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| 1 | Effects of copper and zinc on the activated sludge bacteria growth kinetics显示文摘 | Cabrero A Fernandez S Mirada F | 1998 | Water Res1998，32，5： | 1 |
| 2 | Effects of copper and zinc on the activated sludge bacteria growth kinetics 显示文摘 | CABRERO A FERNANDEZ S MIRADA F | 1998 | Water Res1998，32，5： | 1 |
| 3 | Severe odontogenic infections: epidemiological, microbiological and therapeutic factors 显示文摘 | S??nchez R Mirada E Arias J | | Med Oral Patol Oral Cir Bucal0，16，5： | 1 |
| 4 | Tacalcitol in the treatment of psoriasis vulgaris: the Spanish experience显示文摘 | Lecha M Mirada A L6pez S | 2005 | J Eur Aead Dermatol Venereol2005，19，： | 1 |
| 5 | Tacalcitol in the treatment of psoriasis vulgaris: the Spanish experance 显示文摘 | Lecha M Mirada A Lopez S | 2005 | Eur Acad Dermatol2005，19，： | 1 |
| 6 | The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer's disease显示文摘 | Mirada S Opazo C Larrondo LF | 2000 | Prog Neurobiol2000，62，6： | 1 |
| 7 | Tacalcitol in the treatment of psoriasis vulgaris:the Spanish experience显示文摘 | Lecha M Mirada A Lopez S | 2005 | J Eur Aead Dermatol Venereol2005，19，8： | 1 |
| 8 | Effects of copper and zinc on the activated sludge bacteria growth kinetics显示文摘 | CABRERO A FERNANDEZ S MIRADA F | 1998 | Water Research1998，32，5： | 1 |
| 9 | A systems approach for the estmation of the effects of land consolidation projects(LCPS):a model and its application显示文摘 | Castro C J Aguiar P P Mirada S L | 2001 | Agricultural System2001，68，： | 1 |
| 10 | Severe odontogenicinfections:epidemiological,microbiological and therapeuticfactors显示文摘 | Sánchez R Mirada E Arias J | 2011 | Med Oral Patol Oral Cir Bucal2011，16，5： | 1 |
| 11 | Effects of copper and zinc on the activated sludge bacterial growth kinetics显示文摘 | Cabrero A Fernandez S Mirada F | 1998 | Water Research1998，32，： | 1 |
| 12 | Effects of copper and zinc on the activated sludge bacteria growth kinetics 显示文摘 | Cabrero A Fernandez S Mirada F | 1998 | Water Res1998，32，5： | 1 |
| 13 | 在西班牙使用他卡西醇治疗寻常型银屑病的经验显示文摘Background: A group of vitamin D derivatives has revealed to be an efficient treatment for psoriasis. Different types of studies have been designed to confirm the efficacy of its use without relevant side-effects. Objective: Evaluation of tolerability and efficacy of tacalcitol ointment in moderate psoriasis. Design: A 2-month multicentre prospective open-label observational study in patients with psoriasis treated with tacalcitol ointment. Methods: A cohort of patients with psoriasis vulgaris seeking medical advice and being treated with tacalcitol based on the decision of their dermatologists was selected. A 2-month follow- up was performed to assess efficacy and tolerability of tacalcitol in an ointmen t formulation (4 μg/g) once daily. A psoriatic lesion was selected in each pati ent in order to assess clinical symptoms (erythema, desquamation and thickness) by means of five-point scale: 0 (none) to 4 (maximal severity). Percentages of involved skin, adverse effects, physicians’global assessments of efficacy and t olerability, and patients’global satisfaction scores were also evaluated after 15-30 days (first visit) and 2 months (second visit) of treatment. Results: A t otal of 556 patients were included. Mean psoriasis duration was 10.1 years (rang e, 0-61 years). Follow-up data were available for 493 patients in first follow -up visit and 449 in second (final) visit. Adverse events were uncommon (1.0%a nd 0.6%of patients in first and second follow-up visits, respectively). At fir st follow-up visit, mean decrease in selected lesions surface area (from a base line value of 185.8 cm2 per lesion) was 11.1 cm2 (95%CI, 1.6-20.6; P=0.0213). After 2 months of treatment, mean scores for erythema, desquamation and thicknes s changed from 2.2 ±0.8 to 1.1 ±0.8 (19%of patients with no erythema at final visit); from 2.4 ±0.8 to 0.6 ±0.7 (55%of patients with no desquamation); and from 2.2 ±0.9 to 0.8 ±0.6 (51%of patients with less thickness), respectively. Mean percentage of total body skin involvement was 14%(7.5%and 6.9%of anterior and posterior body surf ace,respectively). After 2months of treatment, a 3.2%(95%CI, 2.7-3.8;P=0.0001 ) and 3.0%(95%CI, 2.4-3.6; P=0.0001) decrease was observed in the percentage of involved anterior and posterior skin surface area, respectively. Efficacy and tolerability evaluation by investigators was very good or good in 94%and 74%o f patients, respectively; 78%of patients evaluated study treatment as satisfact ory/ very satisfactory. More than 80%, 50-80% and less than 50%of prescribed doses were used by 88%, 9.3%and 2.3%of pati ents, respectively. Conclusions: Tacalcitol was highly effective in the symptoma tic treatment of moderate psoriasis. Compliance was very high, probably due to t he easy and convenient application. Physicians’global assessments of tacalcitol were excellent, both for tolerability and efficacy. Excellent tolerability was confirmed by the low rate of adverse events. Our results in an everyday clinical setting show that tacalcitol is a useful therapy in patients with moderate psor iasis. | Lecha M Mirada A López S Artés M 刘芯 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，1： | 0 |
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