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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Use of high resolution 13C-NMR to examine the enzymatic covalent binding of 13C-labeled 2,4-dichlorophenol to humic substances 显示文摘 | HATCHER P G BORTIAYNSKI J M MINARD R D | 1993 | Environmental Science & Technology1993，27，10： | 1 |
| 3 | Anaerobic metabolism of the herbicide butachlor in soil显示文摘 | Lee J K Minard R D Bollay J M | 1982 | Hanguk Nonghwa Hakhoe Chi1982，25，2： | 1 |
| 4 | Biological and chemical interactions of pesticides with soil organic matter显示文摘 | Bollag J M Myers C J Minard R D | 1992 | Science of the Total Environment1992，，9： | 1 |
| 5 | Control of heat casualties at military training centers显示文摘 | Yaglou C P Minard D | 1957 | AMA Archives of Industrial Health1957，16，4： | 1 |
| 6 | Controt of heat casualties at military training centers显示文摘 | Yaglou C P Minard D | | Archives of Industrial Health0，16，30： | 1 |
| 7 | (-)-Corydalisol:a new secoberbine alkaloid显示文摘 | G?zler T ?nür M A Minard R D | 1983 | J Nat Prod1983，46，3： | 1 |
| 8 | Magnetic resonance imaging (MRI) of PEM dehydration and gas manifold flooding during continuous fuel cell op- eration显示文摘 | MINARD K R VISWANATHAN V V PAUL D | 2006 | Journal of Power Sources2006，161，2： | 1 |
| 9 | Comparison of dehydrogenase polymer(DHP) lignin with native lignin from gymnosperm wood by thermochemolysis using tetramethylammonium hydroxide(TMAH) 显示文摘 | HATCHER P G MINARD R D | 1996 | Organic Geochemistry1996，24，67： | 1 |
| 10 | Bacterial me- tabolism of 1-naphthol 显示文摘 | Bollag J M Czaplicki E J Minard R D | 1975 | J Agric Food Chem1975，23，1： | 1 |
| 11 | Anaerobic metabolism of the herbicide butachlor in soil 显示文摘 | Lee J K Minard R D Bollay J M | 1982 | Hanguk Nonghwa Hakhoe Chi1982，25，2： | 1 |
| 12 | Bound pesticide residues in soils: Areview显示文摘 | Gevao B Semple K T Minard R D | 2000 | Environmental Pollution2000，108，： | 1 |
| 13 | Biological and chemical interaction of pesticide with soils显示文摘 | BOLLAG J MYERS C J MINARD R D | 1992 | The Science of the Total Environment1992，123，： | 1 |
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