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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Sesmic Isolation Retrofit of Large Historic Buildings显示文摘 | Mokha A S Amin N Constantinou M C | 1996 | Journal of structure engineering ASCE1996，122，3： | 1 |
| 3 | Seismic isolation retrofit of large historic building显示文摘 | Mokha A S Amin N Constantinou M C Zayas V | 1996 | Journal of Structural Engineering ASCE1996，122，3： | 1 |
| 4 | Nociceptin( orphanin FQ), an endogenous ligand for the QRL1 (opioid - receptor - llkel) receptor, modulates responses of trigeminal neurons evoked by excitatory amino acids and somatoseusory stimuli 显示文摘 | Wang XM Zhang KM Mokha SS | 1996 | J Neurophysiol1996，76，： | 1 |
| 5 | Experimental study of friction pendulum system isolation system显示文摘 | Mokha A S Constantinou M C Reinhorn A M Zayas V | 1991 | Journal of Structural Engineering ASCE1991，117，4： | 1 |
| 6 | Teflon Bearings in Base Isolation I:Testing显示文摘 | Mokha A Constantinou M Reihom A M | 1990 | Journal of Structural Engineering ASCE1990，116，2： | 1 |
| 7 | Experimental study of friction pendulum isolation system显示文摘 | Mokha A Constantinou M C Reinhorn A M | 1991 | Journal of Structural Engineering ASCE1991，117，4： | 1 |
| 8 | Pathways mediating descending control of spinal nociceptive transmission from the nuclei locus coeruleus (LC) and raphe magnus (NRM) in the cat显示文摘 | S. S. Mokha J. A. McMillan A. Iggo | 1986 | Experimental Brain Research1986，，3： | 1 |
| 9 | Teflon Bearings in Base Isolation Ⅱ:Modeling显示文摘 | Constantinou M Mokha A Reinhorn A | 1990 | Journal of Structural Engineering ASCE1990，116，2： | 1 |
| 10 | Ⅱ:modeling显示文摘 | Michalakis Constantinou Anoop Mokha Andrei Re-inhorn Teflon bearings in base isolation | 1990 | Journal of Structural Engineering1990，116，2： | 1 |
| 11 | Sesmic Isolation Retrofit of Large Historic Buildings 显示文摘 | Mokha A S Amin N Constantinou M C Zayas V | 1996 | Journal of Structure Engineering ASCE1996，122，3： | 1 |
| 12 | Experimental study of friction pendulum isolation system显示文摘 | Mokha A S | 1991 | Jornal of Structural Engineering ASCE1991，117，4： | 1 |
| 13 | Experimental Study of Friction Pendulum System Isolation System显示文摘 | Mokha A S Constantinou M C Reinhom A M Zayas V | 1991 | Journal of Structure Engineering ASCE1991，117，12： | 1 |
| 14 | Teflon beatings in base isolation(Ⅰ): testing显示文摘 | MOKHA A CONSTANTINOU M REINHORN A | 1990 | Journal of Structural Engineering1990，116，2： | 1 |
| 15 | Seismic isolation retrofit of large historic building 显示文摘 | Mokha A S Amin N Constantinou M C Zayas V | 1996 | Journal of Structural Engineering ASCE1996，122，3： | 1 |
| 16 | Utility of waist-to-height ratio in assessing the status of central obesity and relatedcardiometabolic risk profile among normal weight and overweight/obesechildren: the Bogalusa Heart Study 显示文摘 | Mokha JS Srinivasan SR Dasmahapatra P | 2010 | BMC Pediatr2010，10，： | 1 |
| 17 | Experimental study of friction pendulum system isolation system 显示文摘 | Mokha A S Constantinou M C Reinhorn A M Zayas V | 1991 | Journal of Structural Engineering ASCE1991，117，4： | 1 |
| 18 | Utility of waist-to-height ratio in assessing the status of central obesity and related cardiometabolic risk profile among normal weight and overweight/obese children:the Bogalusa Heart Study显示文摘 | Mokha JS Srinivasan SR Dasmahapatra P Fernandez C Chen W Xu J | | 0，，： | 1 |
| 19 | Seismic isolation retrofit of large historic buildings 显示文摘 | Mokha A S Amin N Constantinou M C Zayas V | 1996 | Journal of Structure Engineering ASCE1996，122，3： | 1 |
| 20 | Nociceptin (Orphanin FQ), an endogenous ligand for the ORL1 (Opioid-Receptor-Like1) receptor, modulates resp onses of trigeminal neurons evoked by excitatory amino acids and somatosensory s timuli显示文摘 | Zhang KM, Mokha SS | 1996 | J Neurophysiol1996，76，： | 1 |
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