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| 1 | A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures显示文摘以前的调查后退幸存由神经生长因素(NGF ) 和另外的 neurotrophins 发信号支持了多样的机制,但是所有建议机制有在普通 retrogradely 传给 neuronal 细胞身体的幸存信号的产生。我们报导在轴突发现被本地 NGF 发信号压制一个 retrograde apoptotic 信号。从远侧的轴突的 NGF 退却独自是足够的激活 pro-apoptotic 抄写因素, c-jun,在房间身体。直接提供 NGF 给房间身体,从而恢复导致 NGF 的幸存的来源发信号,不能阻止 NGF 退却从远侧的轴突引起的 c-jun 激活。这是 c-jun 没在房间身体由于幸存信号的损失被激活的证据。而且,与用番红花作原料而制成的植物盐基堵住 axonal 运输禁止了建议 retrogradely 搬运的幸存的一个 retrogradely 搬运的 pro-apoptotic 信号,而非损失发信号的 NGF 剥夺引起的 c-jun 激活,引起的 c-jun 激活。另外的实验证明 c-jun, pro-caspase-3 劈开,和 apoptosis 的激活被蛋白质 kinase C 禁止者, rottlerin 和 chelerythrine 堵住,仅仅当适用于建议他们堵住轴突特定的 pro-apoptotic 信号的远侧的轴突时。rottlerin 敏感的机制被发现调整肝糖 synthase kinase 3 (GSK3 ) 活动。siRNA 的效果击倒,并且 GSK3 的药理学抑制建议 GSK3 为 NGF 剥夺引起的 apoptosis 被要求并且可以作为轴突 apoptotic 信号的一个 retrograde 搬运人工作。在被 neurotrophins 压制的轴突表明系统的 retrograde 死亡的存在为 neurodevelopment 并且为为 neurodegenerative 疾病和 neurotrauma 发现治疗有宽广含意。 | Sue-Ann Mok Karen Lund Robert B Campenot | 2009 | Cell Research2009，19，5： | 2 |
| 2 | Modulation of chaperone function and cochaperone interaction by novobiocin in the C- terminal domain of Hsp90 evidence that coumarin antibiotics disrupt Hsp90 dimerization显示文摘 | Allan R K Mok D Ward B K | 2006 | The Journal of Biology Chemistry2006，281，11： | 1 |
| 3 | Cancer of the stomach:a review of two hospitals in Korea and Japan显示文摘 | Mok Y J Koo B W Whang C W | 1993 | World J Surg1993，17，6： | 1 |
| 4 | Understanding Rasch measurement:Rasch models overview显示文摘 | Wright B D Mok M | 2000 | Journal of Applied Measure- ment2000，，1： | 1 |
| 5 | Interventional radiology in women with suspected placenta accreta undergoing caesarean section 显示文摘 | Mok M Heidemann B Dundas K | 2008 | Int J Obstet Anesth2008，17，3： | 1 |
| 6 | Liver resection af teririnotecan, 52 fluorouraci and folinic acid for patient swith unreseetable colorectal livermetastases : amuhieenter phase II study by the Caneer Therapeutic Research Group显示文摘 | Ho WM Ma B Mok T | 2005 | Med 0nco2005，22，3： | 1 |
| 7 | Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontln fragments for ovarian cancer in urine 显示文摘 | Ye B Skates S Mok SC | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 8 | Analysis of torque ripple in BLDC motor with commutation time 显示文摘 | Kang B H Kim C J Mok H S etal | 2001 | IEEE International Symposium on Industrial Electronics2001，，： | 1 |
| 9 | Protein profiling of complete mole and normal placenta using proteinchip analysis on laser capture microdis-sected cells显示文摘 | Batorfi J Ye B Mok SC | 2003 | Gynecologic Oncology2003，88，： | 1 |
| 10 | Interventional radiology in women with suspected placenta accreta undergoing caesarean section 显示文摘 | Mok M Heidemann B Dundas K | 2008 | International Journal of Obstetric Anesthesia2008，17，3： | 1 |
| 11 | rpS6 Regulates blood-testis barrier dynamics by affecting F -actin organization and protein recruitment显示文摘 | Mok KW Mruk DD Silvestrini B | 2012 | Endocrinology2012，153，10： | 1 |
| 12 | Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine显示文摘 | Ye B Skates S Mok SC | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 13 | Recent technical strategies to identify diagnostic biomarkers for ovarian cancer显示文摘 | Ye B Gagnon A Mok SC | 2007 | Expert Rev Pro-teomics2007，4，1： | 1 |
| 14 | Intensity modulated radia- tion therapy(IMRT) : differences in target volumes and improve- ment in clinically relevant doses to small bowel in rectal carcinoma 显示文摘 | Mok H Crane C H Palmer M B | 2011 | Radiat Oncol2011，6，： | 1 |
| 15 | Low erythrocyte complement receptor type 1 (CR1, CD35) expression in preeclamptic gestations 显示文摘 | FEINBERG B B JACK R M MOK S C | 2005 | Am J Reprod Immunol2005，54，6： | 1 |
| 16 | Recent technical strategies to identify di- agnostic biomarkers for ovarian cancer显示文摘 | Ye B Gag~on A Mok SC | 2007 | Expert Rev Proteomies2007，4，1： | 1 |
| 17 | New technologies for the identification of marhers for early detection of ovarian cancer 显示文摘 | Bandera CA Ye B Mok S C | 2003 | Curt Opin Obstet Gynecol2003，15，1： | 1 |
| 18 | A single nucleotide polymorphism in proteintyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Gree显示文摘 | Mok A Cao H Zinman B | 2002 | J Clin Endocrinol Metab2002，87，2： | 1 |
| 19 | Thiol-directed immobilization of recombinant IgG-binding receptors显示文摘 | Ljungquist C jansson B Moks T | 1989 | Eur J Biochem1989，186，： | 1 |
| 20 | Interventional radiology in women with suspected placenta accreta undergoing caesarean section显示文摘 | Mok M Heidemann B Dundas K | | 0，，3： | 1 |
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