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108篇 您的检索式:作者名="Miyoshi F"
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1Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information.Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo 2014World Journal of Biological Chemistry2014,5,2:7
2GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells 显示文摘Miyoshi T Otsuka F Shimasaki S 2013Biochem Biophys Res Commun2013,434,2:1
3Mutual regu-lation of follicle-stimulating hormone signaling andbone morphogenetic protein system in humangranulosa cells 显示文摘Miyoshi T Otsuka F Suzuki J 2006Biol Reprod2006,74,6:1
4Generation of Rx +/Pax6 + neural retinal precursors from embryonic stem cells 显示文摘Ikeda H Osakada F Watanabe K Mizuseki K Haraguchi T Miyoshi H 2005Proc Natl Acad Sci USA2005,102,11:1
5Prolonged paced QRS duration as a predict or for congestive heart failure in patients with fight ventrieular apical pacing显示文摘Miyoshi F Kobayashi Y Itou H 2005PACE2005,28,11:1
6Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitarycorticotrope cells:involvement of up-regulation of BMP receptor signaling by somatostatin analogs显示文摘Tsukamoto N Otsuka F Miyoshi T 2010Endocrinology2010,151,3:1
7High temperature strength and inelastic behavior of plate-fin structures for HTGR 显示文摘Kawashima F Igari T Miyoshi Y 2007Nuclear Engineering and Design2007,237,6:1
8Cardiomyocytes can be generated from marrow stromal cells in vitro 显示文摘Makino S Fukuda K Miyoshi S Konishi F Kodama H Pan J Sano M Takahashi T Hori S Abe H Hata J Umezawa A Ogawa S 1999J Clin Invest1999,103,:1
9Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector显示文摘MIYOSHI H TAKAHASHI M GAGE F H 1997Proc Natl Acad Sci USA1997,94,10:1
10Role of oxida- tive stress in germ cell apoptosis induced by di(2-eth- ylhexyl) phthalate 显示文摘Kasahara E Sato E F Miyoshi M 2002Biochemical Journal2002,365,3:1
11Identification and character- ization of the murine TRPMg channel 显示文摘Murakami M Xu F Miyoshi I 2003Biochem Biophys Res Commun2003,307,:1
12Prolonged paced QRS duration as a predictor for congestive heart failure in patients with right ventricular apical pacing显示文摘Miyoshi F Kobayashi Y ltou H 2005PACE2005,28,11:1
13Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector 显示文摘Miyoshi H Takshashi M Gage F H 1997Proc Natl Acad Sci USA1997,94,10:1
14Interference by plastics additives in the HPLC determination of microcystin-LR and-YR 显示文摘Miyoshi Ikawa Nancy Phillips James F Haney 1999Toxicon1999,37,:1
15Near-ultraviolet femtosecond laser ionization of dioxins in gas chromatography/time-of-flight mass spectrometry显示文摘YAMAGUCHI S KIRA F MIYOSHI Y 0,,:1
16Activation of be- ta-eatenin signaling in differentiated mammary secretory cells in- duces transdifferentiation into epidermis and squamous metaplasias 显示文摘Miyoshi K Shillingford J M Le Provost F 2002Proc Natl Acad Sei USA2002,99,1:1
17Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitary corticotrope ceils: involvement of up-regulation of BMP receptor signaling by somatostatin analogs 显示文摘Tsukamoto N Otsuka F Miyoshi T 2010Endocrinology2010,151,3:1
18Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector显示文摘Miyoshi H Takshashi M Gage F H 1997Proc Natl Acad Sci USA1997,94,10:1
19Bronehopulmonary dysplasia显示文摘Monte L F Silva F L V Miyoshi M H 2005J Pediatr2005,81,1:1
20E-cell Simulation System and Its Application to the Modeling of Circadian Rhythm显示文摘Miyoshi F Nakayama Y Tomita M 2003Seikagaku2003,75,1:1
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