaflewski Wodzimierz Krzesiński | 2013 | Agricultural Science & Technology2013，14，2： | 5 |
| 6 | IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C显示文摘AIM:To evaluate the effect of single nucleotide polymorphisms of interleukin(IL)-28B,rs12979860 on progression and treatment response in chronic hepatitis C.METHODS:Patients(n = 64;37 men,27 women;mean age,44 ± 12 years) with chronic hepatitis C,genotype 1,received treatment with peg-interferon plus ribavirin.Genotyping of rs12979860 was performed on peripheral blood DNA.Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment.Serum viral load,aminotransferase activity,and insulin level were measured.Insulin resistance index,body mass index,waist/hip ratio,percentage of body fat and fibrosis progression rate were calculated.Applied dose of interferon and ribavirin,platelet and neutrophil count and hemoglobin level were measured.RESULTS:A sustained virological response(SVR) was significantly associated with IL28B polymorphism(CC vs TT allele:odds ratio(OR),25;CC vs CT allele:OR,5.4),inflammation activity(G < 1 vs G > 1:OR,3.9),fibrosis(F < 1 vs F > 1:OR,5.9),platelet count(> 200 × 10 9 /L vs < 200 × 10 9 /L:OR,4.7;OR in patients with genotype CT:12.8),fatty liver(absence vs presence of steatosis:OR,4.8),insulin resistance index(< 2.5 vs > 2.5:OR,3.9),and baseline HCV viral load(< 10 6 IU/mL vs > 10 6 IU/mL:OR,3.0).There was no association with age,sex,aminotransferases activity,body mass index,waist/hip ratio,or percentage body fat.There was borderline significance(P = 0.064) of increased fibrosis in patients with the TT allele,and no differences in the insulin resistance index between groups of patients with CC,CT and TT alleles(P = 0.12).Spearman's rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605,respectively(P < 0.001).Significant differences were found in the insulin resistance index(P = 0.01) between patients with and without steatosis.Patients with the CT allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon(P = 0.07).CONCLUSION:IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy.Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients. | Andrzej Ciela Monika Bociaga-Jasik Iwona Sobczyk-Krupiarz Mikolaj K Glowacki Danuta Owczarek Dorota Cibor Marek Sanak Tomasz Mach | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 7 | The punctured droplet electrode -- A new three-phase elecrode with well defined geometry显示文摘 | ELZBIETA B MIKOLAJ D ZBIGNIEW S | 2007 | Electro Chem Commun2007，9，： | 1 |
| 8 | Stochastic P systems and the simulation of biochemical processes with dynamic compartments显示文摘 | ANTOINE S OLIVIER M MIKOLAJ C | 2008 | Biosystems2008，91，3： | 1 |
| 9 | Production of xan- than gum by sphingomonas bacteria carrying genes from Xan- thomonas campestris 显示文摘 | Pollock T J Mikolaj czak M Yamazaki M | 1997 | Industr Microbiol Biotechnol1997，19，2： | 1 |
| 10 | Tests on the Non-Linear Creep of Concrete 显示文摘 | Adam Mitzel Mikolaj Klapoc | 1968 | Build Sci1968，3，： | 1 |
| 11 | Impairment of Endothelium-Dependent Vasodilation of Resistance Vessels in Patients With Obstructive Sleep Apnea显示文摘 | Masahiko Kato Philip Roberts-Thomson Bradley G. Phillips William G. Haynes Mikolaj Winnicki Valentina Accurso Virend K. Somers | 2000 | Circulation: Journal of the American Heart Association2000，，21： | 1 |
| 12 | Bone Metabolism in Cholestatic Children Before and After Living-Related Liver Transplantation—a Long-Term Prospective Study显示文摘 | Edyta Kryskiewicz Joanna Pawlowska Pawel Pludowski Hor Ismail Elzbieta Karczmarewicz Mikolaj Teisseyre Ewa Skorupa Jozef Ryzko Piotr Kalicinski Jerzy Socha Roman S. Lorenc | 2012 | Journal of Clinical Densitometry2012，，2： | 1 |
| 13 | Ultrasonic determination of the particle size dis-tribution in water-based magnetic liquid 显示文摘 | Tomasz Homowski Arkadiusz Jozefczak Mikolaj Labowski An-drzej Skumiel | 2008 | Ultrasonics2008，48，： | 1 |
| 14 | Strategies for enhancing the performance of carbon/carbon supercapacitors in aqueous electrolytes显示文摘 | Krzysztof Fic Mikolaj Meller Elzbieta Frackowiak | 2013 | Electrochimica Acta2013，，： | 1 |
| 15 | Latent Space Phenotyping:Automatic Image-Based Phenotyping for Treatment Studies显示文摘Association mapping studies have enabled researchers to identify candidate loci for many important environmental tolerance factors,including agronomically relevant tolerance traits in plants.However,traditional genome-by-environment studies such as these require a phenotyping pipeline which is capable of accurately measuring stress responses,typically in an automated highthroughput context using image processing.In this work,we present Latent Space Phenotyping(LSP),a novel phenotyping method which is able to automatically detect and quantify response-to-treatment directly from images.We demonstrate example applications using data from an interspecific cross of the model C_(4) grass Setaria,a diversity panel of sorghum(S.bicolor),and the founder panel for a nested association mapping population of canola(Brassica napus L.).Using two synthetically generated image datasets,we then show that LSP is able to successfully recover the simulated QTL in both simple and complex synthetic imagery.We propose LSP as an alternative to traditional image analysis methods for phenotyping,enabling the phenotyping of arbitrary and potentially complex response traits without the need for engineering-complicated image-processing pipelines. | Jordan Ubbens Mikolaj Cieslak Przemyslaw Prusinkiewicz Isobel Parkin Jana Ebersbach Ian Stavness | 2020 | Plant Phenomics2020，2，1： | 1 |
| 16 | Electrochemistry Serving People and Nature: High‐Energy Ecocapacitors based on Redox‐Active Electrolytes显示文摘 | Elzbieta Frackowiak Krzysztof Fic Mikolaj Meller Grzegorz Lota | 2012 | ChemSusChem2012，，7： | 1 |
| 17 | Explaining the protec- tive effect of trait emotional intelligence regarding occupational stress: Exploration of emotional labor processes 显示文摘 | Mikolaj czak M C16mentine M Olivier L | 2007 | Joumal of Research in Personality2007，41，05： | 1 |
| 18 | A Comparison of Affine Region Detectors显示文摘 | Mikolaj czyk K Tuytelaars T Schmid C | 2004 | International Journal of Computer Vision2004，，： | 1 |
| 19 | A GIS-based model for testing effects of restoration measures in wetlands:A case study in the Kampinos National Park, Poland 显示文摘 | Mikolaj Piniewski Lars Gottschalk | 2012 | Ecological Engineering2012，，44： | 1 |
| 20 | Electrodeposition and properties of Ni - W, Fe - W and Fe - Ni - W amorphous alloys, a comparative study 显示文摘 | Mikolaj Donten Henrikas Cesiulis Zbigniew Stojek | 2000 | Electrochimica Acta2000，45，： | 1 |
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