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| 1 | Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis显示文摘AIM: To evaluate the effect of pyrrolidine dithio- carbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis. METHODS: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated groupⅠ(low-dose group), and DSS+PDTC-treated groupⅡ (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue were measured. RESULTS: The DSS+PDTC-treated groupⅡ exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels were significantly lower in DSS+PDTC- treated groupⅡ. CONCLUSION: These findings suggest that PDTC is useful for the treatment of ulcerative colitis. | Ichiro Hirata Shingo Yasumoto Ken Toshina Takuya Inoue Takashi Nishikawa Naoko Murano Mitsuyuki Murano Fang-Yu Wang Ken-ichi Katsu | 2007 | World Journal of Gastroenterology2007，13，11： | 20 |
| 2 | Endoscopic management for congenital esophageal stenosis: A systematic review显示文摘Congenital esophageal stenosis(CES) is an extremely rare malformation, and standard treatment have not been completely established. By years of clinical research, evidence has been accumulated. We conducted systematic review to assess outcomes of the treatment for CES, especially the role of endoscopic modalities. A total of 144 literatures were screened and reviewed. CES was categorized in fibromuscularthickening, tracheobronchial remnants(TBR) and membranous web, and the frequency was 54%, 30% and 16%, respectively. Therapeutic option includes surgery and dilatation, and surgery tends to be reserved for ineffective dilatation. An essential point is that dilatation for TBR type of CES has low success rate and high rate of perforation. TBR can be distinguished by using endoscopic ultrasonography(EUS). Overall success rate of dilatation for CES with or without case selection by using EUS was 90% and 29%, respectively. Overall rate of perforation with or without case selection was 7% and 24%, respectively. By case selection using EUS, high success rate with low rate of perforation could be achieved. In conclusion, endoscopic dilatation has been established as a primary therapy for CES except TBR type. Repetitive dilatation with gradual step-up might be one of safe ways to minimize the risk of perforation. | Keita Terui Takeshi Saito Tetsuya Mitsunaga Mitsuyuki Nakata Hideo Yoshida | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 8 |
| 3 | BRIEF ARTICLE New reduced volume preparation regimen in colon capsule endoscopy显示文摘AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed 'reduced volume method'(group A) with the 'conventional volume method'(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method. | Yasuo Kakugawa Yutaka Saito Shoichi Saito Kenji Watanabe Naoki Ohmiya Mitsuyuki Murano Shiro Oka Tetsuo Arakawa Hidemi Goto Kazuhide Higuchi Shinji Tanaka Hideki Ishikawa Hisao Tajiri | 2012 | World Journal of Gastroenterology2012，18，17： | 8 |
| 4 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 5 | Usefulness of fecal lactoferrin and hemoglobin in diagnosis of colorectal diseases显示文摘AIM:To evaluate prospectively usefulness of fecal lactoferrin(Lf)and fecal hemoglobin(Hb)in the diagnosis of colorectal diseases.METHODS:Fecal Lf and Hb were measured using ELISA in 872 patients before they underwent colorectal endoscopy.RESULTS:Lf was positive in 18(50%)of 36 patients with colorectal cancer,25(15.9%)of 157 with colorectal polyps,29(46.8%)of 62 with ulcerative colitis,and 25(62.5%)of 40(62.5%)with Crohn's disease.The Hb-positive rates were 50%,12.1%,41.9% and 32.5%,respectively.Of the 318 patients free of abnormalities by colorectal endoscopy,Lf was positive in 29(9.1%)and Hb was positive in 15(4.7%).Among patients with Crohn's disease,the Lf-positive rate was significantly higher than the Hb-positive rate.If either high Lf or Hb levels were considered positive,the positive rates rose to 61.1%,51.6%,and 67.5% in the colorectal cancer group,ulcerative colitis group,and Crohn's disease group,respectively.If both high Lf and Hb levels were rated positive,the positive predictive values(PPV)were 21% for colorectal cancer,33% for ulcerative colitis,and 17% for Crohn's disease,and PPV of high Hb level alone was 18%,25% and 13%,respectively.CONCLUSION:Fecal Lf and Hb were found useful in the detection of colorectal diseases,and the combination of the two measurements appears to increase the sensitivity and efficacy of diagnosis. | Ichiro Hirata Masahiro Hoshimoto Osamu Saito Masanobu Kayazawa Takashi Nishikawa Mitsuyuki Murano Ken Toshina Fang-Yu Wang Ryoichi Matsuse | 2007 | World Journal of Gastroenterology2007，13，10： | 3 |
| 6 | Usefulness of Methemoglobin/Haptoglobin Analysis in the Follow-up of Severe Immune Hemolytic Anemia显示文摘 | Toshio Okazaki Tatsuo Nagai Mitsuyuki Suzuki | 2002 | Chest2002，121，： | 1 |
| 7 | Mechanical thermal synthesis of chro-mium carbides显示文摘 | Osvaldo Mitsuyuki Cintho Eliane Aparecida Peixoto Favilla José Deodoro Trani Capocchi | 2007 | Journal of Alloys and Compounds2007，439，： | 1 |
| 8 | A flow cytometric assay reveals an enhancement of phagocytosis by platelet activating factor in murine peritoneal macrophages 显示文摘 | Mitsuyuki Ichinose Nobumasa Hara Masashi Sawada | 1994 | Cellular Immunology1994，156，： | 1 |
| 9 | Delayedrelease tablets using hydroxyethylcellulose as a gelforming matrix显示文摘 | A Kazuhiko N Chizuko | 1996 | Inter Pharm1996，138，： | 1 |
| 10 | An advanced autofocus for video camera using quasi condition reasoning显示文摘 | KAZUHIGE O KEIJI I MITSUYUKI N | 1990 | IEEE Transactions on Consumer Electronics1990，36，3： | 1 |
| 11 | Cycle analysis of low and high H2 utilization SOFC/gas turbine combined cycle for CO2 recovery显示文摘 | Takuto Araki Takuya Taniuchi Dalsuke Sunakawa Mitsuyuki Nagabama Kazuo Onda Tom Kate | 2007 | Journal of Power Sources2007，171，2007： | 1 |
| 12 | Present status and strategy of NSAIDs-induced small bowel injury显示文摘 | Kazuhide Higuchi Eiji Umegaki Toshio Watanabe Yukiko Yoda Eijiro Morita Mitsuyuki Murano Satoshi Tokioka Tetsuo Arakawa | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 13 | Intraoperative radiotherapy the japanes experience 显示文摘 | | 1981 | Int J Rad Oncology Biol Phys1981，7，： | 1 |
| 14 | Earthquake Early Warning Starts Nationwide in Japan显示文摘 | Mitsuyuki Hoshiba | 2008 | EOS Transactions American :eophysical union2008，89，8： | 1 |
| 15 | External and intraoperative radiotherapy for resectable and unresectable pancreatic cancer: Analysis of survival rates and complications显示文摘 | Yasumasa Nishimura Ryo Hosotani Yuta Shibamoto Masaki Kokubo Shuichi Kanamori Keisuke Sasai Masahiro Hiraoka Gakuji Ohshio Masayuki Imamura Masaji Takahashi Mitsuyuki Abe | 1997 | International Journal of Radiation Oncology, Biology, Physics1997，，1： | 1 |
| 16 | High-dose intraoperative radiotherapy for unresectable pancreatic cancer显示文摘 | Yuta Shibamoto Tadao Manabe Gakuji Ohshio Keisuke Sasai Yasumasa Nishimura Masayuki Imamura Masaji Takahashi Mitsuyuki Abe | 1995 | International Journal of Radiation Oncology, Biology, Physics1995，，1： | 1 |
| 17 | Effects of second phase morphology on retained austenite morphology and tensile properties in a TRIP-aided dual-phase steel sheet 显示文摘 | Sugitomo Koh-ichi Misu Masahiro Kobayashi Mitsuyuki et al | 1993 | Iron and Steel Institute of Japan1993，33，7： | 1 |
| 18 | Corrigendum to “Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor” [Biochem. Biophys. Res. Commun. 326 (2005) 744–751]显示文摘 | Takatoshi Soga Takahide Ohishi Tetsuo Matsui Tetsu Saito Mitsuyuki Matsumoto Jun Takasaki Shun-ichiro Matsumoto Masazumi Kamohara Hideki Hiyama Shigeru Yoshida Kazuhiro Momose Yoshitaka Ueda Hitoshi Matsushime Masato Kobori Kiyoshi Furuichi | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 1 |
| 19 | Characterization of hetero junctions in crystalline-silicon-based solar cells by internal photoemission 显示文摘 | ISAO S MITSUYUKI Y HITOSHI K | 2009 | Sol Energy Mater Sol Ceils2009，93，67： | 1 |
| 20 | Influence of dry and wet grinding conditions on fineness and shape of particle size distribution of product in a ball mill显示文摘 | NAOYA K MITSUYUKI K SHINICHI K | 2011 | Advanced powder technology2011，，22： | 1 |
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