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| 1 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 2 | Sterotaceic aspiration of putaminal hem orrhange using a double track aspiration technique显示文摘 | Mizuma H Sazuki J | 1998 | Neurosurgery1998，22，4： | 1 |
| 3 | The sex ratio of chicken-quail hy- brids 显示文摘 | Takashima Y Mizuma Y | 1982 | Japanese Poultry Science1982，19，1： | 1 |
| 4 | Intestinal SGLT1- mediated absorption and metabolism of benzyl b-glucoside contained in Prunus mume: cartier-mediated transport increases intestinal availability 显示文摘 | Mizuma T Nakamura M Ina H | 2005 | Biochim Biophys Acta2005，1722，： | 1 |
| 5 | Intestinal absorption of stable cyclic glycylphenylalanine: comparison with the linear form显示文摘 | Mizuma T Masubuchi S Awazu S | 1997 | J Pharm Pharmacol1997，49，11： | 1 |
| 6 | Intestinal absorption of stable cyclic glycylphenylalanine: comparison with the linear form 显示文摘 | Mizuma T Masubuchi S Awazu S | 1997 | J Pharm Pharmacol1997，49，11： | 1 |
| 7 | Cerebral microbleeds on T2*-weighted images and hemorrhagic transformation after antithrombotic therapies for ischemic stroke 显示文摘 | Takahashi W Moriya Y Mizuma A | 2013 | J Stroke Cerebrovasc Dis2013，22，： | 1 |
| 8 | Fluorescence energy transfer study of the relationship between the lone tryptophan residue and drug binding sites in human serum albumin 显示文摘 | KASA1 S HOR1E T MIZUMA T | 1987 | Journal of Pharmaceutical Sciences1987，76，5： | 1 |
| 9 | Digital fault location for parallel double-circuit multi terminal transmission lines显示文摘 | Funabashi T Otoguro H Mizuma Y | 2000 | IEEE Transactions on Power Delivery2000，15，2： | 1 |
| 10 | The Subject about Standardization of the Auto- matic Train Operation Systems 显示文摘 | YAMAGUCHI T MIZUMA T HOSOKAWA NARUYU- KI | 2003 | Nippon Kikai Gakkai Kotsu Butsuryu Bumon Taikai Koen Ronbunshu2003，12，49： | 1 |
| 11 | Thyroid hormone activation in human vascular smcoth muscle cell: expression of type Ⅱ iodothyronine delodinase显示文摘 | Mizuma H Murakami M Mort M | 2001 | Cire Res2001，88，3： | 1 |
| 12 | Cerebral mierobleeds on T2 * -weighted images and hemorrhagic transformation after antithrom- bolytie therapies for ischemic stroke 显示文摘 | Takahashi W Moriya Y Mizuma A | 2013 | J Stroke Cerebrovase Dis2013，22，8： | 1 |
| 13 | Distribution of Storage Proteins in Low-Glutelin Rice Seed Determined Using a Fluorescent Antibody显示文摘 | Sachiko F Mizuma T Kiyokawa Y | 2003 | Journal of Bioseienee and Bioengi neering2003，96，5： | 1 |
| 14 | Precedence of the shift of body-fat distribution over the change in body composition after menopause显示文摘 | Morita Y Iwamoto I Mizuma N | 2006 | J Obstet Gynaecol Res2006，32，5： | 1 |
| 15 | Cerebral microb- leeds on T2 -weighted images and hemorrhagic transforma- tion after antithrombotic therapies for ischemic stroke显示文摘 | Takahashi W Moriya Y Mizuma A | 2013 | J Stroke Cerebrovasc Dis2013，22，8： | 1 |
| 16 | Characterization by restriction fragment length polymorphism and sequence analysis of field and vaccine strains of infectious laryngotracheitis virus involved in severe outbreaks显示文摘 | Chacon J L Mizuma M Y Piantino F A | 2010 | Avian Pathol2010，39，6： | 1 |
| 17 | Perioperative rehabilitationapproaches in those over 75 years with respiratory dysfunction fromchronic obstructive pulmonary disease undergoing abdominal tumorsurgery显示文摘 | Kii Y Mizuma M Kawate N | 2012 | Disabil Rehabil2012，34，2： | 1 |
| 18 | Precedence of theshift of body-fat distribution over the change in body compo-sition after menopause 显示文摘 | Morita Y Lwamoto I Mizuma N | 2006 | J Obstet Gynaecol Res2006，32，： | 1 |
| 19 | Evaluation of sit-to-stand motion using a pressure distribution measurement system- effect of differences in seat hardness on sit-to-stand motion显示文摘 | Sato S Mizuma M Kawate N | | 0，，04： | 1 |
| 20 | Systemic administration of polymeric nanoparticle-encapsulated curcumin(NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer显示文摘 | Bisht S Mizuma M Feldmann G | 2010 | Mol Cancer Ther2010，9，8： | 1 |
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