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| 1 | Short-and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors显示文摘BACKGROUND It is widely recognized that endoscopic resection(ER) of superficial nonampullary duodenal epithelial tumors(SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and perforation.These adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short-and long-term outcomes have not been standardized yet.AIM To investigate the curability including short-and long-term outcomes of ER for SNADETs in a large case series.METHODS This retrospective study included cases that underwent ER for SNADETs at our university hospital between March 2004 and July 2017. Short-term outcomes of ER were measured based on en bloc and R0 resection rates as well as adverse events. Long-term outcomes included local recurrence detected on endoscopic surveillance and disease-specific mortality in patients followed up for ≥ 12 mo after ER.RESULTS In the study, 131 patients with 147 SNADETs were analyzed. The 147 ERs consisted of 136 endoscopic mucosal resections(EMRs)(93%) and 11 endoscopic submucosal dissections(ESDs)(7%). The median tumor diameter was 10 mm.The pathology diagnosis was adenocarcinoma(56/147, 38%), high-grade intraepithelial neoplasia(44/147, 30%), or low-grade intraepithelial neoplasia(47/147, 32%). The R0 resection rate was 68%(93/136) in the EMR group and73%(8/11) in the ESD group, respectively. Cap-assisted EMR(known as EMR-C)showed a higher rate of R0 resection compared to the conventional method of EMR using a snare(78% vs 62%, P = 0.06). No adverse event was observed in the EMR group, whereas delayed bleeding, intraoperative perforation, and delayed perforation in 3, 3, and 5 patients occurred in the ESD group, respectively. One patient with perforation required emergency surgery. In the 43 mo median follow-up period, local recurrence was found in four EMR cases and all cases were treated endoscopically. No patient died due to tumor recurrence.CONCLUSION Our findings suggest that ER provides good long-term outcomes in the patients with SNADETs. EMR is likely to become the safe and reliable treatment for small SNADETs. | Yuko Hara Kenichi Goda Akira Dobashi Tomohiko Richard Ohya Masayuki Kato Kazuki Sumiyama Takehiro Mitsuishi Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 2 | Stand structure and dynamics during a 16-year period in a sub-boreal conifer-hardwood mixed forest ,northern Japan显示文摘 | TAKAHASHI K MITSUISHI D UEMURA S | 2003 | Forest Ecology and Management2003，174，： | 1 |
| 3 | Characterization of the free-carrier concentrations in doped β- SiC crystals by Raman scattering显示文摘 | Yugami H Nakashima S Mitsuishi A | 1987 | J Appl Phys1987，61，： | 1 |
| 4 | Tenascin-C is upregulated in the skin lesions of patients with atopic dermatitis显示文摘 | Kaoru Ogawa Mikito Ito Kaori Takeuchi Akiko Nakada Masayuki Heishi Hajime Suto Kouichi Mitsuishi Yuji Sugita Hideoki Ogawa Chisei Ra | 2005 | Journal of Dermatological Science2005，，： | 1 |
| 5 | Absorption and desorption of hydrogen from inert gas mixtures with a Zr3A12 particle bed显示文摘 | Nobuo Mitsuishi Seiichi Sato Satoshi Fukada | 1995 | Fusion Engineering and Design1995，28，： | 1 |
| 6 | Networked Manufacturing with Reality Sensation for Technology Transfer显示文摘 | Takaaki Nagao | 1999 | Annals of the CIRP1999，48，1： | 1 |
| 7 | Immune?maximizing (IMAX) therapy for cancer: Combination of dendriticcell vaccine and intensity?modulated radiation显示文摘 | Yuta Shibamoto Masato Okamoto Masanori Kobayashi Shiho Ayakawa Hiromitsu Iwata Chikao Sugie Yoko Mitsuishi Hidenori Takahashi | 2013 | Molecular and Clinical Oncology2013，，： | 1 |
| 8 | Determination of Structural Isomers of Xyloglucan Octasaccharides Using Post-source Decay Fragment Analysis in MALDI-TOF Mass Spectrometry显示文摘 | Yamagaki T Mitsuishi Y Nakanishi H | 1998 | Tetrahedron Letts1998，39，35： | 1 |
| 9 | Non-newtonian flow in non-circular duct显示文摘 | Nobuo Mitsuishi Yoshifumi Kitayama Yoshiki Aoyagi | 1966 | Chemical Engineering Japan1966，31，6： | 1 |
| 10 | Association of the physical activity of community-dwelling older adults with transportation modes, depression and social networks显示文摘 | Tsunoda K Mitsuishi Y Tsuji T | 2011 | Nihon Ronen Igakkai Zasshi2011，48，51： | 1 |
| 11 | Human papillomavirus infection in actinic keratosis and bowen's disease:comparative study with expression of cell-cycle regulatory proteins p21(Waf1/Cip1),p53,PCNA,Ki-67,and Bcl-2 in positive and negative lesions显示文摘 | Mitsuishi T Kawana S Kato T | 2003 | Hum Pathol2003，34，9： | 1 |
| 12 | Crystallization behavior of polypropylene filled with surface-modified calcium carbonate显示文摘 | K Mitsuishi S Ueno S Kodama | 1991 | J Appl Polym Sci1991，43，： | 1 |
| 13 | Com- bined analysis of cell growth and apoptosis-regulating pro- teins in HPVs associated anogenital tumors 显示文摘 | MITSUISHI T IWABU Y TOKUNAGA K | 2010 | BMC Cancer2010，10，： | 1 |
| 14 | Stand structure and dy- namics during a 16-year period in a sub-boreal conifer-hardwood mixed forest, northern Japan 显示文摘 | Takahashi K Mitsuishi D Uemura S | 2003 | Forest Ecology and Management2003，3950，： | 1 |
| 15 | Luminescence Properties of Eu2+ -doped Green-emitting Sr-Sialon Phosphor and Its Application to White Light-emitting Diodes 显示文摘 | Fukuda Y Ishida K Mitsuishi I | 2009 | Appl Phys Express2009，2，1： | 1 |
| 16 | HLA association with Meniere' s disease显示文摘 | KOYAMA S MITSUISHI Y BIBEE K | 1993 | Acta Otolaryngol1993，113，5： | 1 |
| 17 | HLA associations with Menires disease 显示文摘 | Koyama S Mitsuishi Y Bibee K | 1993 | Acta Otolaryngol1993，113，5： | 1 |
| 18 | A case report of steroid and immunosuppressant-resistant pyoderma gangrenosum successfully treated by granulocytapheresis 显示文摘 | Okuma K Mitsuishi K Hasegawa T | 2007 | Ther Apher Dial2007，11，5： | 1 |
| 19 | Beta blocker improves survival left ventricular function,and myocardial remodeling in hypertensive rats with diastolic heart failure显示文摘 | Kobayashi M Machida N Mitsuishi M | 2004 | Am J Hypertens2004，17，12： | 1 |
| 20 | Power relay performance improves as sizes drop to sub-mini formats 显示文摘 | MITSUISHI SHOJI | 1993 | IEE Journal of Electronic Engineering1993，30，324： | 1 |
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