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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Repaid tumor penetration of a single-chain Fv and comparison with other immunoglobulin from显示文摘 | Yokota T Milenic DE Withlow M | 1992 | Cancer Res1992，52，14： | 2 |
| 3 | In vivo evaluation of bismuth-labeled monoelonal antibody comparing DTPA-derived bifunctional chelates显示文摘 | MILENIC D E ROSELLI M MIRZADEH S | 2001 | Radiopharrn2001，16，： | 1 |
| 4 | An improved selection strategy and the use of acetosyringone in shoot induction medium increase almond transformation efficiency by 100-fold显示文摘 | MILENE S C CE L M OLIVEIR A M M | 2006 | Plant Cell Tissue and Organ Culture2006，85，： | 1 |
| 5 | Structural correlates of an antieareinoma antibody: identification of specificity-determining residues (SDRs) and development of a minimally immunogenic antibody variant by retention of SDRs only显示文摘 | Tamura M Milenic DE Iwahashi M | 2000 | J Immunol2000，164，3： | 1 |
| 6 | Genetic diversity in soybean germplasm identified by SSR and EST-SSR markers显示文摘 | Bruno M M Milene M Maria I Z | 2010 | Pesq Agropec Bras2010，45，3： | 1 |
| 7 | Reproductive and possible hormonal effects of carbendazim显示文摘 | ELKIANE M R SIMONE B MILENE L ~ | 2014 | Regulatory Toxicology and Pharmacology2014，69，： | 1 |
| 8 | Study of Heavy Metal Pollution in Sediments from the Iron Gate ( Danube River ),Serbia and Montenegro 显示文摘 | MILEN KOVIC N DAMJANOVIC M | 2005 | Polish Journal of Environmental Studies2005，14，6： | 1 |
| 9 | CDR substitutions of a humanized monoclonal antibody (CC49):contributions of individual CDRs to antigen binding and immunogenicity显示文摘 | Iwahashi M Milenic DE Padlan EA | 1999 | Mol Immunol1999，36，： | 1 |
| 10 | Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms显示文摘 | Yokota T Milenic DE Whitlow M | 1992 | Cancer Res1992，52，12： | 1 |
| 11 | Antibody-targeted radiation cancer therapy 显示文摘 | Milenic D E Brady E D Brechbiel M W | 2004 | Nat Rev Drug Discov2004，3，6： | 1 |
| 12 | Rapid tumor penetration of a single-chain Fv and comparison with other immunoglohulin forms 显示文摘 | Yokota T Milenic D E Whitlow M | 1992 | Cancer Res1992，52，12： | 1 |
| 13 | CDR substitutions of a humanized monoclonal antibody ( CC49 ) : contributions of individual CDRs to antigen binding and immunogenicity 显示文摘 | Iwahashi M Milenic DE Padlan EA | 1999 | Mol Immunol1999，36，1516： | 1 |
| 14 | Rapid tumor penetration of a single-chain Fy and comparison with other immunoglobulin forms显示文摘 | Yokota T Milenic DE Whidow M | 1992 | Cancer Research1992，52，： | 1 |
| 15 | Value of echocardiographic measurement of left ventrieular mass in predicting cardiovascular morbid events in hypertensive man显示文摘 | Casale PN Devereux RB Milener M | 1986 | Ann Intern Med1986，105，： | 1 |
| 16 | Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms显示文摘 | Yokota T Milenic DE Whitlow M | 1992 | Cancer Res1992，52，12： | 1 |
| 17 | Rapid tumor penetration of single-chain Fv and comparison with other immunoglobulin forms显示文摘 | Yokota T Milenic DE Whitlow M | 1992 | Cancer Res1992，52，12： | 1 |
| 18 | Rapid tumor penetration of a singer-chain Fv and comparison with other immunoglobulin forms 显示文摘 | Yokota T Milenic D E Whitlow M | 1992 | Cancer Res1992，52，： | 1 |
| 19 | Rapid tumor penetration of a single-chain Fv and comparison with other immunoglubin forms显示文摘 | Yokata T Milenic DE Whitlow M | 1992 | Cancer Research1992，52，： | 1 |
| 20 | Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms 显示文摘 | Yokota T Milenic DE Whitlow M | 1992 | Cancer Res1992，52，12： | 1 |
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