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| 1 | Endoscopic management for congenital esophageal stenosis: A systematic review显示文摘Congenital esophageal stenosis(CES) is an extremely rare malformation, and standard treatment have not been completely established. By years of clinical research, evidence has been accumulated. We conducted systematic review to assess outcomes of the treatment for CES, especially the role of endoscopic modalities. A total of 144 literatures were screened and reviewed. CES was categorized in fibromuscularthickening, tracheobronchial remnants(TBR) and membranous web, and the frequency was 54%, 30% and 16%, respectively. Therapeutic option includes surgery and dilatation, and surgery tends to be reserved for ineffective dilatation. An essential point is that dilatation for TBR type of CES has low success rate and high rate of perforation. TBR can be distinguished by using endoscopic ultrasonography(EUS). Overall success rate of dilatation for CES with or without case selection by using EUS was 90% and 29%, respectively. Overall rate of perforation with or without case selection was 7% and 24%, respectively. By case selection using EUS, high success rate with low rate of perforation could be achieved. In conclusion, endoscopic dilatation has been established as a primary therapy for CES except TBR type. Repetitive dilatation with gradual step-up might be one of safe ways to minimize the risk of perforation. | Keita Terui Takeshi Saito Tetsuya Mitsunaga Mitsuyuki Nakata Hideo Yoshida | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 8 |
| 2 | Dermatomyositis associated with hepatocellular carcinoma in an elderly female patient with hepatitis C virus-related liver cirrhosis显示文摘有丙肝的一个 79 岁的女病人病毒相关的肝肝硬化作为与 2.0 厘米的一条直径有肝细胞癌(HCC ) 被诊断。她为 HCC 拒绝了治疗。在诊断以后的九个月,当 HCC 扩大了到 6.0 厘米的一条直径时,她开发了皮肤肌炎。她为皮肤肌炎,然后 transcatheter 经历了治疗为 HCC 的动脉的 chemoembolization。尽管皮肤肌炎的表明改善了,全部肿瘤坏死被完成,她在 HCC 的治疗以后死于肺病 2 瞬间。HCC 或长期的丙肝病毒感染可能涉及皮肤肌炎的致病。 | Nobuyuki Toshikuni Rikako Torigoe Mikio Mitsunaga Akiyoshi Omoto Koji Nakashima | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 3 | Early apoptosis and cell death induced by ATX-S10Na(Ⅱ)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells显示文摘AIM: To investigate the roles of Bax and p53 proteins in photosensitivity of human colon cancer cells by using lysosome-localizing photosensitizer, ATX-S10Na (Ⅱ).METHODS: HCT116 human colon cancer cells and Bax-null or p53-null isogenic derivatives were irradiated with a diode laser. Early apoptosis and cell death in response to photodynamic therapy were determined by MTT assays, annexin V assays, transmission electron microscopy assays, caspase assays and western blotting.RESULTS: Induction of early apoptosis and cell death was Bax- and p53-dependent. Bax and p53 were required for caspase-dependent apoptosis. The levels of anti-apoptotic Bcl-2 family proteins, Bcl-2 and Bcl-xL, were decreased in Bax- and p53-independent manner.CONCLUSION: Our results indicate that early apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizing photosensitizer ATX-S10Na (Ⅱ) are mediated by p53-Bax network and low levels of Bcl-2 and Bcl-xL proteins. Our results might help in formulating new therapeutic approaches in photodynamic therapy. | Makoto Mitsunaga Akihito Tsubota Kohichi Nariai Yoshihisa Namiki Makoto Sumi Tetsuya Yoshikawa Kiyotaka Fujise | 2007 | World Journal of Gastroenterology2007，13，5： | 3 |
| 4 | Comparison of cerebral activation between motor execution and motor imagery of self-feeding activity显示文摘Motor imagery is defined as an act wherein an individual contemplates a mental action of motor execution without apparent action.Mental practice executed by repetitive motor imagery can improve motor performance without simultaneous sensory input or overt output.We aimed to investigate cerebral hemodynamics during motor imagery and motor execution of a self-feeding activity using chopsticks.This study included 21 healthy right-handed volunteers.The self-feeding activity task comprised either motor imagery or motor execution of eating sliced cucumber pickles with chopsticks to examine eight regions of interest:pre-supplementary motor area,supplementary motor area,bilateral prefrontal cortex,premotor area,and sensorimotor cortex.The mean oxyhemoglobin levels were detected using near-infrared spectroscopy to reflect cerebral activation.The mean oxyhemoglobin levels during motor execution were significantly higher in the left sensorimotor cortex than in the supplementary motor area and the left premotor area.Moreover,significantly higher oxyhemoglobin levels were detected in the supplementary motor area and the left premotor area during motor imagery,compared to motor execution.Supplementary motor area and premotor area had important roles in the motor imagery of self-feeding activity.Moreover,the activation levels of the supplementary motor area and the premotor area during motor execution and motor imagery are likely affected by intentional cognitive processes.Levels of cerebral activation differed in some areas during motor execution and motor imagery of a self-feeding activity.This study was approved by the Ethical Review Committee of Nagasaki University(approval No.18110801)on December 10,2018. | Moemi Matsuo Naoki Iso Kengo Fujiwara Takefumi Moriuchi Daiki Matsuda Wataru Mitsunaga Akira Nakashima Toshio Higashi | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 5 | Short-Segment Fixation of Lumbar Burst Fractures Using Pedicle Fixation at the Level of the Fracture显示文摘 | Andrew Mahar Choll Kim Michelle Wedemeyer Lance Mitsunaga Tim Odell Bryce Johnson Steven Garfin | 2007 | Spine2007，，14： | 3 |
| 6 | Impact of tumor‐associated macrophages on invasive ductal carcinoma of the pancreas head显示文摘 | Kiyoshi Yoshikawa Shuichi Mitsunaga Taira Kinoshita Masaru Konishi Shinichiro Takahashi Naoto Gotohda Yuichiro Kato Masaki Aizawa Atsushi Ochiai | 2012 | Cancer Sci2012，，11： | 2 |
| 7 | Identification of the targermolecule of cytotoxic T cells presumably responsible for develoment of transfusion associated graft-versus-host disease显示文摘 | Uchida S Mitsunaga S | 1996 | Transfusion1996，36，： | 1 |
| 8 | Two new triterpenoid saponins from platycodon grandiflorum显示文摘 | Nidaido T Koike K Mitsunaga K | 1999 | Chem PharmBull1999，47，6： | 1 |
| 9 | Detection of early esophageal and gastric cancers bymass screening显示文摘 | Mitsunaga N Tsubouchi H | 1996 | Nippon-Rinsho1996，54，5： | 1 |
| 10 | MR and optical imaging of early micrometastases in lymph nodes: triple labeling with nano-sized agents yielding distinct signals 显示文摘 | Kosaka N Bernardo M Mitsunaga M | 2012 | Contrast Media Mol Imaging2012，7，2： | 1 |
| 11 | Transfer of matemally administered fusogenic liposome - DNA complexes into monkey fetuses in a pregnancy model显示文摘 | Hirano M Nakamura S Mitsunaga F | 2002 | J Gene Med2002，4，5： | 1 |
| 12 | Short same-segment fixation of thoracolumbar burst fractures 显示文摘 | Eno J J Chen JL Mitsunaga MM | 2012 | Hawaii J Med Public Health2012，71，1： | 1 |
| 13 | High-throughput HBV DNA and HCV RNA detection system using a nucleic acid purification robot and real-time detection PCR: its application to analysis of post-transfusion hepatitis显示文摘 | Mitsunaga S Fujimura K Matsumoto C | 2002 | Transfusion2002，42，2： | 1 |
| 14 | Gastrointestinal diseases and halitosis association of gastric Helicobacter pylori infection显示文摘 | Hoshi K Yamano Y Mitsunaga A | 2002 | Int Dent J2002，52，3： | 1 |
| 15 | Two new triterpenoid saponins from platycodon grandiflorum 显示文摘 | Nikaido T Koike K Mitsunaga K | 1999 | Chem Pharm Bull1999，47，6： | 1 |
| 16 | Tirterpenoid saponins from root of Platycodon grandiflorum 显示文摘 | Nikaido T Koike K Mitsunaga K | 1998 | Nat Med1998，52，： | 1 |
| 17 | Short same - segment fixation ofthoracolumbar burst fractures 显示文摘 | Eno JJ Chen JL Mitsunaga MM | 2012 | Hawaii J Med Public Health2012，1，： | 1 |
| 18 | Short same-segment fixation of thoracolumbar burst fractures显示文摘 | Eno JJ Chen JL Mitsunaga MM | 2012 | Hawaii J Med Public Health2012，71，1： | 1 |
| 19 | Condylar nonunions of the elbow显示文摘 | Mitsunaga MM Bryan RS Linscheid RL | 1982 | J Trauma1982，22，： | 1 |
| 20 | New bergenin derivatives from Ardisia crenata显示文摘 | JIA Z H MITSUNAGA K KOIKE K | 1995 | Nat Med1995，49，2： | 1 |
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