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| 1 | A nonlinear rheological model of backfill material for retaining roadways and the analysis of its stability显示文摘The long-term stability of backfill material is the key to retaining roadways successfully.In order to study the rheological deformation of backfill material and its long-term stability,given the visco-elastoplastic properties of this material,we introduced a softening and a hardening function for a new nonlinear rheological model with time-varying parameters.Based on this,we presented the instability condition of this model by using the principle of minimum potential energy.Combined with engineering practice,we calculated the unstable time period of backfill material.The results show that the time of instability of the backfill material relate to the initial parameters of the material,the coefficients decided by temperature and the ratio of the plastic zone of the backfill material.Based on the results of our analysis from the point of view of energy,we can quickly obtain the time of instability of this model from our graphical analysis.The time of instability of the backfill material obtained from our investigation coincides with an actual project. | Zhang Tianjun Ma Mina Wang Hongsheng Xu Hongjie | 2011 | Mining Science and Technology2011，21，4： | 5 |
| 2 | Neurotoxicity of levodopa on catecholamine-rich neurons显示文摘 | Parso B Casarejos MJ | 1992 | Mov Disord1992，7，： | 1 |
| 3 | Separation and determination of flavonoids in Lamiophlomis rotata by capillary electrophoresis using borate as electrolyte显示文摘 | Luo Mina Lu Huawei Ma Huaqiao | 2007 | J Pharmaceut Biomed2007，44，4： | 1 |
| 4 | Neurotoxicity of levodopa on catecholamine-rich neurons显示文摘 | Mina MA Parso B Casarejos MJ | 1992 | Mov Disord1992，7，： | 1 |
| 5 | Separation and de-termination of flavonoids in Lamiophlomis rotata by capillary e-lectrophoresis using borate as electrolyte显示文摘 | Luo Mina Lu Huawei Ma Huaqiao | 2007 | J Pharmaceut Bi-omed2007，44，4： | 1 |
| 6 | Phase Ⅲ trial of cisplatin(P) plus etoposide (E) plus concurrent chest radiation (XRT) with or without consolidation docetaxel (D) in patients (pts) with inoperable stage Ⅲ non-small cell lung cancer ( NSCLC ) : HOG LUN 01-24/USO-023-Updated results 显示文摘 | Mina LA Neubauer MA Ansari RH | 2008 | J Clin Oncol2008，，： | 1 |
| 7 | Phase III trial of cisplatin (P) plus etoposid (E) plus concurrent chest radia- tion (CRT) in patient (PTS) with or without consolidation docetaxel(D) in patients(pts) with inoperable stage Ⅲ non - small cem ung cancer(NSCLC) :HOU LUN 01-24/USO- 023-Updated results显示文摘 | Mina LA Neeubauer MA Ansafi RH | 2008 | J Clin Oncol2008，，： | 1 |
| 8 | Portal vein thrombosis in adults undergoing liver transplantation:risk factors,screening,management,and outcome显示文摘 | Yerdel MA Gunson B Mina D | 2000 | Transplantation2000，69，9： | 1 |
| 9 | Efficacy Differences of First-line EGFR-TKIs Alone vs in Combination with Chemotherapy in Advanced Lung Adenocarcinoma Patients with Sensitive EGFR Mutation and Concomitant Non-EGFR Genetic Alterations显示文摘Background and objective:Epidermal growth factor receptor(EGFR)mutations are often associated with non-EGFR genetic alterations,which maybe a reason for the poor efficacy of EGFR tyrosine kinase inhibitors(TKIs).Here we conducted this study to explore whether EGFR-TKIs combined with chemotherapy would benefit advanced lung adenocarcinoma patients with both sensitive EGFR mutation and concomitant non-EGFR genetic alterations.Materials and methods:Cases of advanced lung adenocarcinoma with EGFR mutation combined with concomitant nonEGFR genetic alterations were retrospectively collected.And the patients were required to receive first-line EGFR-TKIs and chemotherapy combination or EGFR-TKIs monotherapy.Demographic,clinical and pathological data were collected,and the electronic imaging data were retrieved to evaluate the efficacy and time of disease progression.Survival data were obtained through face-to-face or telephone follow-up.The differences between the two groups in objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS)and overall survival(OS)were investigated.Results:107 patients were included,including 63 cases in the combination group and 44 cases in the monotherapy group.The ORR were 78%and 50%(P=0.003),and DCR were 97%and 77%(P=0.002),respectively.At a median follow-up of 13.7 mon,a PFS event occurred in 38.1%and 81.8%of patients in the two groups,with median PFS of18.8 mon and 5.3 mon,respectively(P<0.000,1).Median OS was unreached in the combination group,and 27.8 mon in the monotherapy group(P=0.31).According to the Cox multivariate regression analysis,combination therapy was an independent prognostic factor of PFS.Conclusion:In patients with EGFR-mutant advanced lung adenocarcinoma with concomitant non-EGFR genetic alterations,combination of TKIs and chemotherapy was significantly superior to EGFR-TKIs monotherapy,which should be the preferred treatment option. | Guowei ZHANG Ruirui CHENG Yuanyuan NIU Huijuan WANG Xiangtao YAN Mina ZHANG Xiaojuan ZHANG Jinpo YANG Chunhua WEI Zhiyong MA | 2022 | 中国肺癌杂志2022，25，9： | 0 |
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