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| 1 | Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma显示文摘AIM To investigate the expression and prognostic role of programmed death ligand-1(PD-L1) in locally advanced esophageal squamous cell carcinoma(ESCC).METHODS A total of 200 patients with ESCC who underwent radical esophagectomy with standard lymphadenectomy as the initial definitive treatment in Seoul National University Hospital from December 2000 to April 2013 were eligible for this analysis. Tissue microarrays were constructed by collecting tissue cores from surgical specimens, and immunostained with antibodies directed against PD-L1, p16, and c-Met. Medical records were reviewed retrospectively to assess clinical outcomes. Patients were divided into two groups by PD-L1 status, and significant differences in clinicopathologic characteristics between the two groups were assessed. RESULTS Tumor tissues from 67 ESCC patients(33.5%) were PDL1-positive. Positive p16 expression was observed in 21 specimens(10.5%). The H-score for c-Met expression was ≥ 50 in 42 specimens(21.0%). Although PDL1-positivity was not significantly correlated with any clinical characteristics including age, sex, smoking/alcoholic history, stage, or differentiation, H-scores for c-Met expression were significantly associated with PDL1-positivity(OR = 2.34, 95%CI: 1.16-4.72, P = 0.017). PD-L1 expression was not significantly associated with a change in overall survival(P = 0.656). In contrast, the locoregional relapse rate tended to increase(P = 0.134), and the distant metastasis rate was significantly increased(HR = 1.72, 95%CI: 1.01-2.79, P = 0.028) in patients with PD-L1-positive ESCC compared to those with PD-L1-negative ESCC.CONCLUSION PD-L1 expression is positively correlated with c-Met expression in ESCC. PD-L1 may play a critical role in distant failure and progression of ESCC. | Ryul Kim Bhumsuk Keam Dohee Kwon Chan-Young Ock Miso Kim Tae Min Kim Hak Jae Kim Yoon Kyung Jeon In Kyu Park Chang Hyun Kang Dong-Wan Kim Young Tae Kim Dae Seog Heo | 2016 | World Journal of Gastroenterology2016，22，37： | 14 |
| 2 | The anti-angiogenic herbal extract from Melissa officinalis inhibits adipogenesis in 3T3-L1 adipocytes and suppresses adipocyte hypertrophy in high fat diet-induced obese C57BL/6J mice显示文摘 | Sangee Woo Miso Yoon Jeongjun Kim Yeonhee Hong Min-Young Kim Soon Shik Shin Michung Yoon | 2016 | Journal of Ethnopharmacology2016，，： | 1 |
| 3 | Characterization of lattice parameters gradient of Cu(In1-xGax)Se2 absorbing layer in thin-film solar cell by glancing incidence X-ray diffraction technique显示文摘In or Ga gradients in the Cu(In1-xGax)Se2(CIGS)absorbing layer lead to change the lattice parameters of the absorbing layer,giving rise to the bandgap grading in the absorbing layer which is directly associated with the degree of absorbing ability of the CIGS solar cell.We tried to characterize the depth profile of the lattice parameters of the CIGS absorbing layer using a glancing incidence X-ray diffraction(GIXRD)technique,and then investigate the bandgap grading of the CIGS absorbing layer.When the glancing incident angle increased from 0.50 to 5.00°,the a and c lattice parameters of the CIGS absorbing layer gradually decreased from 5.7776(3)to 5.6905(2)?,and 11.3917(3)to 11.2114(2)?,respectively.The depth profile of the lattice parameters as a function of the incident angle was consistent with vertical variation in the compositionof In or Ga with depth in the absorbing layer.The variation of the lattice parameters was due to the difference between the ionic radius of In and Ga co-occupying at the same crystallographic site.According to the results of the depth profile of the refined parameters using GIXRD data,the bandgap of the CIGS absorber layer was graded over a range of 1.222-1.532 eV.This approach allows to determine the In or Ga gradients in the CIGS absorbing layer,and to nondestructively guess the bandgap depth profile through the refinement of the lattice parameters using GIXRD data on the assumption that the changes of the lattice parameters or unit-cell volume follow a good approximation to Vegard’s law. | Yong-Il Kim Ki-Bok Kim Miso Kim | 2020 | Journal of Materials Science & Technology2020，47，16： | 0 |
| 4 | Circulating small extracellular vesicles promote proliferation and migration of vascular smooth muscle cells via AXL and MerTK activation显示文摘The proliferation and migration of vascular smooth muscle cells(VSMCs)after vascular injury lead to neointimal hyperplasia,thus aggravating vascular diseases.However,the molecular mechanisms underlying neointima formation are not fully elucidated.Extracellular vesicles(EVs)are mediators of various intercellular communications.The potential of EVs as regulators in cardiovascular diseases has raised significant interest.In the current study we investigated the role of circulating small extracellular vesicles(csEVs),the most abundant EVs(10^(10)EVs/mL serum)in VSMC functions.csEVs were prepared from bovine,porcine or rat serum.We showed that incubation with csEVs(0.5×10^(10)−2×10^(10))dose-dependently enhanced the proliferation and migration of VSMCs via the membrane phosphatidylserine(PS).In rats with ligation of right carotid artery,we demonstrated that application of csEVs in the ligated vessels aggravated neointima formation via interaction of membrane PS with injury.Furthermore,incubation with csEVs markedly enhanced the phosphorylation of AXL and MerTK in VSMCs.Pretreatment with BSM777607(pan-TAM inhibitor),bemcentinib(AXL inhibitor)or UNC2250(MerTK inhibitor)blocked csEV-induced proliferation and migration of VSMCs.We revealed that csEV-activated AXL and MerTK shared the downstream signaling pathways of Akt,extracellular signal-regulated kinase(ERK)and focal adhesion kinase(FAK)that mediated the effects of csEVs.We also found that csEVs increased the expression of AXL through activation of transcription factor YAP,which might constitute an AXL-positive feedback loop to amplify the signals.Finally,we demonstrated that dual inhibition of AXL/MerTK by ONO-7475(0.1μM)effectively hindered csEV-mediated proliferation and migration of VSMCs in ex vivo mouse aorta injury model.Based on these results,we propose an essential role for csEVs in proliferation and migration of VSMCs and highlight the feasibility of dual AXL/MerTK inhibitors in the treatment of vascular diseases. | Young Joo Lee Miso Park Hyun Young Kim Jin-Ki Kim Won-Ki Kim Sung Chul Lim Keon Wook Kang | 2023 | Acta Pharmacologica Sinica2023，44，5： | 0 |
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