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| 1 | ACE and ACE2 in kidney disease显示文摘Renin angiotensin system(RAS) activation has a significant influence on renal disease progression. The classical angiotensin-converting enzyme(ACE)-angiotensin Ⅱ(Ang Ⅱ)-Ang Ⅱ type 1(AT1) axis is considered to control the effects of RAS activation on renal disease.However, since its discovery in 2000 ACE2 has also been demonstrated to have a significant impact on the RAS.The synthesis and catabolism of Ang Ⅱ are regulated via a complex series of interactions, which involve ACE and ACE2. In the kidneys, ACE2 is expressed in the proxima tubules and less strongly in the glomeruli. The synthesisof inactive Ang 1-9 from Ang Ⅰ and the catabolism of Ang Ⅱ to produce Ang 1-7 are the main functions of ACE2. Ang 1-7 reduces vasoconstriction, water retention, salt intake, cell proliferation, and reactive oxygen stress, and also has a renoprotective effect. Thus, in the nonclassical RAS the ACE2-Ang 1-7-Mas axis counteracts the ACE-Ang Ⅱ-AT1 axis. This review examines recent human and animal studies about renal ACE and ACE2. | Sonoo Mizuiri Yasushi Ohashi | 2015 | World Journal of Nephrology2015，4，1： | 15 |
| 2 | CDDP+CPT-11 therapy is useful for stage IVb esophageal small cell carcinoma显示文摘 | Mizuiri H Hihara J Okada M | | 0，，： | 1 |
| 3 | Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls显示文摘 | Mizuiri S Hemmi H Arita M | | 0，，： | 1 |
| 4 | Urinary angiotensin-converting enzyme 2 in patients with CKD显示文摘 | MIZUIRI S AOKI T HEMMI H | 2011 | Nephrology (Carlton)2011，16，6： | 1 |
| 5 | Adult intussusception due to lymphangioma of the colon显示文摘 | Matsuba Y Mizuiri H Murata T | 2003 | J Gastroenterol2003，38，2： | 1 |
| 6 | Adult intussusception due to lymphangioma of the colon显示文摘 | Matsuba Y Mizuiri H Murata T | 2003 | J Gastroenterol2003，38，2： | 1 |
| 7 | Nuclear factor-κB activation in diabetic rat kidney:evidence for involvement of P-selectin in diabetic nephropathy显示文摘 | Iwamoto M Mizuiri S Arita M | 2005 | Tohoku J Exp Med2005，206，2： | 1 |
| 8 | Report of a case with fulminant hepatitis a associated with acute renal failure显示文摘 | Mizuiri K KameyamaM Sagawa Y | 1985 | Gastroenterol Jpn1985，20，5： | 1 |
| 9 | Effects of new peritoneal dialysis solutions, pyridoxamine and ATI receptor blocker, on TGF-betal and VEGF expression in rat peritoneal mesothelial cells 显示文摘 | Mizuiri S Ohashi Y Hemmi H | 2009 | Am J Nephrol2009，30，3： | 1 |
| 10 | Renal ACE immunohistochemical location in NIDDM patients with nephropathy 显示文摘 | Mizuiri S Yoshikawa H Tanegashima M | 1998 | Am J Kidney1998，31，2： | 1 |
| 11 | Nuclear factor-κB activation in diabetic rat kidney: evidence for involvement of P-selectin in diabetic nephropathy 显示文摘 | Iwamoto M Mizuiri S Arita M | 2005 | Tohoku J Exp Med2005，206，： | 1 |
| 12 | Renal involement in POEMS syndrome显示文摘 | Mizuiri S Mitsuo K Sakai K | 1991 | Nephron1991，59，： | 1 |
| 13 | Effects of newperitoneal dialysis solutions,pyridoxamine and AT1 receptorblocker,on TGF-beta1 and VEGF ex pression in rat peritonealmesothelial cells显示文摘 | MIZUIRI S OHASHI Y HEMMI H | 2009 | Am J Nephrol2009，30，3： | 1 |
| 14 | Effects of new peritoneal dialysis solutions,pyridoxamine and AT1 receptor blocker,on TGF-beta1 and VEGF expression in rat peritoneal mesothelial cells显示文摘 | Mizuiri S Ohashi Y Hemmi H | 2009 | Am J Nephrol2009，30，3： | 1 |
| 15 | Angiotensin-converting enzyme polymorphism and develolpment of diabetic nephropathy in non-insulin-dependent diabetes mellitus显示文摘 | Mizuiri S Hemmi H Inoue A | 1995 | Nephron1995，70，4： | 1 |
| 16 | Transient prehypertensive treatment in spontaneously hypertensive rats:A comparison of losartan and amlodipine regarding long-term blood pressure,cardiac and renal protection显示文摘 | Mizuiri S Hemmi H Arita M | 2008 | Am J Kidney Dis2008，51，4： | 1 |
| 17 | Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls显示文摘 | Mizuiri S Hemmi H Arita M | 2008 | Am J Kidney Dis2008，51，4： | 1 |
| 18 | Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls 显示文摘 | Mizuiri S Hemmi H Arita M | 2008 | Am J Kidney Dis2008，51，4： | 1 |
| 19 | Expression of ACEand ACE2 in individuals with diabetic kidney disease and healthycontrols显示文摘 | MIZUIRI S HEMMI H ARITA M | 2008 | American Journal of Kidney Diseases2008，51，4： | 1 |
| 20 | Nuclear factor-kappa B activation in diabetic rat kidney: evidence for involvement of P- selectin in diabetic nephropathy 显示文摘 | Iwamoto M Mizuiri S Arita M | 2005 | Tohoku J Exp Med2005，206，2： | 1 |
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