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| 1 | 肩关节镜辅助下小切口肩峰成形及肩袖修补显示文摘目的 探讨肩关节镜辅助下小切口肩袖修补手术的临床应用价值。方法 本组 2 6例患者 ,在关节镜下完成肩峰成形 ,然后在小切口内对肩袖完全破裂的 18例患者行肌腱 骨隧道缝合 ,对部分破裂的 8例患者行肌腱 肌腱缝合。结果 术后随访 2 1~ 4 8个月 (平均 37.5个月 ) ,所有患者均无术后感染及肩关节粘连发生 ,肩关节疼痛 ,特别是夜间痛明显改善 ,手术疗效满意。UCLA评分由术前平均 2 0 .1分改善至术后 31.6分。结论 本术式可确定肩关节面一侧肩袖破裂的部位及深度 ,且不破坏三角肌的连续性。手术效果好 ,患者可较早进行功能煅练 ,功能恢复快。 | 韦民 Minola Riccardo 张钟元 | 2003 | 上海医学2003，26，2： | 14 |
| 2 | Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone显示文摘Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody(mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid(LTA). Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immuno PET imaging in an in vivo mouse model of prosthetic joint infection(PJI). In vitro and ex vivo binding of the anti-LTA mAb to pathogenic bacteria was measured with Octet, ELISA, and flow cytometry. The in vivo PJI mouse model was assessed using traditional imaging modalities, including positron emission tomography(PET) with [^(18)F]FDG and [^(18)F]Na F as well as X-ray computed tomography(CT), before being evaluated with the zirconium-89-labeled antibody specific for LTA([^(89)Zr]SAC55).The anti-LTA mAb exhibited specific binding in vitro to LTA-expressing bacteria. Results from imaging showed that our model could reliably simulate infection at the surgical site by bioluminescent imaging, conventional PET tracer imaging, and bone morphological changes by CT. One day following injection of both the radiolabeled anti-LTA and isotype control antibodies, the anti-LTA antibody demonstrated significantly greater(P < 0.05) uptake at S. aureus-infected prosthesis sites over either the same antibody at sterile prosthesis sites or of control non-specific antibody at infected prosthesis sites. Taken together, the radiolabeled anti-LTA mAb, [^(89)Zr]SAC55, may serve as a valuable diagnostic molecular imaging probe to help distinguish between sterile inflammation and infection in the setting of PJI. Future studies are needed to determine whether these findings will translate to human PJI. | Julie E.Pickett John M.Thompson Agnieszka Sadowska Christine Tkaczyk Bret R.Sellman Andrea Minola Davide Corti Antonio Lanzavecchia Lloyd S.Miller Daniel LJ Thorek | 2018 | Bone Research2018，6，2： | 3 |
| 3 | Female patients in fertile age with chronic hepatitis C, easy genotype, and persistently normal transaminases have a 100% chance to reach a sustained virological response显示文摘 | Annarosa Floreani Nora Cazzagon Deris Gianni Boemo Tatjana Baldovin Vincenzo Baldo Joel Egoue Sara Antoniazzi Eliseo Minola | 2011 | European Journal of Gastroenterology & Hepatology2011，，11： | 2 |
| 4 | Diagnostic value of colour Doppler twinkling artefact in sites negative for stones on B mode renal sonography 显示文摘 | Turrin A Minola P Costa F | 2007 | Urological Re- search2007，35，6： | 1 |
| 5 | Clinical course of pregnant women with chronic hepatitis C virus infection and risk of mother-to-child hepatitis C virus transmission显示文摘 | Colucci A Minola E | 2001 | Dig Liver Dis2001，33，： | 1 |
| 6 | Cryoglobulinemia显示文摘 | Tedeschi A Baratè C Minola E | 2007 | Blood Rev2007，21，： | 1 |
| 7 | Amniocentesis as a possible risk factor for mother-to-infant transmission of hepatitis C virus显示文摘 | Minola E Maccabruni A Pacati I | 2001 | Hepatology2001，33，： | 1 |
| 8 | Cryoglobulinemia显示文摘 | Tedeschi A Barat C Minola E | 2007 | Blood Rev2007，21，4： | 1 |
| 9 | Entrepreneurial learn- ing in Italian high -tech start- ups: an exploratory study 显示文摘 | Massis A D Minola T Viviani D | 2012 | International Journal of Innovation and Learning2012，，： | 1 |
| 10 | Charaeterisation of HCV genotype 2/3 patients without a rapid virological response (RVR) optimising treatment by predicting slower responders to peginterferon a2a plus ribavirin显示文摘 | Shiffman ML Minola E Barange K | 2007 | Hepatol2007，46，1： | 1 |
| 11 | Amnioeentesis as a possible risk factor for mother-to-infant transmission of hepatitis C virus显示文摘 | Minola E Maccabruni A Paeati I | 2001 | Hepatol''ogy2001，33，5： | 1 |
| 12 | Chromosomal alterations in hepatocellular nodules bycomparative genomic hybridization:high-grade dysplasticnodules represent early stages of hepatocellular carcinoma显示文摘 | Tornillo L Carafa V Sauter G Moch H Minola E GambacortaM | 2002 | Lab Invest2002，82，： | 1 |
| 13 | Histological and virological features and follow-up of hepatitis C virus carriers with normal aminotransferase levels: the Italian prospective study of the asymptomatic C carriers (ISACC)显示文摘 | Claudio Puoti Roberto Castellacci Fabrizio Montagnese Serena Zaltron Gianfranca Stornaiuolo Nicoletta Bergami Lia Bellis Davide F Precone Paolo Corvisieri Massimo Puoti Eliseo Minola Giovanni Battista Gaeta | 2002 | Journal of Hepatology2002，，1： | 1 |
| 14 | Clinical course of pregnant woman with chronic hepatitis C virus infection and risk of monther-to-child hepatitis C virus transmission 显示文摘 | Conte D Colucci A Minola E | 2001 | Dig Liver Dis2001，33，4： | 1 |
| 15 | Who's going to provide the funding for high tech start-ups?a model for the analysis of determinants with a fuzzy approach显示文摘 | MINOLA T GIORGINO M | 2008 | R&D Management2008，38，3： | 1 |
| 16 | Morphometric analysis of primary grat non-function in liver transplantation显示文摘 | Vertemati M Sabatella G Minola E | 2005 | Histopathology2005，46，： | 1 |
| 17 | Gene expression, cytoskeletalchanges and extracellular matrix synthesis in human osteoblaststreated with cyclosporin A显示文摘 | Vertemati M Minola E Dolci C | 2009 | Biomed Pharmacother2009，63，9： | 1 |
| 18 | Diagnostic value of eolour Doppler twinkling artefact in sites negative for stones on B mode renal sonograghy显示文摘 | Turrin A Minola P Costa F | 2007 | Urol Res2007，35，： | 1 |
| 19 | Who's going to provide the funding for high tech start-ups? A model for the analysis of determinants with a fuzzy approach显示文摘 | Minola T Giorgino M | 2008 | R & amp DManagement2008，38，3： | 1 |
| 20 | Shifting of summertime weather extremes in Western Europe during 2012-2020显示文摘Over the past decades,droughts and heatwaves frequently appeared in Western Europe(45°-65°N,10°W-20°E)during boreal summer,causing huge impacts on human society and ecosystems.Although these extremes are projected to increase in both frequency and intensity under a warming climate,our knowledge of their interdecadal variations and causes is relatively limited.Here we show that the droughts and heatwaves in Western Europe have shifted in their trends in the last decade:for 1979-2012,wind speed and precipitation have both strengthened in Western Europe;for 2012-2020,however,Western Europe have experienced declined wind speed,decreased precipitation,and higher air temperature,leading to more frequent droughts and heatwaves there.Recent changes in the WE climate and extremes are related to the variations of the North Atlantic westerly jet stream.In 1979-2012(2012-2020),the westerly jet stream shifted equatorward(poleward),which enhanced(reduced)transportation of water vapor fluxes from the North Atlantic Ocean to the European land areas,resulting in wetter(drier)surface in Western Europe.Further analysis suggests that phase changes in the Pacific Decadal Oscillation could have played a key role in regulating the position of the jet stream,providing important implications for decadal predictions of the Western Europe summertime climate and weather extremes. | Kai-Qiang DENG Cesar AZORIN-MOLINA Song YANG Chun-Di HU Gang-Feng ZHANG Lorenzo MINOLA Sergio VICENTE-SERRANO Deliang CHEN | 2022 | Advances in Climate Change Research2022，13，2： | 0 |
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