|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ganoderma Lucidum polysaccharide peptides protect kidney from renal ischemia reperfusion injury via counteracting oxidative stress显示文摘OBJECTIVE Ganoderma lucidum polysaccharide peptides(GLPP)have an anti-oxidant activity.The oxidative stress implicates in the pathogenesis of renal ischemia-reperfusion injury(RIRI).The objective of this study was to determine whether GLPP could attenuate RIRI via counteracting the oxidative stress.METHODS Mice subjected to uninephrectomy with the right kidney ischemia for 35 min and reperfusion for 24 hwere used to explore the protective activity of GLPP against RIRI.In GLPP-treated group,100mg·kg-1·d-1 of GLPP were intraperitoneally injected for 7dbefore the procedure.In vitro,NRK-52 Ecells subjected to hypoxia-reoxygenation(H/R)and tunicamycin were used to explore the protective effect of GLPP against oxidative stress.The mechanisms in which GLPP protected kidney from RIRI were studied using a series of physiological and molecular biological methods.RESULTS Kidneys undergone ischemia-reperfusion showed renal dysfunction and characteristic morphological changes including cellular necrosis,brush border loss,cast formation,vacuolization and tubular dilatation while these damages were significantly attenuated by GLPP treatment.The abnormal levels of MPO,MDA and SOD caused by renal ischemia-reperfusion were significantly reversed by GLPP treatment.More apoptotic cells were found in the renal ischemia-reperfusion group than the sham group whereas GLPP reduced apoptotic cells in the ischemia-reperfusion mice by21.75%(P<0.01).The GLPPs(25-1μg·mL)alleviated H/R induced cell viability loss by 20.12%(P<0.01)andΔφm dissipation by 27.3%(P<0.01)in vitro as well and its pretreatment dramatically reduced H/R and tunicamycin induced cell injury.CONCLUSION Our study found that GLPP had a protective effect on RIRI via its anti-oxidative capacity,which suggests that GLPP may be developed as a candidate drug for preventing acute kidney injury. | Dan-danZHONG Hong-kaiWANG MingLIU Ying-liJIA MingHUANG HongZHOU Shu-qianLIN Zhi-binLIN Bao-xueYANG | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 21 |
| 2 | Prognostic value of programmed death.1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1.4N+M0 gastric adenocarcinoma显示文摘Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies. | Yuan Gao Su Li Dazhi Xu Shangxiang Chen Yuchen Cai Wenqi Jiang Xinke Zhang Jin Sun Kefeng Wang Boyang Chang Fenghua Wang Minghuang Hong | 2017 | Chinese Journal of Cancer2017，36，11： | 8 |
| 3 | Natural course of nonalcoholic fatty liver disease in southern China: A prospective cohort study显示文摘 | Yong JianZHOU Yu YuanLI Yu QiangNIE Chun MingHUANG Chuang YuCAO | 2012 | Journal of Digestive Diseases2012，，3： | 2 |
| 4 | Neutronics Performance Evaluation of Fast-Fission Fuel Breeding Blankets for a Fusion-Fission Hybrid Reactor显示文摘 | WANG Minghuang JIANG Jieqiong LIU Jinchao | 2009 | 9th International Symposium on Fusion Nuclear Technology Dalian China Fusion Engineering and Design2009，2009，： | 1 |
| 5 | Fabrication of muhiple electrodes and their application for micro-holes array in ECM 显示文摘 | Wang Minghuang Zhu Di | 2009 | Int J Adv Manuf Technol2009，41，： | 1 |
| 6 | A review of published wetland research, 1991 -2008: ecological engineering and ecosystem restoration 显示文摘 | Zhang Liang Wang Minghuang Hu Jie | 2010 | Ecological Engineering2010，36，： | 1 |
| 7 | A Fusion-driven subcritical system concept based on viable technologies 显示文摘 | WU Yican JIANG Jieqiong WANG Minghuang | 2011 | Nuclear Fusion2011，51，10： | 1 |
| 8 | Investigation on tunneling in optoelectronic devices with consideration of subwaves显示文摘Since novel optoelectronic devices based on the peculiar behaviors of the tunneling probability, e.g., resonant tunneling devices (RTD) and band-pass filter, are steadily proposed, the analytic transfer matrix (ATM) method is extended to study these devices. For several examples, we explore the effect of the scattered subwaves on tunneling; it is shown that the resonant or band-pass structures in tunneling probability are determined by the phase shift results from the scattered subwaves. | WANG XianPing YIN Cheng SANG MingHuang DAI ManYuan CAO ZhuangQi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 1 |
| 9 | Influence of heat on protein degradation, ultrastructure and eating quality indicators of pork显示文摘 | FengHuang MingHuang XinglianXu GuanghongZhou | 2011 | Food Agric2011，，3： | 1 |
| 10 | Controlled Teleportation of an Arbitrary Three-qubit State by Using Two Four-qubit Entangled States显示文摘 | SANG Minghuang DAI Hailang | 2014 | International Journal of Theoretical Physics2014，53，6： | 1 |
| 11 | Mental accounting, loss aversion, and individual stock returns 显示文摘 | BARBERIS NICHOLAS MINGHUANG | 2001 | forthcoming in Journal of Finance2001，56，： | 1 |
| 12 | Ecological restoration of mine degraded soils,with emphasis on metal contaminated soils显示文摘 | Wong Minghuang | 2003 | Chemosphere2003，50，： | 1 |
| 13 | Secure Authentication Mechanism for RFID Tag in WLAN Convergence3G Networks显示文摘 | Guo Minghuang Liaw H T Chen J F | 2012 | Security and Communication Networks2012，5，3： | 1 |
| 14 | PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation显示文摘 | Saijie Zhu Minghuang Hong Lihong Zhang Guotao Tang Yanyan Jiang Yuanying Pei | 2010 | Pharmaceutical Research2010，，： | 1 |
| 15 | A new method for measuring a small displacement by using the critical angle method and confoeal technology 显示文摘 | Liao Shujen Wang Shinn Fwu Chiu Minghuang | 2005 | SPIE2005，5635，： | 1 |
| 16 | Deter-mination of trace glyphosate in water with a prism couplin*goptical waveguide configuration 显示文摘 | Dai Hailang Sang Minghuang Wang Yuxing | 2014 | Sensors & ActuatorsA Physical2014，218，10： | 1 |
| 17 | High MW hyaluronan inhibits smoke inhalation‐induced lung injury and improves survival显示文摘 | Pei‐mingHUANG OlgaSYRKINA LunyinYU RejmonDEDAJ HangZHAO AvivaSHIEDLIN Yung‐yangLIU HariGARG Deborah A.QUINN Charles A.HALES | 2010 | Respirology2010，，7： | 1 |
| 18 | Morphology control of SAPO-34 by microwave synthesis and their performance in the methanol to olefins reaction显示文摘 | Wu Lei Liu Ziyu Qiu Minghuang | 2014 | Reaction Kinetics Mechanisms and Catalysis2014，111，1： | 1 |
| 19 | High-impact papers published in journals listed in the field of chemical engineering 显示文摘 | CHUANG Kunyang WANG Minghuang HU Yuh- shan | 2013 | Malaysian Journal of Library & Information Science2013，18，2： | 1 |
| 20 | Electrochemical copolymerization of aniline and 2, 2-dithiodianiline 显示文摘 | Li Minghuang Wen Ten-Chin Yang Chien-Hsin | 2002 | Mater Chem Phys2002，77，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员