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| 1 | Hiding digital watermarks using multiresolution wavelet transform显示文摘 | Hsieh Mingshing Tseng Dinchang | 2001 | IEEE Transactions on Industrial Electronics2001，48，： | 1 |
| 2 | Recent advances in applications of liquid chromatography-tandem mass spectrometry to the analysis of reactive drug metabolites显示文摘 | Shuguang Ma Mingshe Zhu | 2009 | Chemico-Biological Interactions2009，179，： | 1 |
| 3 | Fluidized-bed combustion of coal with lime additives: Catalytic sulfation of lime with iron compounds and coal ash显示文摘 | Yang R T Shen Mingshing Steinberg Meyer | 1978 | Environ Sci & Tech1978，12，8： | 1 |
| 4 | Adsorption of CO2 on molecular sieves and activated carbon显示文摘 | Ranjani V S Mingshing S Edward P F | 2001 | Energy & Fuels2001，，15： | 1 |
| 5 | Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome显示文摘 | Huiying Zhang Minli Lv Zhongfu Zhao Jiantao Jia Lili Zhang Peng Xiao Limin Wang Chen Li Jingquan Ji Xiaoxia Tian Xujiong Li Yimin Fan Lina Lai Yan Liu Baohong Li Cuiying Zhang Mingshe Liu Jianhong Guo Dewu Han Cheng Ji | 2014 | Gene2014，，1： | 1 |
| 6 | A novel application of the S-transform in removing powerline interference from biomedical signals显示文摘 | Huang Chienchun Liang Shengfu Young Mingshing | 2009 | Physiological Measurement2009，30，1： | 1 |
| 7 | Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome显示文摘 | Huiying Zhang Minli Lv Zhongfu Zhao Jiantao Jia Lili Zhang Peng Xiao Limin Wang Chen Li Jingquan Ji Xiaoxia Tian Xujiong Li Yimin Fan Lina Lai Yan Liu Baohong Li Cuiying Zhang Mingshe Liu Jianhong Guo Dewu Han Cheng Ji | 2014 | Gene2014，，1： | 1 |
| 8 | Plane-wave bhielding characteristics of anisotropic laminated composites显示文摘 | Lin Mingshing Chen Chunhsing | 1993 | IEEE Transactions on EMC1993，35，1： | 1 |
| 9 | Preface for special issue on new analytical techniques and methods in drug metabolism and pharmacokinetics显示文摘Analytical technologies and approaches for drug metabolism and pharmacokinetics(DMPK)research in the pharmaceutical industry and academic research institutes have evolved rapidly over the past decade.On one hand,the discovery and development of small molecule drug candidates requires earlier and better understanding of their absorption,distribution,metabolism and excretion(ADME)in human as well as their interactions with metabolizing enzymes. | Guangbo Ge Mingshe Zhu | 2020 | Journal of Pharmaceutical Analysis2020，10，3： | 0 |
| 10 | Software-aided detection and structural characterization of cyclic peptide metabolites in biological matrix by high-resolution mass spectrometry显示文摘Compared to their linear counterparts,cyclic peptides show better biological activities,such as antibacterial,immunosuppressive,and anti-tumor activities,and pharmaceutical properties due to their conformational rigidity.However,cyclic peptides could form numerous putative metabolites from potential hydrolytic cleavages and their fragments are very difficult to interpret.These characteristics pose a great challenge when analyzing metabolites of cyclic peptides by mass spectrometry.This study was to assess and apply a software-aided analytical workflow for the detection and structural characterization of cyclic peptide metabolites.Insulin and atrial natriuretic peptide(ANP)as model cyclic peptides were incubated with trypsin/chymotrypsin and/or rat liver S9,followed by data acquisition using TripleTOF?5600.Resultant full-scan MS and MS/MS datasets were automatically processed through a combination of targeted and untargeted peak finding strategies.MS/MS spectra of predicted metabolites were interrogated against putative metabolite sequences,in light of a,b,y and internal fragment series.The resulting fragment assignments led to the confirmation and ranking of the metabolite sequences and identification of metabolic modification.As a result,29 metabolites with linear or cyclic structures were detected in the insulin incubation with the hydrolytic enzymes.Sequences of twenty insulin metabolites were further determined,which were consistent with the hydrolytic sites of these enzymes.In the same manner,multiple metabolites of insulin and ANP formed in rat liver S9 incubation were detected and structurally characterized,some of which have not been previously reported.The results demonstrated the utility of software-aided data processing tool in detection and identification of cyclic peptide metabolites. | Ming Yao Tingting Cai Eva Duchoslav Li Ma Xu Guo Mingshe Zhu | 2020 | Journal of Pharmaceutical Analysis2020，10，3： | 0 |
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