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| 1 | Promoter hypomethylation regulates CD133 expression in human gliomas显示文摘大脑开始肿瘤的房间(BTIC ) 对房间表面蛋白质 CD133 用抗体被充实;然而,生物关联和在人的 gliomas 的 CD133 表示的规章的机制还没被理解。在这研究,我们开始证明 CD133 是在 CD133 积极的房间焦点地作为在哪儿被观察的高级人的 glioblastomas 的 overexpressed 一微簇。另外,有 exon 1A, 1B,或 1C 的 CD133 抄本主要在 glioblastomas 被表示。阐明调整 CD133 的这异常表情的机制,包含一个 CpG 岛的三个近似倡导者(P1, P2,和 P3 ) 被孤立。在 U251MG 和 T98G glioblastoma 房间, P1 区域 flanking exon 1A 在三个倡导者之中展出了最高的活动,并且这项活动显著地被使失去活性由在 vitro methylation。在有 demethylating 代理人 5-azacytidine 或 histone deacetylase 禁止者 valproic 酸的处理以后, CD133 mRNA 的表示水平显著地在 glioma 房间被恢复。重要地,在 P1, P2,和 P3 区域以内的 CpG 地点的 hypomethylation 被与丰富的 CD133 mRNA 在人的 glioblastoma 纸巾定序的重亚硫酸盐观察。一起拿,我们的结果显示 DNA hypomethylation 是在 glioblastomas 的 CD133 表示的一个重要决定因素,并且这个 epigenetic 事件可以与表示 CD133 的 BTIC 的发展被联系。 | Kouichi Tabu Ken Sasail Taichi Kimura Lei Wang Eiko Aoyanagil Shinji Kohsaka Mishie Tanino Hiroshi Nishihara Shinya Tanaka | 2008 | Cell Research2008，18，10： | 2 |
| 2 | IDH1 mutation as a potential novel biomarker for distinguishing pseudoprogression from true progression in patients with glioblastoma treated with temozolomide and radiotherapy显示文摘 | Hiroaki Motegi Yuuta Kamoshima Shunsuke Terasaka Hiroyuki Kobayashi Shigeru Yamaguchi Mishie Tanino Junichi Murata Kiyohiro Houkin | 2013 | Brain Tumor Pathology2013，，2： | 1 |
| 3 | Decreased prosfaglandin E2 synfhesis by lens epithelial cells cultured on heparin-suvface-modified poly显示文摘 | Nishi O Mishi M | 1996 | J Catarat Refract Surg1996，22，5： | 1 |
| 4 | Isolation and chemical characterization of polysaecharides from iwatake,gyrophora esculenta miyoshi显示文摘 | Sone Y Isoda-Johmura M Mishi A | 1996 | Biosei Biotech Biochem1996，60，2： | 1 |
| 5 | ^(18)F-FDG PET/CT imaging for a gastrointestinal mantle cell lymphoma with multiple lymphomatous polyposis显示文摘Multiple lymphomatous polyposis(MLP)is an uncommon type of gastrointestinal lymphoma characterized by the presence of multiple polyps along the gastrointestinal tract.Most of this entity is in fact considered the counterpart of gastrointestinal tract involvement for mantle cell lymphoma(MCL).To our knowledge,there have been no reports on[fluorine-18]-fluorodeoxy-glucose(18F-FDG)-positron emission tomography(PET)/computed tomography(CT)imaging for gastrointestinal MCL with MLP.We present the results of 18F-FDG PET/CT imaging in a patient with gastrointestinal tract involvement of MCL showing continuous MLP from the stomach to the rectum and intestinal intussusception.FDG-PET/CT findings were false negative in typical MLP spreading widely over the gastrointestinal tract,but uptake was noted in large lesions with deep infiltration considered atypical as MLP.On FDG-PET/CT imaging,the Ki-67proliferative index,which is a cell proliferation marker,showed neither correlation with the presence of uptake nor the maximum standardized uptake value. | Makoto Saito Masaya Miyazaki Mishie Tanino Shinya Tanaka Kencho Miyashita Koh Izumiyama Akio Mori Tatsuro Irie Masanori Tanaka Masanobu Morioka Eriko Tsukamoto | 2014 | World Journal of Gastroenterology2014，20，17： | 1 |
| 6 | dereased prostaglandin E2 synthesis by lens epithelial cells cultured on heparin-surface-modified poly 显示文摘 | Nishi O Mishi K Imanishi M | 1996 | J Cataract Refract Surg1996，22，5： | 1 |
| 7 | Highly efficient electrogene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene 显示文摘 | Goto T Mishi T Tamura T | 2000 | Proc Natl Acad Sci USA2000，97，1： | 1 |
| 8 | Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma显示文摘 | Yasutaka Kato Hiroshi Nishihara Hiromi Mohri Hiromi Kanno Hiroyuki Kobayashi Taichi Kimura Mishie Tanino Shunsuke Terasaka Shinya Tanaka | 2014 | Brain Tumor Pathology2014，，1： | 1 |
| 9 | Decreased prostaglandin E2 synthesis by lens epithelial cells cultured on heparin - surface - modified poly 显示文摘 | Nishi O Mishi K Imanishi M | 1996 | J Cataract Refract Surg1996，22，5： | 1 |
| 10 | Decreased prostaglandin E2 synthesis by lensepitheial cells cultured on heparin - surface - modified poly显示文摘 | Nishi O Mishi K Imanishi M | 1996 | J Cataract Refract Surg1996，22，5： | 1 |
| 11 | Dereased prostaglandin E2 synthesis by lens epithelial cells cultured on heparin-surface-modified poly显示文摘 | Nishi O Mishi K Imanishi M | | 0，，05： | 1 |
| 12 | Contribution of germline BRCA1 and BRCA2 sequence alterations to breast cancer in Northern India显示文摘 | Sunita Saxena Anurupa Chakraborty Mishi Kaushal | 2006 | BMC Medical Genetics2006，7，： | 1 |
| 13 | ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review显示文摘BACKGROUND Anaplastic large cell lymphoma(ALCL)is a type of T-cell lymphoma that can be divided into two categories:anaplastic lymphoma kinase-positive(ALK+)and ALK-negative.Gastrointestinal ALK+ALCL is rare.Multiple lymphomatous polyposis(MLP)is thought to be a representative form of gastrointestinal lesion in mantle cell lymphoma,and T-cell lymphomas seldom show this feature.Here,we report the first known case of ALK+ALCL with gastroduodenal involvement to present with MLP.CASE SUMMARY The patient was a 43-year-old man who was complained of a mass in the left inguinal area and was performed open biopsy.ALK+ALCL was diagnosed pathologically.Computed tomography scan demonstrated multiple lymph node lesions in the abdomen-pelvis/inguinal region,and scattered nodular lesions in both lung fields.He did not complain of gastrointestinal symptoms.While,esophagogastroduodenoscopy identified MLP lesions from the antrum of the stomach to the descending portion of the duodenum and mild thickened folds on the corpus of the stomach,and biopsy showed invasion of ALK+ALCL.We treated this patient with six cycles of CHOEP(Cyclophosphamide,Doxorubicin,Vincristine,Etoposide,and Prednisone)chemotherapy.At the conclusion of treatment,there was complete remission.Numerous white scars were found on the stomach,endoscopically consistent with a remission image of lymphoma.The endoscopic features of this case were thought to be similar to those of MCL.CONCLUSION The macroscopic/endoscopic features of gastrointestinal ALK+ALCL may be more similar to those of B-cell lymphomas rather than T-cell lymphomas. | Makoto Saito Koh Izumiyama Reiki Ogasawara Akio Mori Takeshi Kondo Masanori Tanaka Masanobu Morioka Kencho Miyashita Mishie Tanino | 2019 | World Journal of Clinical Cases2019，7，15： | 0 |
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