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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Effect of EM Bokashi application on control of secondary soil salinization显示文摘In order to ameliorate saline-alkaline soil, EM Bokashi has been applied to rice production in conjunction with subdrainage in Ningxia Autonomous Region and Zhejiang Province. The preliminary results can be summarized as follows: EM Bokashi can increase soil organic matter content, improve soil porosity and permeability, and raise the soil's levels of available nutrients; and EM Bokashi combined with subdrainage treatment is more effective in controlling secondary soil salinization and raising the grain yield and quality than other treatments. The results suggest that EM Bokashi can reduce the necessary amount of chemical fertilizer application, thereby improving the agricultural environment, and that the introduction of EM Bokashi into systems of secondary soil salinization control systems has resulted in significant benefits. | Shao Xiaohou Tan Min Jiang Ping Cao Weiling | 2008 | Water Science and Engineering2008，1，4： | 3 |
| 3 | Comparative study on cultivation of microalgae for nutrient removal and lipid production in different artificial wastewaters显示文摘Wastewater contains high concentration of nutrients,like nitrogen and phosphorus,which have been identified as the main reasons for water eutrophication and serious ecological issues.Therefore,cultivating a tolerant and adaptive microalgae strain in wastewater is considered as a promising approach for sustainable biomass/lipid production.The potential usages of Desmodesmus sp.for biomass and lipid production within different artificial wastewater(AW)were investigated and the removal efficiencies of nutrient were compared.The maximum removal rate of chemical oxygen demand,ammonia nitrogen,nitrate nitrogen and phosphate were 272 mg/(L·d),14.021 mg/(L·d),7.774 mg/(L·d)and 3.347 mg/(L·d),respectively in AW2,AW3,AW5 and AW2.Maximum biomass(1.159 g/L)and lipid(280 mg/L)productions were observed in AW5,while the highest lipid content achieved was 37.42%in AW1.Fatty acid analysis showed that lipids extracted from AW-cultivated Desmodesmus sp.contained 59.57%-77.79%polyunsaturated fatty acids(30.6%-44.47%was linoleic acid). | Hao Rui Yu Zhen Li Jinchen Gao Min Ma Weiling Zhu Yi | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 1 |
| 4 | Analysis of Basic Design in Architectural Structure Design显示文摘In recent years,with the rapid development of urban development and the continuous improvement of people's living standards,China's construction industry has also achieved remarkable development.In order to meet the needs of urbanization,many large buildings and high-rise buildings have been built up.These buildings are usually large,so they put forward higher and higher requirements for the technical level of engineering construction.Whether it is for the stability or safety of buildings,it must be continuously improved.Basic design is a key part of the structural design of a building.For the safety of buildings,natural disasters or accidental injuries can have extremely bad effects on urban development and people's life.This paper briefly discusses the basic design analysis in architectural structure design,and seeks the key technology in this process to provide a guarantee for the safety of the building. | Hongliang Xu Zhenzhong Huo Weiling Zhu Min Yang Jianhua Xu | 2018 | Smart Construction Research2018，2，4： | 0 |
| 5 | Unique mutation spectrum of progressive pseudorheumatoid dysplasia in the Chinese population:a retrospective genotype-phenotype analysis of 105 patients显示文摘Background Progressive pseudorheumatoid dysplasia(PPRD)is a rare genetic disease with autosomal recessive inherit-ance.There was a lack of genotype-phenotype correlation data from the Chinese population.This study aimed to identify the genotype and phenotype characteristics of Chinese PPRD patients and to conduct a genotype-phenotype analysis of Chinese PPRD patients.Methods Genetic analysis was performed for suspected PPRD patients from Peking Union Medical College Hospital.Medi-cal records were collected from the electronic medical record system and patient-held portable health records.Published Chinese PPRD cases were gathered from both international and Chinese local databases.We collected demographic infor-mation,genetic variants,clinical manifestations,and imaging characteristics for further analysis.Results We included 105 Chinese PPRD patients in the current study.Thirty-three variants,including nine novels and five hotspot variants,were identified,with 26/33(79%)variants exclusively seen in the Chinese population.Chinese PPRD patients share a phenotype similar to that in international reports.Joint involvement may progress with age(R2=0.2541).Long bone shortening and severe deformities occur in three patients with biallelic null variants,of which at least one vari-ant is located in exon 2.Among hotspot variants,c.624dupA(p.C209Mfs*21)were associated with later onset and more involved joints.Elbow joints were more likely to be affected in patients carrying c.624dupA(p.C209Mfs*21)and c.866dupA(p.S209Efs*13).Shoulder joints are more likely to be involved in patients with biallelic null variants(P=0.027).Conclusions Chinese PPRD patients share a unique mutation spectrum.Among the five hotspot variants,c.624dupA is associated with later onset of disease,more extensive joint involvement,and a tendency to affect elbow joints.Biallelic null variants with at least one variant in exon 2 could be a likely cause of long bone shortening and severe deformities. | Wei Wang Si-Hao Gao Min Weil Lin-Qing Zhong Wei Liu Shan Jian Juan Xiao Cai-Hui Zhang Jian-Guo Zhang Xiao-Feng Zeng Wei-Bo Xia Zheng-Qing Qiu Hong-Mei Song | 2023 | World Journal of Pediatrics2023，19，7： | 0 |
| 6 | Effect of Reducing Application of Chemical Fertilizers and Chemical Pesticides on Physiological Traits,Yield and Quality of Radish显示文摘This paper studied the effect of reducing application of chemical fertilizer,increasing application of functional organic fertilizer and trace elements and fully using biological pesticides on physiological traits,yield and quality of radish. The results showed that applying functional organic fertilizer and trace elements and fully using biological pesticides could help to significantly improve the radish fleshy root yield,increase soluble sugar and vitamin C content,reduce crude fiber and nitrate content,but had no significant influence on radish moisture content,glucosinolates and chlorpyrifos content in organophosphorus pesticides. | Weiling YUAN Shangyong YUAN Caixia GAN Lei CUI Zhongjiu JIAO Yong MIN Fengjuan ZHU Zhengming QIU | 2016 | Asian Agricultural Research2016，8，10： | 0 |
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