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| 1 | MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors显示文摘AIM:To clarify differences in mucin phenotype, prolif-erative activity and oncogenetic alteration among subtypes of colorectal laterally spreading tumor (LST). METHODS:LSTs, defined as superficial elevated lesions greater than 10 mm in diameter with a low vertical axis, were macroscopically classified into two subtypes:(1) a granular type (Gr-LST) composed of superficially spreading aggregates of nodules forming a flat-based lesion with a granulonodular and uneven surface; and (2) a non-granular type (NGr-LST) with a flat smooth surface and an absence of granulonodular formation. A total of 69 LSTs, comprising 36 Gr-LSTs and 33 NGr-LSTs, were immunohistochemically stained with MUC2, MUC5AC,MUC6, CD10 (markers of gastrointestinal cell lineage), p53, β-catenin and Ki-67 antibodies, and examined for alteration in exon 1 of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and exon 15 of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) by poly-merase chain reaction followed by direct sequencing. RESULTS:Histologically, 15 Gr-LST samples were adenomas with low-grade dysplasia (LGD), 12 were high-grade dysplasia (HGD) and 9 were adenocarcinomas invading the submucosa (INV), while 12 NGr-LSTs demonstrated LGD, 14 HGD and 7 INV. In the proximal colon, MUC5AC expression was significantly higher in the Gr-type than the NGr-type. MUC6 was expressed only in NGr-LST. MUC2 or CD10 did not differ. P53 expression demonstrated a significant stepwise increment in progression through LGD-HGD-INV with both types of LST. Nuclear β-catenin expression was significantly higher in the NGr-type. Ki-67 expression was signifi-cantly higher in the Gr-type in the lower one third zone of the tumor. In proximal, but not distal colon tumors, the incidence of KRAS provided mutation was signifi-cantly higher in the Gr-type harboring a specific mutational pattern (G12V). BRAF mutations (V600E) were detected only in two Gr-LSTs. CONCLUSION:The two subtypes of LST, especially in the proximal colon, have differing phenotypes of gastrointestinal cell lineage, proliferation and activation of Wnt/β-catenin or RAS/RAF/extracellular signal-regulated kinase signaling. | Kosaburo Nakae Hiroyuki Mitomi Tsuyoshi Saito Michiko Takahashi Takashi Morimoto Yasuhiro Hidaka Naoto Sakamoto Takashi Yao Sumio Watanabe | 2012 | World Journal of Gastroenterology2012，18，39： | 8 |
| 2 | Broad-band tunable two-section laser diode with external grating feedback显示文摘 | Notomi M Mitomi O Yoshikuni Y | 1990 | IEEE Photonics Technology Letters1990，2，2： | 2 |
| 3 | Expansion of the indications for endoscopic mucosal resection in patients with superficial esophageal carcinoma显示文摘 | K. Higuchi S. Tanabe W. Koizumi T. Sasaki K. Nakatani K. Saigenji N. Kobayashi H. Mitomi | 2007 | Endoscopy2007，，01： | 2 |
| 4 | 75GHz Broadband Ti: LiNbO3 Optical Modulator with Ridge Structure显示文摘 | NOGUCHI K MIYAZAWA H MITOMI O | 1989 | Electron Lett1989，30，： | 1 |
| 5 | Clinical out- come of endoscopic aspiration mucosectomy for early stage gastric cancer 显示文摘 | TANAEB S KOIZUMI W MITOMI H | 2002 | Gastrointest Endosc2002，56，5： | 1 |
| 6 | Comparison of longterm outcome of laparoscopic and conventional surgery for advanced colon and rectosigmoid cancer显示文摘 | Nakamura T Mitomi H Ohtani Y | 2006 | Hepatogastroenterology2006，53，69： | 1 |
| 7 | Design of a single-mode tapered waveguide for low-loss chip-to-fiber coupling显示文摘 | MITOMI O KASAYA K MIYAZAWA H | 1994 | IEEE Journal of Quantum Electronics1994，30，8： | 1 |
| 8 | Gastrointestinal stromal tumor of the rectum resected by laparoscopic surgery:report of a case显示文摘 | Nakamura T Ihara A Mitomi H | 2007 | Surg Today2007，37，11： | 1 |
| 9 | Enhanced cellular proliferation and p53 accumulation in gastric mucosa chronically infected with Helicobacter pylori 显示文摘 | HIBI K MITOMI H KOIZUMI W | 1997 | Am J Clin Pathol1997，108，1： | 1 |
| 10 | Enhanced cellular proliferation and p53 accumulation in gastric mucus chronically infected with helicobacter pylori 显示文摘 | Hibi K Mitomi H Koizumi W | 1997 | Am J Clin Ptuol1997，108，1： | 1 |
| 11 | Retrospective,matched case-control study comparing the oncologic outcomes between laparoscopic surgery and open surgery in patients with fight-sided colon cancer显示文摘 | Nakamura T Onozato W Mitomi H | 2009 | Surg Today2009，39，12： | 1 |
| 12 | Gut bacterial translocation during total parenteral nutrition in experimental rats and its countermeasure显示文摘 | Nakasaki H Mitomi T Tajima T | 1998 | Am J Surg1998，175，1： | 1 |
| 13 | Risk factors for wound infection after surgery for colorectal cancer显示文摘 | Nakamura T Mitomi H Ihara A | 2008 | World J Surg2008，32，6： | 1 |
| 14 | Downregulation of sFRP-2 by epigenetic silencing activates the β-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma显示文摘 | Tsuyoshi Saito Hiroyuki Mitomi Abdukadir Imamhasan Takuo Hayashi Keiko Mitani Michiko Takahashi Yoshiaki Kajiyama Takashi Yao | 2014 | Virchows Archiv2014，，2： | 1 |
| 15 | Broad2band Tunable two2 Section Laser Diode with External Grating Feedback显示文摘 | NOTOMI M MITOMI O YOSHIKUNI Y | 1990 | IEEE Photonics Technology Letters1990，，2： | 1 |
| 16 | A review of clinical fea-tures in 13 eases of impacted primary teeth显示文摘 | Ostuka Y Mitomi T Tomizawa M | 2001 | Int J PaediatrDent2001，11，1： | 1 |
| 17 | CD44 variant overexpression in gallbladder carcinoma associated with tumor dedifferentiation显示文摘 | Yanagisawa N Mikami T Mitomi H | 2001 | Cancer2001，91，2： | 1 |
| 18 | Correction of Atmosphere Effect on ADEOS/OCTS Ocean Color Data:Algorithm Description and Evaluation of Its Performance显示文摘 | Fukushima H Higurashi A Mitomi Y | 1998 | Journal of Oceanography1998，54，： | 1 |
| 19 | Downregulation of s FRP-2by epigenetic silencing activates theβ-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma显示文摘 | Saito T Mitomi H Imamhasan A | 2014 | Virchows Arch2014，464，20： | 1 |
| 20 | Abnormal expression of p16(INK4a),cyclin D1,cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas显示文摘 | Kishimoto I Mitomi H Ohkura Y | 2008 | J Surg Oncol2008，98，1： | 1 |
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