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| 1 | Human NK cells: surface receptors, inhibitory checkpoints, and translational applications显示文摘NK cells play important roles in innate defenses against viruses and in the control of tumor growth and metastasis.The regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface receptors.In humans,major activating receptors involved in target cell killing are the natural cytotoxicity receptors(NCRs)and NKG2D.Activating receptors recognize ligands that are overexpressed or expressed de novo upon cell stress,viral infection,or tumor transformation.The HLA-class I-specific inhibitory receptors,including KIRs recognizing HLA-class I allotypic determinants and CD94/NKG2A recognizing the class-Ib HLA-E,constitute a fail-safe mechanism to avoid unwanted NK-mediated damage to healthy cells.Other receptors such as PD-1,primarily expressed by activated T lymphocytes,are important inhibitory checkpoints of immune responses that ensure T-cell tolerance.PD-1 also may be expressed by NK cells in cancer patients.Since PD-1 ligand(PD-L1)may be expressed by different tumors,PD-1/PD-L1 interactions inactivate both T and NK cells.Thus,the reliable evaluation of PD-L1 expression in tumors has become a major issue to select patients who may benefit from therapy with mAbs disrupting PD-1/PD-L1 interactions.Recently,NKG2A was revealed to be an important checkpoint controlling both NK and T-cell activation.Since most tumors express HLA-E,mAbs targeting NKG2A has been used alone or in combination with other therapeutic mAbs targeting PD-1 or tumor antigens(e.g.,EGFR),with encouraging results.The translational value of NK cells and their receptors is evidenced by the extraordinary therapeutic success of haploidentical HSCT to cure otherwise fatal high-risk leukemias. | Simona Sivori Paola Vacca Genny Del Zotto Enrico Munari Maria Cristina Mingari Lorenzo Moretta | 2019 | Cellular & Molecular Immunology2019，16，5： | 33 |
| 2 | What is a natural killer cell显示文摘 | Moretta A Bottino C Mingari MC | 2002 | Nat Immunol2002，3，： | 1 |
| 3 | Human interleukin-2 promotes proliferation of activated B cells via surface recepors similar to those of activated T cells显示文摘 | Mingari MC Gerosa F Carra G | 1984 | Nature1984，312，： | 1 |
| 4 | Human cytolytic T lymphocytes expressing HLA class-I-specific inhibitory receptors显示文摘 | Mingari MC Pietra G Moretta L | 2005 | Curr Opin Immunol2005，17，3： | 1 |
| 5 | Inhibitory receptors for HLA class I molecules on cytolytic T lymphocytes显示文摘 | M. C. Mingari M. Ponte C. Vitale F. Schiavetti S. Bertone L. Moretta | 1997 | International Journal of Clinical & Laboratory Research (-)1997，，2： | 1 |
| 6 | Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes 显示文摘 | Rolando M Barabino S Mingari C | 2005 | Cornea2005，24，： | 1 |
| 7 | Human natural killer cell function and their interactions with dendritic cells显示文摘 | Moretta L Ferlazzo G Mingari MC | 2003 | Vaccine2003，21，2： | 1 |
| 8 | What is a natural killer cell? 显示文摘 | Moretta A Bottino C Mingari MC | 2002 | Nat Immunol2002，3，1： | 1 |
| 9 | Regulation or KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses显示文摘 | Mingari M C Moretta A Moretta L | 1998 | Immunol Today1998，19，： | 1 |
| 10 | Expression of HLA class 1 specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controlled T-cell activation and funetion显示文摘 | Mingari M C Ponte M Vitale C | 2000 | Hum Immunol2000，61，： | 1 |
| 11 | Multiple HLA-class Ⅰ-specific inhibitory NK receptor expression and IL-4/IL-5 production by CD8 ±T-cell clones显示文摘 | MARIA-A MAVILIO COSTA P DIGNETTI FOGLI M MINGARI | 2000 | Immunology Letters2000，72，3： | 1 |
| 12 | Immune suppression of haematopoiesis in aplastic anemia activity of T lymphocytes显示文摘 | Bacigalupo A Polesta M Mingari MC | 1980 | J Immunol1980，125，： | 1 |
| 13 | Expression of HLA blass I-specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function显示文摘 | Mingari MC Porlte M Bellomo R | 2000 | Human Immunology2000，61，1： | 1 |
| 14 | Differential diappearance of inhibitory natural killer cell receptors during HAART and possible impairment of HIV-1-specific CD8 cytotoxic T lymphocytes 显示文摘 | Costa P Rusconi S Mingari MC | 2001 | AIDS2001，15，8： | 1 |
| 15 | What is a natural killer cell显示文摘 | Moretta A Bottino C Mingari MC | 2002 | Nat Immunol2002，3，： | 1 |
| 16 | Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes显示文摘 | Rolando M Barabino S Mingari C | | 0，，8： | 1 |
| 17 | Human natural killer cells: origin, clonality, specificity, and receptors显示文摘 | Moretta L Ciccone E Mingari MC | 1994 | Adv Immunol1994，55，： | 1 |
| 18 | Regulation of KIR expression in human T cells:a safety mechanism that may impair protective Tcell response显示文摘 | Mingari MC Moretta A Moretta L | 1998 | Immunol Today1998，19，4： | 1 |
| 19 | What is a natural killer cell? 显示文摘 | Moretta A Bottino C Mingari MC | 2002 | Nat Immunol2002，3，1： | 1 |
| 20 | Natural killer cells in hu- man an preguancy显示文摘 | Vacca P Mingari MC Moretta L | 2013 | J Reprod Immunol2013，97，1： | 1 |
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