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| 1 | Molecular inte-gration of casanova in the Nodal signalling pathway con-trolling endoderm formation 显示文摘 | Aoki TO David NB Minchiotti G | 2002 | Development2002，129，2： | 1 |
| 2 | Control of embryonic stem cell metastability by L-proline catabolism显示文摘The molecular mechanisms controlling mouse embryonic stem cell(ESC)metastability,i.e.their capacity to fluctuate between different states of pluripotency,are not fully resolved.We developed and used a novel automation platform,the Cellmaker,to screen a library of metabolites on two ESC-based phenotypic assays(i.e.proliferation and colony phenotype)and identified two metabolically related amino acids,namely L-proline(L-Pro)and L-ornithine(L-Orn),as key regulators of ESC metastability.Both compounds,but mainly L-Pro,force ESCs toward a novel epiblast stem cell(EpiSC)-like state,in a dose-and time-dependent manner.Unlike EpiSCs,L-Pro-induced cells(PiCs)contribute to chimeric embryos and rely on leukemia inhibitor factor(LIF)to self-renew.Furthermore,PiCs revert to ESCs or differentiate randomly upon removal of either L-Pro or LIF,respectively.Remarkably,PiC generation depends on both L-Pro metabolism(uptake and oxidation)and Fgf5 induction,and is strongly counteracted by antioxidants,mainly L-ascorbic acid(vitamin C,Vc).ESCs↔PiCs phenotypic transition thus represents a previously undefined dynamic equilibrium between pluripotent states,which can be unbalanced either toward an EpiSC-like or an ESC phenotype by L-Pro/L-Orn or Vc treatments,respectively.All together,our data provide evidence that ESC metastability can be regulated at a metabolic level. | Laura Casalino Stefania Comes Giuseppina Lambazzi Benedetta De Stefano Stefania Filosa Sandro De Falco Dario De Cesare Gabriella Minchiotti Eduardo Jorge Patriarca | 2011 | Journal of Molecular Cell Biology2011，3，2： | 1 |
| 3 | Cripto:a tumor growth factor and more显示文摘 | Adamson ED Minchiotti G Salomon DS | 2002 | J Cell Physiol2002，190，3： | 1 |
| 4 | Human serum albumin isoforms: Genetic and molecular aspects and functional consequences显示文摘 | Ulrich Kragh-Hansen Lorenzo Minchiotti Monica Galliano Theodore Peters | 2013 | BBA - General Subjects2013，，： | 1 |
| 5 | Structural and biochemical characterization of a new type of lectin isolated from carp eggs 显示文摘 | Galliano M Minchiotti L Campagnoli M | 2003 | Biochemical Journal2003，376，： | 1 |
| 6 | High-affinity binding of warfarin,salicylate and diazepam to natural mutants of human serum albumin modified in the C-terminal end显示文摘 | Vestberg K Galliano M Minchiotti L Kragh-Hansen U | 1992 | Biochem Pharma1992，44，： | 1 |
| 7 | Mutations and polymorphisms of the gene of the major human blood protein serum albumin显示文摘 | Minchiotti L Galliano M Kragh-Hansen U | 2008 | Hum Mutat2008，29，8： | 1 |
| 8 | Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications显示文摘 | Antonietta Coppola Antonio Romito Christelle Borel Corinne Gehrig Maryline Gagnebin Emilie Falconnet Antonella Izzo Lucia Altucci Sandro Banfi Stylianos E. Antonarakis Gabriella Minchiotti Gilda Cobellis | 2014 | Stem Cell Research2014，，： | 1 |
| 9 | Isolation of phospholipase A2 from soybean (Glycine max) seeds:The study of its enzymatic properties显示文摘 | Minchiotti M Scalambro M B Vargas L | 2008 | Enzyme and Microbial Technology2008，42，5： | 1 |
| 10 | Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development显示文摘 | Minchiotti G Parisi S Liguori G | 2000 | Eur J Biochem2000，90，2： | 1 |
| 11 | Cripto: a tumor growth factor and more显示文摘 | Adamson E D Minchiotti G Salomon D S | 2002 | J Cell Physiol2002，190，3： | 1 |
| 12 | A novel frameshift deletion in the albumin gene causes analbuminemia in a young Turkish woman显示文摘 | Dagnino M Caridi G Aydin Z Ozturk S Karaali Z Kazancioglu R Cefle K Gursu M Campagnoli M Galliano M Minchiotti L | | 0，，21： | 1 |
| 13 | Prospective multicenter demographic and epidemiological study on vernal keratoconjunctivitis:a glimpse of ocular surface in Italian population显示文摘 | Lambiase A Minchiotti S Leonardi A Secchi AG Rolando M Calabria G | | 0，，01： | 1 |
| 14 | Human idiopathic epiretinat membranes express NGF and NGF receptors 显示文摘 | Minchiotti S Stampachiacchiere B Micera A Lambiase A Ripandelli G Bini B | 2008 | Retina2008，28，4： | 1 |
| 15 | Nodal-dependant Cripto signaling in ES cells:from stem cells to tumor biology显示文摘 | Minchiotti G | 2005 | Oncogene2005，24，37： | 1 |
| 16 | Molecular diagnosis of analbuminemia:a new casc caused by a nonsense mutation in the albumin gene显示文摘 | Daqnino M Caridi G Haenni U Duss A Areqqer F Campaqnoli M Galliano M Minchiotti L | | 0，，11： | 1 |
| 17 | Congenital analbuminaemia: molecular defects and biochemical and clinical aspects显示文摘 | Minchiotti L Galliano M Caridi G | 2013 | Biochim Biopbys Acta2013，1830，12： | 1 |
| 18 | Cripto: a tumor growth factor and more显示文摘 | Adamson ED Minchiotti G Salomon DS | 2002 | J Cell Physiol2002，190，3： | 1 |
| 19 | A new proalbumin variants: albumin Jaffna(-1 Arg-Leu)显示文摘 | Galliano M Minchiotti L Stoppini M | 1989 | FEBS Lett1989，255，： | 1 |
| 20 | A nucleotide insertion and frameshift cause albumin kenitra, an extended and o-glycosylated mutant of human serum albumin with two addititional disulfide bridge显示文摘 | Minchiotti L Campagnoli M Rossi A | 2001 | Eur J Biochim2001，268，： | 1 |
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