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| 1 | Liver transplantation for alcoholic liver disease显示文摘Alcoholic liver disease(ALD) is the second commonest indication for liver transplantation after viral hepatitis in the United States and Europe.Controversies surround the indications and allocation of scarce and expensive resource for this so called self inflicted disease.Controversies stem from the apprehension that alcoholic recipients are likely to relapse and cause damage to the graft.There is a need to select those candidates with lower risk for relapse with the available predictive factors and scores.Substance abuse specialist and psychiatrists are mandatory in the pre-transplant evaluation and in the post-transplant follow-up.There is conflicting evidence to support a fixed period of pretransplant abstinence,although most units do follow this.Alcoholic hepatitis(AH) continues to be a contraindication for transplantation,however there is a need for further research in this f ield as a subset of patients with AH who do not respond to medical treatment,have high early mortality and could benefit from transplantation.One year,3-year,and 5-year survival post-transplant is similar for both ALD and non-ALD recipients.The incidence of post-transplant rejection and retransplantation is also similar to other recipients.ALD with viral hepatitis especially hepatitis C virus leads to a more aggressive liver disease with early presentation for transplantation.ALD patients are more prone to develop de-novo malignancy;this is attributed to the long term effect of alcohol,tobacco combined with immunosuppression.Post-transplant surveillance is important to detect early relapse to alcoholism,presence of de-novo malignancy and treat the same adequately. | Vibha Varma Kerry Webb Darius F Mirza | 2010 | World Journal of Gastroenterology2010，16，35： | 6 |
| 2 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 3 | 胰十二指肠切除术中有血管切除的结果:来自欧洲两个中心对于生存率及无瘤生存的详细因素分析显示文摘该研究的目的是报道欧洲两个肝胰胆外科中心在胰十二指肠切除过程中进行血管切除的经验,并且评估结果及预后因素。1989-2002年两中心共45例因胰腺肿瘤行胰十二指肠切除术的病人,其中男21例、女24例,平均年龄(60±13)岁,(26~82岁);行Whipple's 33例,全胰切除10例,胰体尾、脾脏切除2例。同时切除的血管包括静脉39例、动脉1例、静脉加动脉5例。结果显示:无手术死亡,术后死亡率为2.2%。34例术后病程无大的波动。 | Adham M Mirza DF Chapuis F 黄辉(摘) 邹一平(校) | 2007 | 中华肝胆外科杂志2007，13，9： | 2 |
| 4 | Long-term outomes for laparoscopic versus open resection of nonmetastatic colorectal cancer 显示文摘 | Mirza MS Longman RJ Farrokhyar F | 2008 | J Laparoendosc Adv Surg Tech A2008，18，5： | 1 |
| 5 | Arginine and urea metabolism in the liver graft: a study using microdialysis in human orthotopic liver transplantation显示文摘 | SILVA M A MIRZA D F BUCKELS J A | 2006 | Transplantation2006，82，10： | 1 |
| 6 | Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer显示文摘 | Sharaiha RZ Halazun KJ Mirza F | | 0，，12： | 1 |
| 7 | An elastoplastic constitutive model for concrete显示文摘 | Pietruszczak S Jiang J Mirza F A | 1988 | International Journal of Solids and Structures1988，24，7： | 1 |
| 8 | Hyperdynamic upper esophageal sphincter pressure: a manometric observation in patients reporting globus sensation显示文摘 | Kwiatek MA Mirza F Kahrilas PJ | 2009 | Am J Gastroenterol2009，104，28： | 1 |
| 9 | Breast-conservation therapy in early-stage breast cancer patients with a positive family history 显示文摘 | Vlastos G Mirza NQ Meric F | 2002 | Ann Surg Oncol2002，9，9： | 1 |
| 10 | Breast cancer on the World Wide Web:Cross sectional survey of quali- ty of information and popularity of wehsites显示文摘 | Meric F Bernstam E V Mirza N Q | 2002 | BMJ2002，324，7337： | 1 |
| 11 | Positive surgical margins and ipsilateral breast tumor recurrence predict disease specific survival after breast conserving therapy 显示文摘 | Meric F Mirza NQ Vlastos G | 2003 | Cancer2003，97，4： | 1 |
| 12 | Elevated preoperative neutrophil: lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer 显示文摘 | Sharaiha RZ Halazun KJ Mirza F | 2011 | AnnSurgOneol2011，18，12： | 1 |
| 13 | Transversus abdomi- nis plane blocks for rescue analgesia after cesarean delivery: a case series显示文摘 | Mirza'F Carvalho B | 2014 | Obstet- ric Anesthesia Digest2014，34，1： | 1 |
| 14 | An elastoplastic constitutive model for concrete显示文摘 | PIETRUSZCZAK S JIANG J MIRZA F A | 1988 | International Journal of Solids and Structures1988，24，7： | 1 |
| 15 | Long-term complications associated with breast-conservation surgery and radiotherapy 显示文摘 | Meric F Buchholz TA Mirza NQ | 2002 | Ann Surg Oncol2002，9，6： | 1 |
| 16 | Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence显示文摘 | Smith CL Dunbar PR Mirza F | 2005 | Int J Cancer2005，113，2： | 1 |
| 17 | Mechanical Properties of Polypropylene Fiber Reinforced Concrete and the Effects of Pozzolanic Materials显示文摘 | Alhozaimy A M Soroushian P Mirza F | 1996 | Cement and Concrete Composites1996，，18： | 1 |
| 18 | Vertebroplasty learn- ing more, but not enough 显示文摘 | JARVIK J G KALLMES D F MIRZA SK | 2003 | Spine2003，28，14： | 1 |
| 19 | Mechanical prop- erties of polypropylene fiber reinforced concrete and effects of poi- iolanic显示文摘 | ALHOZAIMY A M SOROUSHIAN P MIRZA F | 1996 | Cement and Concrete Composites1996，，18： | 1 |
| 20 | Electrochemical oxidation of pyrite samples with known composition and electrical properties显示文摘 | Doyle F M Mirza AH | 1996 | Electrochemi- cal Proceedings1996，96，6： | 1 |
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