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| 1 | Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs显示文摘AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious dogs.METHODS:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist administration.The force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and colon.Test materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive state.The effects of these receptor antagonists on normal gastrointestinal motor activity were analyzed.RESULTS:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal ileum.The 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor activity.In the proximal colon,the inhibitory effect was dose dependent.Dose dependency,however,was not observed in the distal colon.The 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.CONCLUSION:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity.The5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. | Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii Tetsuro Ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis显示文摘AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing hyperthermochemotherapy.METHODS Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in vitro.CONCLUSION The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies. | Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro Yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai Hiroyuki Kuwano | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 3 | Evaluation of 18F-2-deoxy-2-fluoro-d-glucose Positron Emission Tomography for Gastric Cancer显示文摘 | Erito Mochiki Hiroyuki Kuwano Hiroyuki Katoh Takayuki Asao Noboru Oriuchi Keigo Endo | 2004 | World Journal of Surgery2004，，3： | 2 |
| 4 | Laparoscopically assisted total gastrectomy with lymph node dissection for upper and middle gastric cancer显示文摘 | Erito Mochiki Yoshitaka Toyomasu Kyouichi Ogata Hiroyuki Andoh Tetsuro Ohno Ryusuke Aihara Takayuki Asao Hiroyuki Kuwano | 2008 | Surgical Endoscopy2008，，9： | 2 |
| 5 | Relationship between clinicopathological features and mucin phenotypes of advanced gastric adenocarcinoma显示文摘AIM: To investigate a relationship between the clinicopathological features and mucin phenotypes in advanced gastric adenocarcinoma (AGA). METHODS: Immunohistochemical staining was performed to determine the mucin phenotypes in 38 patients with differentiated adenocarcinomas (DACs), 9 with signet-ring cell carcinomas (SIGs), and 48 with other diffuse-type adenocarcinomas (non-SIGs) of AGA. The mucin phenotypes were classified into 4 types: gastric (G), gastrointestinal (GI), intestinal, and unclassified. RESULTS: The G-related mucin phenotypes were highly expressed in all the histological subtypes of AGA. The expression of the GI phenotype in SIG patients was lower than that in DAC patients (P = 0.02), and this phenotype was observed in 56% of the non-SIG patients in the intramucosal layer. Among non-SIG cases, the expression of the GI phenotype was significantly higherin patients with extended adenocarcinomas and those with positive rates of lymph node metastasis. There was no difference between the expressions of the G and other GI phenotypes factors. Among DAC and non-SIG patients, there were no differences between the survival rates of the corresponding patient groups. CONCLUSION: The GI phenotype might possess more invasive characteristics than the G phenotype in nonSIG. Neither of the phenotypes indicated a poor prognosis of DAC and non-SIG. | Fumiaki Toki Atsushi Takahashi Ryusuke Aihara Kyoichi Ogata Hiroyuki Ando Tetsuro Ohno Erito Mochiki Hiroyuki Kuwano | 2010 | World Journal of Gastroenterology2010，16，22： | 2 |
| 6 | Laparoscopic assisted distal gastrectomy for early gastric cancer:five years'experience显示文摘 | Mochiki E Kamiyama Y Aihara R | | 0，，03： | 2 |
| 7 | Laparoscopically assisted total gastrectomy with lymph node dissection for upper and middle gastric cancer显示文摘 | Mochiki E Toyomasu Y Cogata K | | 0，，09： | 1 |
| 8 | The roles of motilin and ghrelin in gastrointestinal motility显示文摘 | Ohno T Mochiki E Kuwano H | 2010 | Int J Pept2010，2010，82： | 1 |
| 9 | Evaluation of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography for gastric cancer 显示文摘 | Mochiki E Kuwano H Katoh H | 2004 | World J Surg2004，28，3： | 1 |
| 10 | Sentinel lymph node mapping with technetium99m colloidal rhenium sulfide in patients with gastric carcinoma显示文摘 | Mochiki E Kuwano H Kamiyama Y | 2006 | Am J Surg2006，191，： | 1 |
| 11 | Laparoscopic assisted distal gastrec-tomy for early gastric cancer: five years'experience 显示文摘 | Mochiki EV Kamiyama Y Aihara R | 2005 | Surgery2005，137，3： | 1 |
| 12 | Evaluation of 18F -2 -deoxy - 2 - fluoro - D - glucose positron emission tomography forgastric cancer显示文摘 | Mochiki E Kuwano H Katoch H | 2004 | World J Surg2004，28，3： | 1 |
| 13 | {;astroinlstinal recovery and outcome after laparoscopy-assisted versus conventional open distal gastrectomy fir early gastric cancer显示文摘 | Mochiki E Nakabayashi T Kamimura H | 2002 | Wrht J Surg2002，26，9： | 1 |
| 14 | Gastrointestinal stromal tumor of the stomach:report of a case显示文摘 | Kamimura H Mochiki E Kamiyama Y | 2005 | Hepatogastroenterology2005，52，64： | 1 |
| 15 | Gastropyloric motor activity and the effects of erythromycin given orally after esophagectomy显示文摘 | Nakabayashi T Mochiki E Garcia M | 2002 | Am J Surg2002，183，3： | 1 |
| 16 | Laparoscopic assisted distal gastrectomy for early gastric cancer: Five years' experience 显示文摘 | Mochiki E Kamiyama Y Aihara R | 2005 | Surgery2005，137，： | 1 |
| 17 | Laparoscopically assisted total gastrectomy with lymph node dissection for upper and middle gastric cancer 显示文摘 | Mochiki E Toyomasu Y Ogata K | 2008 | Surg Endosc2008，22，9： | 1 |
| 18 | Laparoscopically assisted total gastrectomy with lymph node dissection for upper and middle gastric cancer显示文摘 | Erito Mochiki Yoshitaka Toyomasu Kyouichi Ogata Hiroyuki Andoh Tetsuro Ohno Ryusuke Aihara Takayuki Asao Hiroyuki Kuwano | 2008 | Surgical Endoscopy2008，，9： | 1 |
| 19 | Evaluation of 18 F-2-deoxy-2-fluoro-D-glucose positron emission tomography for gastric cancer显示文摘 | Mochiki E Kuwano H Katoh H | 2004 | World J Surg2004，28，3： | 1 |
| 20 | Relationship between intraduodenal 5 - hydroxytryptamine release and interdigestive contractions in dogs 显示文摘 | Tanaka T Mizumoto A Mochiki E | 2004 | J Smooth Muscle Res2004，40，3： | 1 |
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