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| 1 | Occurrence of emerging flame retardants from e-waste recycling activities in the northern part of Vietnam显示文摘This study investigated the contamination status of 21 emerging flame retardants(FRs)in soils(n=32)and river sediments(n=8)from an e-waste recycling(EWR)site in the northern part of Vietnam.Among analyzed FRs,higher levels of decabromodiphenyl ethane(DBDPE)(NDe4200 ng/g dw),1,2-bis-(2,4,6-tribromophenoxy)ethane(BTBPE)(NDe350 ng/g dw)and Dechlorane Plus isomers(DPs)(NDe65 ng/g dw)were found in soils near EWR workshops and open burning places.The highest concentrations of DBDPE(20 ng/g dw),BTBPE(5.7 ng/g dw)and DPs(6.7 ng/g dw)were also detected in sediments collected from the middle of the EWR site.The levels decreased concomitantly with increasing distance from the EWR site.These results indicate that these FRs were released to the surrounding environment from improper recycling activities,such as manual dismantling of devices and open burning of e-wastes.Moreover,the estimated daily intakes of those FRs via soil ingestion were approximately ten times higher for children than adults.To our knowledge,this is a first comprehensive study on characterization of soil and sediment contamination by a series of emerging FRs at an EWR site in Vietnam. | Masayuki Someya Go Suzuki Alin C.Ionas Nguyen Minh Tue Fuchao Xu Hidenori Matsukami Adrian Covaci Le Huu Tuyen Pham Hung Viet Shin Takahashi Shinsuke Tanabe Hidetaka Takigami | 2016 | Emerging Contaminants2016，2，2： | 5 |
| 2 | Analysis of monomeric and oligomeric organophosphorus flame retardants in fish muscle tissues using liquid chromatographyeelectrospray ionization tandem mass spectrometry:Application to Nile tilapia(Oreochromis niloticus)from an e-waste processing area in northern Vietnam显示文摘Using electrospray ionization tandem mass spectrometry combined with liquid chromatography(LC),a novel analytical method was developed to quantify eight monomeric organophosphorus flame retardants(m-PFRs)and three oligomeric organophosphorus flame retardants(o-PFRs)in fish muscle samples.The optimization and validation experiments indicate that the developed method can determine accurately the concentrations of analytes in fish muscle samples.The recoveries of analytes in fish muscle samples were in the range of 74-105%.The coefficients of variation of the concentrations of analytes in fish muscle samples were 0.6-8.9%.The concentrations of analytes in procedural blanks were below the limit of quantification(LOQ)values.Furthermore,the developed method was applied to the analysis of m-PFRs and o-PFRs in the muscle samples of tilapias collected from an electronic waste(ewaste)processing area in northern Vietnam.The concentrations of m-PFRs such as tris(2-chloroethyl)phosphate(TCEP),tris(2-chloroisopropyl)phosphate(TCIPP),and triphenyl phosphate(TPHP)were dominant among the investigated m-PFRs.The respective concentrations of TCEP,TCIPP,and TPHP were up to 160,300,and 230 ng g^-1 lipid weight,respectively,whereas those of o-PFRs were up to 10 ng g^-1 lipid weight.The results of this study indicate lower accumulation potential of o-PFRs compared with m-PFRs for the first time. | Hidenori Matsukami Go Suzuki Nguyen Minh Tue Le Huu Tuyen Pham Hung Viet Shin Takahashi Shinsuke Tanabe Hidetaka Takigami | 2016 | Emerging Contaminants2016，2，2： | 5 |
| 3 | Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells显示文摘Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer cells.These nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to infrared.In this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical application.After synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic acid.Folic acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via endocytosis.The sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 nm.Phase structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal system.The photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were measured.These nanophosphors emit in red color with the strongest band at 650 nm under 980 nm excitation.This result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine. | Ha Thi Phuong Tran Thu Huong Le Thi Vinh Hoang Thi Khuyen Do Thi Thao Nguyen Thanh Huong Pham Thi Lien Le Quoc Minh | 2019 | Journal of Rare Earths2019，37，11： | 5 |
| 4 | 基于隧道爆破设计模型的光面爆破参数显示文摘光面爆破效果高度依赖炮孔直径、岩石普氏系数、隧道断面和裂隙与隧道轮廓之间的间距等初始爆破参数。本文提出一种能够实现Delphi程序语言与AutoCAD对接的算法,基于提出的算法开发了一种隧道爆破设计模型。该隧道爆破设计模型能够实现以AutoCAD为平台的隧道光面爆破自动设计。在炮孔直径和隧道断面变化的条件下,研究了岩石普氏系数和裂隙间距对炮孔数量和单位炸药消耗量的影响,给出了一组高度相关方程。研究结果表明,单位炸药消耗量随着岩石普氏系数、裂隙间距和炮孔直径的增加而增加,但是随着隧道断面积的增加而减小。此外,炮孔数量随着隧道断面积的增加呈线性增加,但是随着炮孔直径的增大而减小。 | Nguyen Ngoc MINH 曹平 刘智振 | 2021 | Journal of Central South University2021，28，1： | 5 |
| 5 | 咖啡中丙烯酰胺检测方法及含量研究进展显示文摘由于丙烯酰胺对人体有神经毒性和潜在的致癌性,在美国,咖啡烘焙、咖啡粉末和速溶咖啡中丙烯酰胺都有限量。目前测定咖啡中丙烯酰胺的方法较多,每种方法各有利弊。主要介绍测定咖啡中丙烯酰胺的4种方法:气相色谱法,高效液相色谱法,气相色谱串联质谱法和液相色谱串联质谱法。总结在各种类咖啡中丙烯酰胺含量检测方法的最新进展。 | Tran Van Cuong 郭康权 鲁海霞 Nguyen Minh Phuong | 2016 | 食品研究与开发2016，37，7： | 5 |
| 6 | A sand production prediction model for weak sandstone reservoir in Kazakhstan显示文摘Weakly consolidated reservoirs are prone to sand production problem,which can lead to equipment damages and environmental issues.The conditions for sand production depend on stresses and properties of rock and fluid.Accurate sand volume estimation is,however,still a challenging issue,especially for reservoirs in weak formations.The weak reservoirs containing viscous or heavy oil are mainly discovered in shallow depths in Kazakhstan,with moderate temperature and pressure.Many prediction models developed for open-hole completions where the reservoir materials usually possess certain strength are not applicable for the local reservoirs where the materials are significantly weaker even if casing is used to support the wellbore with oil produced through the perforation tunnels.In this context,a prediction model was proposed where the volume of the produced sand was estimated as the volume of the plastic zone of the failed materials surrounding the perforation tunnels.The model assumes an evolving truncated conical shape for the damage zone and takes into account stress distributions and shear failure in this zone.Then,the proposed model was used to estimate sand volumes in 20 wells during oil production with sequential increase of flow rates.The predictions match well with the measured sand volumes in a local oil field.Finally,a sensitivity analysis was conducted on the model performance.It shows that the permeability of the plastic zone was the most significant controlling factor in the prediction results. | Ainash Shabdirova Nguyen Hop Minh Yong Zhao | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，4： | 5 |
| 7 | Genetic diversity in two threatened species in Vietnam:Taxus chinensis and Taxus wallichiana显示文摘Taxus chinensis and T. wallichiana in have been threatened in their distribution areas in recent decades because of their over-exploitation and reduction and destruction of native habitats. Determining the genetic diversity in populations of the two species will provide guidelines for their protection and preservation. Two hundred and fifteen trees from six populations of T. chinensis and150 sampled trees of T. wallichiana were sampled. Six microsatellite primer pairs selected from 16 primer pairs were used to investigate genetic variation at the population and species levels. Five yielded polymorphic alleles, and among the 13 putative alleles amplified, 11 were polymorphic(accounting for 76.33 %).Shannon's information index(I) and percentage of polymorphic bands(PPB)(I = 0.202 and PPB = 67.22 % for T. chinensis; I = 0.217 and PPB = 65.03 % for T. wallichiana). Both species had low levels of genetic diversity(mean H_o= 0.107, H_e= 0.121 for T. chinensis; H_o= 0.095, H_e= 0.109 for T. wallichiana). Genetic differentiation among populations was higher(FST= 0.189) for T. chinensis and lower(0.156) for T.wallichiana, indicating limited gene flow(Nm) among populations for T. chinensis(0.68) and T. wallichiana(0.65).Variation among individuals of T. chinensis was 63.59 and73.12 % for T. wallichiana. Thus, the threatened status of the two conifers is related to a lack of genetic diversity. All populations are isolated in small forest remnants. An ex situ conservation site should be established with a new population for these species that comprises all the genetic groups for the best chance to improve their fitness under environmental stresses. | Dinh Duy Vu Thi Tuyet Xuan Bui Minh Tam Nguyen Dinh Giap Vu Minh Duc Nguyen Van Thang Bui Xiaohua Huang Yi Zhang | 2017 | Journal of Forestry Research2017，28，2： | 4 |
| 8 | Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharide-induced acute liver injury in mice显示文摘Objective: To investigated the protective potential of ethanol extracts of Scutellaria baicalensis(S. baicalensis) against lipopolysaccharide(LPS)-induced liver injury. Methods: Dried roots of S. baicalensis were extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS(5 mg/kg of body weight, intraperitoneal injection). Both protein and m RNA levels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. C yclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB protein levels in liver tissues were analyzed by western blotting. Results: Liver injury induced by LPS signifi cantly increased necrosis factor alpha, interleukin-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB in liver tissues. Treatment with ethanol extracts of S. baicalensis prevented all of these observed changes associated with LPS-induced injury in liver mice.Conclusions: Our study showed that S. baicalensis is potentially protective against LPS-induced liver injury in mice. | Hai Nguyen Thanh Hue Pham Thi Minh Tuan Anh Le Huong Duong Thi Ly Tung Nguyen Huu Loi Vu Duc Thu Dang Kim Tung Bui Thanh | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，9： | 3 |
| 9 | Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata显示文摘Objective:To identify inhibitors of nitric oxide production and NF-κB activity from Chromolaena odorata(C.odorata).Methods:The compounds isolated from the aerial parts of C.odorata by bioassay-guided fractionation were investigated for their inhibitory effects on the NO production and NF-κB activity in LPS-stimulated RAW264.7 cells.Results:Six fatty acids (S)-coriolic acid(1),(S)-coriolic acid methyl ester(2),(5)-15,16-didehydrocoriolic acid(3),(S)- 15,16-didehydrocoriolic acid methyl ester(4),linoleamide(5) and linolenamide(6) were isolated. All compounds inhibited the NO production at concentrations consistent with those required for NF-κB inhibition.Compound 2 was the most active with the IC50 values of 5.22 and 5.73μM. The addition of a double bond in the fatty chain decreased the inhibitory effects while the methyl esterification increased the activities.Conclusions:The fatty acid components in C.odorata with NF-κB inhibitory activity could explain the anti-inflammation property of this plant in traditional medicine.This study could also contribute to the better use of C.odorata for human health care. | Tran Thi Hong Hanh Dan Thi Thuy Hang Chau Van Minh Nguyen Tien Dat | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 3 |
| 10 | 软木塞基碳量子点的水热合成及其生物相融荧光成像应用显示文摘以废弃酒瓶软木塞为原料,采用低成本、简单的水热方法合成碳量子点。通过TEM、FTIR、Raman、UV-Vis、PL光谱对碳量子点的结构和光学性能进行分析表征。结果表明,碳量子点的平均直径为6.2±2.7 nm,PL激发谱和碳量子点表面的官能团有关。用硫酸奎宁作为参考,碳量子点的量子效率为1.54%。将获得的碳量子点应用在骨髓间充质干细胞的细胞生物成像上,发现用碳量子点处理后,骨髓间充质干细胞分别在320~380 nm、450~490 nm和450~490 nm范围显示绿色、黄色和红色荧光,表明了碳量子点在荧光成像领域具有潜在的应用价值。 | Quang Ngo Khoa Hieu Nguyen Ngoc Bao Vo Van Quoc Phuoc Vo Thi Ngoc Le Xuan Diem Doc Luong Quang Tri Nguyen Minh Son Le Vu Truong Son Le Van Thanh Ha Che Thi Cam | 2022 | 新型炭材料2022，37，3： | 3 |
| 11 | Protective effect of Tetracera scandens L.leaf extract against CCl_4-induced acute liver injury in rats显示文摘Objective:To investigate the protective potential of ethanolic extracts of Tetracera scandens L.(T.scandens) against CCl_4 induced oxidative stress in liver tissues.Methods:Dried leaf powder of T.scandens was extracted with ethanol and concentrated to yield a dry residue.Rats were administered with 100 mg/kg of ethanolic extracts orally once daily for one week.Animals were subsequently administered with a single dose of CCl_4(I mL/kg body weight,intraperitoneal injection).Various assays,such as serum levels of alanine aminotransferase,aspartate aminotransferase,lipid peroxidation,protein oxidation(carbonyl protein group),tumor necrosis factor alpha,catalase,superoxide dismutase,and glutathione peroxidase,were used to assess damage caused by CCl_4 and the protective effects of the ethanol extract on liver tissues.Results:Hepatotoxicity induced by CCl_4 was evidenced by a significant increase in serum aspartate aminotransferase and alanine aminotransferase level,lipid peroxidation,protein carbonyl group,and tumor necrosis factor alpha,as well as decreased activity of the hepatic antioxidant enzymes(catalase.superoxide dismutase.and glutathione peroxidase).Treatment with ethanolic T.scandens extracts prevented all of these typically observed changes in CCl_4-treated rats.Conclusions:Our findings indicate that T.scandens has a significant protective effect against CCl_4 induced hepatotoxicity in rat.which may be due to its antioxidant properties. | Tung Bui Thanh Hai Nguyen Thanh Hue Pham Thi Minh Huong Le-Thi-Thu Huong Duong Thi Ly Loi Vu Duc | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，3： | 3 |
| 12 | 基于RFID技术的多通道信息识别机设计与实现显示文摘为研究贴有电子标签的货物在信息识别过程中由不同的方向进入射频识别通道机以提高货物识别效率,对多通道射频识别通道机内的天线系统、自动屏蔽门系统、输送系统进行性能试验研究.通过分析天线系统的识别角度和范围,设计自动屏蔽门系统的电机,布局光电开关,测试输送系统速率和选择电滚筒材料等,运用Tecnomatix Plant Simulation 9仿真软件对通道机各组成的结构及不同的工况进行仿真测试,仿真结果验证了多通道机在相同的工况下比单通道机性能优越.研究表明:本多通道信息识别机对多通道设计合理,各系统参数满足物联网工程应用中射频识别(RFID)信息识别的效率要求. | 李京文 胡涵清 王江 NGUYEN Quang Minh 申思磊 赵冰心 | 2014 | 北京工业大学学报2014，40，12： | 2 |
| 13 | Relationship between Endoscopic and Histologic Gastric Atrophy and Intestinal Metaplasia显示文摘 | Duc Trong Quach Huy Minh Le Toru Hiyama Oanh Thuy Nguyen Trung Sao Nguyen Naomi Uemura | 2012 | Helicobacter2012，，2： | 2 |
| 14 | Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβplaques and brain rhythms in 5×FAD mice显示文摘Background:Alzheimer's disease(AD)is the most common cause of dementia,and is characterized by amyloid-β(Aβ)plaques and tauopathy.Reducing Aβhas been considered a major AD treatment strategy in pharmacological and non-pharmacological approaches.Impairment of gamma oscillations,which play an important role in perception and cognitive function,has been shown in mouse AD models and human patients.Recently,the therapeutic effect of gamma entrainment in AD mouse models has been reported.Given that ultrasound is an emerging neuromodulation modality,we investigated the effect of ultrasound stimulation pulsed at gamma frequency(40 Hz)in an AD mouse model.Methods:We implanted electroencephalogram(EEG)electrodes and a piezo-ceramic disc ultrasound transducer on the skull surface of 6-month-old 5×FAD and wild-type control mice(n=12 and 6,respectively).Six 5×FAD mice were treated with two-hour ultrasound stimulation at 40 Hz daily for two weeks,and the other six mice received sham treatment.Soluble and insoluble Aβlevels in the brain were measured by enzyme-linked immunosorbent assay.Spontaneous EEG gamma power was computed by wavelet analysis,and the brain connectivity was examined with phase-locking value and cross-frequency phase-amplitude coupling.Results:We found that the total Aβ42 levels,especially insoluble Aβ42;in the treatment group decreased in pre-and infra-limbic cortex(PIL)compared to that of the sham treatment group.A reduction in the number of Aβplaques was also observed in the hippocampus.There was no increase in microbleeding in the transcranial ultrasound stimulation(tUS)group.In addition,the length and number of microglial processes decreased in PIL and hippocampus.Encel-phalographic spontaneous gamma power was increased,and cross-frequency coupling was normalized,implying functional improvement after tUS stimulation.Conclusion:These results suggest that the transcranial ultrasound-based gamma-band entrainment technique can be an effective therapy for AD by reducing the Aβload and improving brain connectivity. | Mincheol Park Gia Minh Hoang Thien Nguyen Eunkyung Lee Hyun Jin Jung Youngshik Choe Moon Hwan Lee Jae Youn Hwang Jae Gwan Kim Tae Kim | 2021 | Translational Neurodegeneration2021，10，4： | 2 |
| 15 | Synthesis and characterization of core/shell structured nanophosphors CePO_4:Tb@LaPO_4 by solvothermal method显示文摘Core/shell structured CePO4:Tb(III) @LaPO4 and CePO4:Tb(III) were successfully synthesized in tris(2-ethylhexyl) phosphate(TEHP) and diethylene glycol(DEG) solvents for comparison of the two techniques in open air and closed reaction vessel.Morphology and crystal structure of the core/shell nanophosphors were determined by using X-ray diffraction(XRD) and transmission electron microscopy(TEM) ,which showed that nanophosphors had diameter of about 5-10 nm with the monoclinic monazite phase.The nanophosphors obtained by close vessel procedure showed smaller size,more homogeneity and pure crystallite.The luminescent measurements were done upon the different excitation wavelengths in ultraviolet region and at room temperature to elucidate the influences of the used solvents and the reaction temperatures.It was found that CePO4:Tb@LaPO4 prepared by the close vessel synthesis showed the intensity of green band of the transfer from 5D4 to 7F5 energy level,which was strongly increased,and the luminescent decay time was 3.2 ms,which was longer than that of naked CePO4:Tb phosphor. | Dinh Xuan Loc Tran Thi Kim Chi Tran Thu Huong Nguyen Vu Tran Kim Anh Wieslaw Strek Le Quoc Minh | 2011 | Journal of Rare Earths2011，29，12： | 2 |
| 16 | Synthesis of cation exchange resin-supported iron and magnesium oxides/hydroxides composite for nitrate removal in water显示文摘In this study,we reported on the concept and practical use of cation exchange resin(CER)for removing anions in water via pretreating the CER with metal salts.The cation exchange resinsupported iron and magnesium oxides/hydroxides composite(FeMg/CER)was synthesized and introduced as a new and potential adsorbent for selective removal of nitrate ion in the water environment.Characteristics of FeMg/CER were determined by techniques such as Fouriertransform infrared spectroscopy,scanning electron microscopy,and Xray diffraction.The results showed that FeMg/CER material had a high nitrate adsorption capacity of 200 mg NO_(3)^()·g^(1)with a fast equilibrium adsorption time of 30 min at pH 5.In addition,it had good durability of at least 10 times of regeneration,which could be applied to practical water and wastewater treatment. | Trung Thanh Nguyen Vu Anh Khoa Tran Le Ba Tran Phuoc Toan Phan Minh Tan Nguyen Long Giang Bach Surapol Padungthon Cong Khiem Ta Nhat Huy Nguyen | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 2 |
| 17 | Structural and luminescent properties of (Eu,Tb) PO_4·H_2O nanorods/nanowires prepared by microwave technique显示文摘Nanowires/nanorods of europium/terbium orthophosphate monohydrate with Eu3+ concentration of 6,11,and 20 at.% were prepared by microwave synthesis method.The effects of Eu3+ doping concentration on structure,morphology and optical properties of nanoma-terials were also investigated.The results showed that,for all studied Eu3+ doping concentrations,a single-crystalline phase of rhabdo-phane-type(Eu,Tb) PO4·H2O nanowires/nanorods was obtained by using microwave heating of an aqueous solution of terbium(III) nitrate,europium(III) nitrate and NH4H2PO4 with pH=2.The length and width of these nanowires/nanorods ranged from 150 to 300 nm and from 10 to 50 nm,respectively.The evidence of energy transfer from Tb3+ to Eu3+ due to the energy overlap between the donor Tb3+ and the acceptor Eu3+ was observed obviously via a significant enhancement in the luminescent intensity of Eu3+. | Nguyen Thanh Huong Nguyen Duc Van Dinh Manh Tien Do Khanh Tung Nguyen Thanh Binh Tran Kim Anh Le Quoc Minh | 2011 | Journal of Rare Earths2011，29，12： | 2 |
| 18 | Effectiveness on post-stroke hemiplegia in patients:electroacupuncture plus cycling vs electroacupuncture alone显示文摘OBJECTIVE:To evaluate the effectiveness of cycling in combination with electroacupuncture in treatment of poststroke hemiplegia patients at National Hospital of Acupuncture,Vietnam.METHODS:The study was designed as a single-centre,outcome-assessor-blinded parallel randomised controlled trial with 120 post-stroke hemiplegia patients randomly assigned into two groups:electroacupuncture plus cycling(CT group) and electroacupuncture(AT group).Patients were assessed before and after the treatment(using muscle grading,modified Rankin,Barthel,Orgorozo scores and electromyography).Statistical Man–Whitney U test,and Fisher’s exact tests were used to compare between CT and AT groups.RESULTS:The results reported statistically significant improvement in motor function in patients suffering from hemiplegia following ischemic stroke in both CT and AT groups.Patients in CT group experienced a greater improvement compared to those in AT group including better muscle contraction(increased frequency and amplitude of electromyography and increased muscle grading scale);increased recovery(Orgogozo scale),increased independency(Barthel scale) and decreased disability(Modified Rankin scale)(P < 0.01).CONCLUSIONS:Combination with cycling training significantly improves the recovery of post-stroke patients treated with electroacupuncture. | Minh Duc Nguyen Thanh Van Tran Quoc Vinh Nguyen Ninh Khac Nguyen Son Truong Vu Luu Trong Nguyen Linh Vu Phuong Dang | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 2 |
| 19 | 骨形态发生蛋白15基因多态性与复发性葡萄胎和习惯性流产的相关性研究显示文摘目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显子测序分析患者BMP15基因的多态性,并采用蛋白功能预测软件预测各SNPs对BMP15蛋白功能的影响。结果在BMP15基因2个外显子中共检测到5个错义突变和1个插入突变。其中在外显子1中检测到2个错义突变(p.S5R和p.N103S);在外显子2中检测到3个错义突变(p.L148P,p.A180T,p.H200Y)和1个插入突变,(p.Leu263dup)。通过预测,p.L148P突变可能会严重影响BMP15蛋白的活性进而影响卵巢功能,而p.S5R突变的影响相对较小,其余SNPs对BMP15蛋白功能基本无影响。结论 BMP15基因突变除了可能与RHMs和习惯性流产妇女的卵泡生成障碍及卵巢功能早衰相关,还可能导致葡萄胎恶变。 | 王鹤 Ramesh Reddy Ngoc Minh Phuong Nguyen Seang L Tan Rima Slim | 2017 | 中国妇幼保健2017，32，11： | 2 |
| 20 | 刘凤斌教授治疗溃疡性结肠炎经验显示文摘介绍刘凤斌教授治疗溃疡性结肠炎的经验,认为溃疡性结肠炎病位主要在脾与大肠,且与肝肾关系密切。病因病机可归纳为:热(湿热)、虚(脾虚、肾虚、脾肾虚)、气(气郁)、瘀(血瘀),临床上分急性期、缓解期,有热毒炽盛、大肠湿热、脾胃虚弱、脾肾不足、肝脾不调等证型。急性期治以清热祛湿为主,缓解期治以健脾渗湿为法,各阶段治疗均考虑到以脾胃为中心,五脏相关,配合疏肝、益肾之法;且气滞血瘀贯穿病程始终,可适当运用活血化瘀之法。临床辨证论治,诸法参用,且需慎饮食,调情志。 | Nguyen Thi Minh Thu Nguyen Tuan Anh 刘凤斌 | 2014 | 新中医2014，46，6： | 2 |
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