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| 1 | Treatment of hepatocellular carcinoma accompanied by portal vein tumor thrombus显示文摘The prognosis of patients with hepatocellular carcinoma (HCC) accompanied by portal vein tumor thrombus (PVTT) is generally poor if left untreated: a median survival time of 2.7-4.0 mo has been reported. Furthermore, while transcatheter arterial chemoembolization (TACE) has been shown to be safe in selected patients, the median survival time with this treatment is still only 3.8-9.5 mo. Systemic single-agent chemotherapy for HCC with PVTT has failed to improve the prognosis, and the response rates have been less than 20%. While regional chemotherapy with low-dose cisplatin and 5-fluorouracil or interferon and 5-fluorouracil via hepatic arterial infusion has increased the response rate, the median survival time has not exceeded 12 (range 4.5-11.8) mo. Combined treatment consisting of radiation for PVTT and TACE for liver tumor has achieved a high response rate, but the median survival rates have still been only 3.8-10.7 mo. With hepatic resection as monotherapy, the 5-year survival rate and median survival time were reportedly 4%-28.5% and 6-14 mo. The most promising results were reported for combined treatments consisting of hepatectomy and TACE, chemotherapy, or internal radiation. The reported 5-year survival rates and median survival times were 42% and 31 mo for TACE followed by hepatectomy; 36.3% and 22.1 mo for hepatectomy followed by hepatic arterial infusion chemotherapy; and 56% for chemotherapy or internal radiation followed by hepatectomy. | Masami Minagawa Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，47： | 74 |
| 2 | Effect of periodontal treatment on adipokines in type 2 diabetes显示文摘The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvement of adipokines in diabetic patients. In summary, substantial evidence suggests that diabetes is associated with increased prevalence, extent and severity of periodontitis. Numerous mechanisms have been elucidated to explain the impact of diabetes on the periodontium. However, current knowledge concerning the role of major adipokines indicates only some of their associations with the pathogenesis of periodontitis in type 2 diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have positive effects on the diabetic condition, although evidence for this remains somewhat equivocal. | Hiroshi Ogawa Teerasak Damrongrungruang Sayaka Hori Kaname Nouno Kumiko Minagawa Misuzu Sato Hideo Miyazaki | 2014 | World Journal of Diabetes2014，5，6： | 8 |
| 3 | Prognostic Impact of Anatomic Resection for Hepatocellular Carcinoma显示文摘 | Kiyoshi Hasegawa Norihiro Kokudo Hiroshi Imamura Yutaka Matsuyama Taku Aoki Masami Minagawa Keiji Sano Yasuhiko Sugawara Tadatoshi Takayama Masatoshi Makuuchi | 2005 | Annals of Surgery2005，，2： | 6 |
| 4 | Stapled gastro/duodenojejunostomy shortens reconstruction time during pylorus-preserving pancreaticoduodenectomy显示文摘AIM:To investigate whether a stapled technique is superior to the conventional hand-sewn technique for gastro/duodenojejunostomy during pylorus-preserving pancreaticoduodenectomy(PpPD).METHODS:In October 2010,we introduced a mechanical anastomotic technique of gastro-or duodenojejunostomy using staplers during PpPD.We compared clinical outcomes between 19 patients who underwent PpPD with a stapled gastro/duodenojejunostomy(stapled anastomosis group)and 19 patients who underwent PpPD with a conventional hand-sewn duodenojejunostomy(hand-sewn anastomosis group).RESULTS:The time required for reconstruction was significantly shorter in the stapled anastomosis group than in the hand-sewn anastomosis group(186.0±29.4 min vs 219.7±50.0 min,P=0.02).In addition,intraoperative blood loss was significantly less(391.0±212.0 mL vs 647.1±482.1 mL,P=0.03)and the time to oral intake was significantly shorter(5.4±1.7d vs 11.3±7.9 d,P=0.002)in the stapled anastomosis group than in the hand-sewn anastomosis group.There were no differences in the incidences of delayed gastric emptying and other postoperative complications between the groups.CONCLUSION:These results suggest that stapled gastro/duodenojejunostomy shortens reconstruction time during PpPD without affecting the incidence of delayed gastric emptying. | Norihiro Sato Kei Yabuki Shiro Kohi Yasuhisa Mori Noritaka Minagawa Toshihisa Tamura Aiichiro Higure Koji Yamaguchi | 2013 | World Journal of Gastroenterology2013，19，48： | 6 |
| 5 | Calcium signaling in cholangiocytes显示文摘Cytosolic Ca2+ 是在房间的几乎每种类型的一个重要的秒送信人。而且, Ca2+ 通常在单个房间以内调整多重活动。这篇文章考察为在 cholangiocytes 发信号的 Ca2+ 负责的细胞的机械。另外,在 cholangiocytes 的二个调停 Ca2+ 的事件被讨论:酸式碳酸盐分泌物和 apoptosis。最后,新兴的证据被考察发信号的 Ca2+ 涉及影响表明小径的胆汁的树和那 Ca2+ 的疾病的致病,这能在胆汁郁积的混乱的治疗被操作到治疗学的优点。 | Noritaka Minagawa Barbara E Ehrlich Michael H Nathanson | 2006 | World Journal of Gastroenterology2006，12，22： | 4 |
| 6 | Novel technique of abdominal wall nerve block for laparoscopic colostomy: Rectus sheath block with transperitoneal approach显示文摘A 62-year-old man who had acute rectal obstruction due to a large rectal cancer is presented. He underwent emergency laparoscopic colostomy. We used the laparoscopic puncture needle to inject analgesia with the novel transperitoneal approach. In this procedure, both ultrasound and laparoscopic images assisted with the accurate injection of analgesic to the correct layer. The combination of laparoscopic visualization and ultrasound imaging ensured infiltration of analgesic into the correct layer without causing damage to the bowel. Twentyfour hours postoperatively, the patient's pain intensity as assessed by the numeric rating scale was 0-1 during coughing, and a continuous intravenous analgesic was not needed. Colostomy is often necessary in colon obstruction. Epidural anesthesia for postoperative pain cannot be used in patients with a coagulation disorder. We report the use of a novel laparoscopic rectus sheath block for colostomy. There has been no literature described about the nerve block with transperitoneal approach. The laparoscopic rectus sheath block was performed safely and had enough analgesic efficacy for postoperative pain. This technique could be considered as an optional anesthetic regimen in acute situations. | Jun Nagata Jun Watanabe Yusuke Sawatsubashi Masaki Akiyama Koichi Arase Noritaka Minagawa Takayuki Torigoe Kotaro Hamada Yoshifumi Nakayama Keiji Hirata | 2017 | World Journal of Gastrointestinal Surgery2017，9，8： | 2 |
| 7 | Hepatocyte growth factor and transforming growth factor β1 contribute to regeneration of small-for-size liver graft immediately after transplantation显示文摘 | Mizuki Ninomiya Noboru Harada Satoko Shiotani Shoji Hiroshige Ryosuke Minagawa Yuji Soejima Taketoshi Suehiro Takashi Nishizaki Mitsuo Shimada Keizo Sugimachi | 2003 | Transplant International2003，，11： | 2 |
| 8 | Selection Criteria for Hepatectomy in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombus显示文摘 | Masami Minagawa Masatoshi Makuuchi Tadatoshi Takayama Kuni Ohtomo | 2001 | Annals of Surgery2001，，3： | 2 |
| 9 | Feasibility study comparing docetaxel-cisplatin versus docetaxel-carboplatin as first-line chemotherapy for ovarian cancer 显示文摘 | Minagawa Y Kigawa J Kanamori Y | 2006 | Gynecol Oncol2006，101，3： | 1 |
| 10 | Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer:long-term results显示文摘 | Minagawa M Makuuehi M Torzilli G | 2000 | Ann Surg2000，231，4： | 1 |
| 11 | Clinical study of pazufloxacin mesilate, a new quinolone antibacterial agent, in burn infections and tissue concentrations显示文摘 | Sugihara T Yoshida T Minagawa H | 2000 | Jpn J Chemother2000，48，： | 1 |
| 12 | Gamma-glutamyl eysteine synthetase up-regulates glutathione and multidrug resistance- associated protein in patients with ehemoresistant epithelia显示文摘 | Kigawa J Minagawa Y Cheng X | 1998 | Clin Cancer Res1998，4，7： | 1 |
| 13 | Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy显示文摘 | Imamura H Matsuyama Y Tanaka E Ohkubo T Hasegawa K Miyagawa S Sugawara Y Minagawa M Takayama T Kawasaki S Makuuchi M | | 0，，02： | 1 |
| 14 | Differentiation of Smooth Muscle Cells from Human Amniotic Mesenchymal Cells Implanted in the Freeze-Injured Mouse Urinary Bladder显示文摘 | Minagawa T Imamura T Igawa Y | | 0，，： | 1 |
| 15 | N2 fixation variability in the oligotrophic Sulu Sea, western equatorial Pacific region over the past 83 kyr显示文摘 | HORIKAWA K MINAGAWA M KATO Y | 2006 | Journal of Oceanography2006，62，： | 1 |
| 16 | Immunohistochemical localization of interferon-gamma in normal human ovary 显示文摘 | Grasso G Asano A Minagawa T | 1994 | Gynecol Endocrinol1994，8，3： | 1 |
| 17 | Selection criteria for hepatectomy in patients with hepatocellular carcinoma and portal vein tumor thrombus显示文摘 | Minagawa M Makuuchi M Takayama T | 2001 | Ann Surg2001，233，： | 1 |
| 18 | 390 MPa yield strength steel plate for large heat - input welding for large container ships 显示文摘 | Minagawa M Ishida K Funatsu Y | 2004 | Nippon Steel Technical Report2004，380，： | 1 |
| 19 | Super High HAZ Toughness Steels with Fine Microstructure Imparted by Fine Particles显示文摘 | Kojima A Uemori R Minagawa M | 2003 | Materia Japan2003，42，1： | 1 |
| 20 | Chemosensitivity and p53-dependent apoptosis in epithelial ovarian carcinoma显示文摘 | Sato S Kigawa J Minagawa Y | 1999 | Cancer1999，86，7： | 1 |
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