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| 1 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 2 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 3 | Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents 显示文摘 | BANDAY A H MIR B P LONE I H | 2010 | Steroids2010，75，12： | 1 |
| 4 | Tissue ablation with irreversible eleetroporation显示文摘 | Davalos R V Mir L M Rubinsky B | 2005 | Annals of Biomedical Engineering2005，33，2： | 1 |
| 5 | Management of unstable thoracolumbar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 6 | Management of unstablethoracolum-bar spinal injuries by posterior short segmentspinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 7 | Drug-induced effects on erlotinih metabo显示文摘 | Mir O Blanchet B Goldwasser F | 2011 | N Engl J Med2011，365，4： | 1 |
| 8 | Tissue ablation with irreversible electroporation显示文摘 | Davalos RV Mir IL Rubinsky B | 2005 | Ann Biomed Eng2005，33，2： | 1 |
| 9 | Preparation and characterization of n-type conductive (A1, Co) co-doped ZnO thin films deposited by sputtering from aerogel nanopowders 显示文摘 | Mir L E Ayadi Z B Saadoun M | 2007 | Appl Surf Sci2007，254，： | 1 |
| 10 | Management of unstable thoracolum-bar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | IntOrthop2007，31，2： | 1 |
| 11 | Chemopreventive and therapeutic potential of'naringenin,'a flavanone present in citrus fruits显示文摘 | I A Mir A B Tiku | 2015 | Nutrition and Cancer2015，67，1： | 1 |
| 12 | Microstruetural, structural and electrical properties of La^3+ -modified Bi4 Ti3 O12 ferroelectric ceramics显示文摘 | Santos V B M'Peko J C Mir M | 2009 | Journal of the European Ceramic Society2009，29，4： | 1 |
| 13 | Management of unsta- ble thoracolumbar spinal injuries by posterior short seg- ment spinal fixation 显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 14 | Levels of brain natriuretic peptide in children with right ventrieular overload due to congenital cardiac disease 显示文摘 | Mir TS Falkenberg J Friedrich B | 2005 | Cardiol Young2005，15，4： | 1 |
| 15 | Management of un- stable thoracolumbar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 16 | The New Age Employee: An Exploration of Changing Employee-Organization Relations 显示文摘 | Mir A Mir R Mosca J B | 2002 | Public Personnel Management2002，31，2： | 1 |
| 17 | Management of unsta- blethoraeolumbar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | IntOrthop2007，31，2： | 1 |
| 18 | Tissue ablation with irreversible electroporation显示文摘 | Davalos R V Mir I L Rubinsky B | 2005 | Annals of Biomedical Engineering2005，33，2： | 1 |
| 19 | Management of unstable thoracolum- bar spinal injuries by posterior short segment spinal fixation 显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Or- thop2007，31，2： | 1 |
| 20 | Phonon Spectra Evolution and Soft-Mode Instabilities of Ziro0nia During the c-t-m Transformarion 显示文摘 | MIR GORODSKY A P BMIRNOV M B | 1999 | Jourmal of Physics and Chemistry of Xolids1999，60，7： | 1 |
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