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| 1 | 酞咪哌啶酮对多发性骨髓瘤细胞系血管新生抑制作用的研究显示文摘目的 研究多发性骨髓瘤 (MM)细胞系培养上清液对人骨髓来源的内皮细胞系(HBMEC)的增殖、迁移、血管新生的促进作用及酞咪哌啶酮对其抑制作用。方法 用MM细胞系 (IM9、XG1、U2 6 6和MOLP 5 )培养上清液培养HBMEC ,检测其对HBMEC的增殖、迁移作用。在纤维蛋白胶及基质胶 (matrigel)中观察此上清液对血管新生的影响 ,并研究酞咪哌啶酮对这些作用的抑制。用酶联免疫吸附实验 (ELISA)测定此上清液中血管内皮生长因子 (VEGF)含量。结果 MM培养上清液明显促进HBMEC的增殖及迁移。在纤维蛋白胶及基质胶 (matrigel)中 ,促进微血管的生长。这些作用均可被酞咪哌啶酮抑制。所有这些作用与MM细胞系产生的VEGF无相关性。结论 MM细胞系通过分泌VEGF或其他某些细胞因子促进HBMEC的增殖、迁移及微血管形成 ;酞咪哌啶酮可抑制这些作用 。 | 陈文明 朱嘉芷 F Mirshahi J Soria M Mirshahi C Soria | 2002 | 中华血液学杂志2002，23，10： | 5 |
| 2 | 多发性骨髓瘤血管新生的体外研究显示文摘探讨多发性骨髓瘤细胞系培养上清液对人骨髓来源内皮细胞系(HBMEC)的增殖、迁移及血管新生的作用。用含2%胎牛血清(FBS)的RPMI 1640培养液培养骨髓瘤细胞系获得上清液,将此培养液培养HBMEC,研究其时HBMEC的增殖及迁移的影响,并将此液放入含有携带HBMEC微珠的三维纤维蛋白中,研究其对血管新生的影响。结果表明,与含2%FBS的RPMI 1640培养液比较,骨髓瘤细胞系培养液对HBMEC的增殖有明显促进作用(P<0.001),并促进HBMEC的迁移,诱导毛细血管管腔的形成(长度及宽度)(P<0.001)。结论:骨髓瘤细胞系可能通过分泌某些细胞因子促进HBMEC增殖、迁移及血管新生。 | 陈文明 吴垠 朱嘉芷 Jeannette Soria Massoud Mirshahi | 2002 | 中国实验血液学杂志2002，10，4： | 4 |
| 3 | Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities显示文摘 | Arun J. Sanyal Carol Campbell-Sargent Faridoddin Mirshahi William B. Rizzo Melissa J. Contos Richard K. Sterling Velimir A. Luketic Mitchell L. Shiffman John N. Clore | 2001 | Gastroenterology2001，，5： | 3 |
| 4 | 7088 A lipidomic analysis of non-alcoholic fatty liver disease (NAFLD)显示文摘 | P. Puri R.A. Baillie M. Wiest F. Mirshahi A.J. Sanyal | 2006 | Journal of Hepatology2006，，： | 2 |
| 5 | Effects of N ‐acetylcysteine on cytokines in non‐acetaminophen acute liver failure: potential mechanism of improvement in transplant‐free survival显示文摘 | R. Todd Stravitz Arun J. Sanyal Joan Reisch Jasmohan S. Bajaj Farid Mirshahi Jenfeng Cheng William M. Lee | 2013 | Liver Int2013，，9： | 2 |
| 6 | Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities显示文摘 | SANYAL A J CAMPBELL SARGENT C MIRSHAHI F | 2001 | Gastroenterology2001，120，5： | 1 |
| 7 | Ethanol inhibition of N-methyl-D-aspartate receptor is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue显示文摘 | Mirshahi T Woodward J J | 2001 | J Biol Chem2001，276，44： | 1 |
| 8 | Physiologic concentrations of leptin increase collagen production by non-immortalized human hepatic stellate cell显示文摘 | CHOUDHURY J MIRSHAHI F MURTHY K S | 2006 | Metab Clin Exp2006，55，： | 1 |
| 9 | Activation and dysregulation of theunfolded protein response in nonalcoholic fatty liver disease显示文摘 | Puri P Mirshahi F Cheung O | 2008 | Gas-troenterology2008，134，2： | 1 |
| 10 | Non-alcoholic steatohepatitis:association of insulin resistance and mitochondrial abnormalities显示文摘 | Sanyal AJ Campbell-Sargent C Mirshahi F | 2001 | Gastroenterology2001，120，5： | 1 |
| 11 | Clot structure modification by fondaparinux and consequence on fibrinolysis:a new mechanism of antithrombotic activity显示文摘 | VARIN R MIRSHAHI S MIRSHAHI P | 2007 | Thromb Haemost2007，97，： | 1 |
| 12 | Malignant hematopoieticcells induce an increased expression of VEGFR-1 and VEGFR-3on bone marrow endothelial cells via AKT and mTOR signallingpathways显示文摘 | Mirshahi P Toprak SK Faussat AM | | 0，，03： | 1 |
| 13 | Nonalcohol- ic steatohepatitis : association of insulin resistance and mitochon- drial abnormalities 显示文摘 | Sanyal AJ Campbell - Sargent C Mirshahi F | 2001 | Gasteroenterology2001，120，5： | 1 |
| 14 | Vasculogenic mimicry of a-cute leukemic bone marrow stromal cells显示文摘 | Mirshahi P Rafii A Vincent L | 2009 | Leukemia2009，23，6： | 1 |
| 15 | Endothelial ceils lining transjugular intrahepatic portasystemie shunts originate in hepatic sinusoids: implications for pseudointimal hyperplasia 显示文摘 | Sanyal A J Mirshahi F | 1999 | Hepatology1999，29，： | 1 |
| 16 | SDF-1 activity on microva-scular endothelial cells:consequences oil angiogenesis in vitro and in vivo models显示文摘 | Mirshahi F Pourtau J Li H | 2000 | Thromb Res2000，99，6： | 1 |
| 17 | Nonalcoholic steatohepatitis:association of insulin resistance and mitochondrial abnormalities显示文摘 | Sanyal AJ Campbell-Sargent C Mirshahi F | | 0，，： | 1 |
| 18 | Nonalcoholic steatohepatitis:association of insulin resistance and mitochondrial abnormalities显示文摘 | Sanyal AJ Campbell-Surgent C Mirshahi F | 2001 | Gasteroenterology2001，120，5： | 1 |
| 19 | SDF-1 activity on microvascular endothelial cells:Consequences on angiogenesis in Vitro and in Vivo models显示文摘 | Mirshahi F Pourtau J Li H | 2000 | Thrombosis Research2000，99，： | 1 |
| 20 | Nonalcoholic steatohepatitis:association of insulin resistance and mitochondrial abnormalities显示文摘 | Sanyal AJ Campbell-sargent C Mirshahi F | 2001 | Gastroenterology2001，120，： | 1 |
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