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| 1 | Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice显示文摘Mecobalamin,a form of vitamin B12 containing a central metal element(cobalt),is one of the most important mediators of nervous system function.In the clinic,it is often used to accelerate recovery of peripheral nerves,but its molecular mechanism remains unclear.In the present study,we performed sciatic nerve crush injury in mice,followed by daily intraperitoneal administration of mecobalamin(65 μg/kg or 130 μg/kg) or saline(negative control).Walking track analysis,histomorphological examination,and quantitative real-time PCR showed that mecobalamin significantly improved functional recovery of the sciatic nerve,thickened the myelin sheath in myelinated nerve fibers,and increased the cross-sectional area of target muscle cells.Furthermore,mecobalamin upregulated m RNA expression of growth associated protein 43 in nerve tissue ipsilateral to the injury,and of neurotrophic factors(nerve growth factor,brain-derived nerve growth factor and ciliary neurotrophic factor) in the L4–6 dorsal root ganglia.Our findings indicate that the molecular mechanism underlying the therapeutic effect of mecobalamin after sciatic nerve injury involves the upregulation of multiple neurotrophic factor genes. | Lin Gan Minquan Qian Keqin Shi Gang Chen Yanglin Gu Wei Du Guoxing Zhu | 2014 | Neural Regeneration Research2014，9，22： | 11 |
| 2 | Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms显示文摘Early childhood caries(ECC)is a public healthcare concern that greatly reduces the quality of life of young children.As a leading factor of ECC,cariogenic biofilms are composed of acidogenic/aciduric pathogens and extracellular polysaccharides(EPSs),creating an acidic and protected microenvironment.Antimicrobial photodynamic therapy(aPDT)is a noninvasive,painless,and efficient therapeutic approach that is suitable for treating ECC.However,due to the hyperfine structure of cariogenic biofilms,most photosensitizers(PSs)could not access and penetrate deeply in biofilms,which dramatically hamper their efficiency in the clinic.Herein,bioresponsive nanoparticle loaded with chlorin e6(MPP-Ce6)is developed,which largely increases the penetration depth(by over 75%)and retention(by over 100%)of PS in the biofilm compared with free Ce6.Furthermore,MPP-Ce6-mediated aPDT not only kills the bacteria in preformed biofilms but also inhibits multispecies biofilm formation.A rampant caries model is established to mimic ECC in vivo,where the population of cariogenic bacteria is decreased to 10%after MPP-Ce6-mediated aPDT.Importantly,the number and severity of carious lesions are efficiently reduced via Keyes’scoring and micro-CT analysis.This simple but effective strategy can serve as a promising approach for daily oral hygiene in preventing ECC. | Danfeng Liu Xianbin Ma Yaoting Ji Rourong Chen Shuhui Zhou Hantao Yao Zichen Zhang Mengjie Ye Zhigang Xu Minquan Du | 2022 | Bioactive Materials2022，7，8： | 2 |
| 3 | In vitro activity of eugenol against Candida albicans biofilms 显示文摘 | Miao He Minquan Du Mingwen Fan | 2007 | Mycopathologia2007，163，3： | 1 |
| 4 | In vitro activity of eugenol against Candida albicans biofilms 显示文摘 | Miao He Minquan Du Mingwen Fan | 2007 | Mycopathologia2007，163，3： | 1 |
| 5 | In vitro activity of eugenol against Candida albicans biofilms显示文摘 | Miao He Minquan Du Mingwen Fan Zhuan Bian | 2007 | Mycopathologia2007，，3： | 1 |
| 6 | Randomized controlled trial on fluoride varnish application for treatment of white spot lesion after fixed orthodontic treatment显示文摘 | Minquan Du Ning Cheng Baojun Tai Han Jiang Jing Li Zhuan Bian | 2012 | Clinical Oral Investigations2012，，2： | 1 |
| 7 | Randomized controlled trial on fluoride varnish application for treatment of white spot lesion after fixed orthodontic treatment 显示文摘 | Minquan Du Ning Cheng Baojun Tai | 2012 | Clin Oral Investig2012，16，2： | 1 |
| 8 | STUDIES ON UNIFORM VELOCITY DISTRIBUTION IN CYLINDRICAL VESSELS WITH ANNULAR PACKED-BED显示文摘The uniform distribution of radial velocities of flow is of great importance for a cylindrical vessel with annular packed-bed (CVAPB). In this paper, a theoretical analysis for producing a uniform radial velocity distribution within a vessel is presented and a design method is established for a specially designed conical chock (SDCC). A differential equation for determining the contour size of SDCC is derived. Experimental verification is performed in a test model of CVAPB. The results show that the axial distribution of differential pressures across the packed-bed become uniform for CVAPB with SDCC and the uniformity of radial velocity is improved. | Wu, Minquan Huang, Farui Du, Pin Shu, Zhongming | 1997 | Journal of Hydrodynamics1997，9，2： | 0 |
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