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| 1 | Metastatic tumors to the pancreas: The role of surgery显示文摘Pancreatic metastases from other primary malignancies are a rare entity. By far, the most common primary cancer site resulting in an isolated pancreatic metastasis is the kidney, followed by colorectal cancer, melanoma, breast cancer, lung carcinoma and sarcoma. Only few data on the surgical outcome of pancreatic resections performed for metastases from other primary tumor have been published, and there are no guidelines to address the surgical treatment for these patients. In this study, we performed a review of the published literature, focusing on the early and long-term results of surgery for the most frequent primary tumors metastasizing to the pancreas. Results for the Literature's analysis show that in last years an increasing number of surgical resections have been performed in selected patients with limited pancreatic disease. Pancreatic resection for metastatic disease can be performed with acceptable mortality and morbidity rates. The usefulness of pancreatic resection is mainly linked to the biology of the primary tumor metastasizing to the pancreas. The benefit of metastasectomy in terms of patient survival has been observed for metastases from renal cell cancer, while for other primary tumors, such as lung and breast cancers, the role of surgery is mainly palliative. | Cosimo Sperti Lucia Moletta Giuseppe Patanè | 2014 | World Journal of Gastrointestinal Oncology2014，6，10： | 8 |
| 2 | Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer显示文摘AIM To analyze the importance of para-aortic node status in a series of patients who underwent pancreaticoduodenectomy(PD)in a single Institution.METHODS Between January 2000 and December 2012,151patients underwent PD with para-aortic node dissection for pancreatic adenocarcinoma in our Institution.Patients were divided into two groups:patients with negative PALNs(PALNs-),and patients with metastatic PALNs(PALNs+).Pathologic factors,including stage,nodal status,number of positive nodes and lymph node ratio,invasion of para-aortic nodes,tumor’s grading,and radicality of resection were studied by univariate and multivariate analysis.Survival curves were constructed with Kaplan-Meier method and compared with Log-rank test:significance was considered as P<0.05.RESULTS A total of 107 patients(74%)had nodal metastases.Median number of pathologically assessed lymph nodes was 26(range 14-63).Twenty-five patients(16.5%) had para-aortic lymph node involvement.Thirty-three patients(23%)underwent R1 pancreatic resection.Onehundred forty-one patients recurred and died for tumor recurrence,one is alive with recurrence,and 9 are alive and free of disease.Overall survival was significantly influenced by grading(P=0.0001),radicality of resection(P=0.001),stage(P=0.03),lymph node status(P=0.04),para-aortic nodes metastases(P=0.02).Multivariate analysis showed that grading was an independent prognostic factor for overall survival(P=0.0001),while grading(P=0.0001)and radicality of resection(P=0.01)were prognostic parameters for disease-free survival.Number of metastatic nodes,node ratio,and para-aortic nodes involvement were not independent predictors of disease-free and overall survival.CONCLUSION In this experience,lymph node status and para-aortic node metastases were associated with poor survival at univariate analysis,but they were not independent prognostic factors. | Cosimo Sperti Mario Gruppo Stella Blandamura Michele Valmasoni Gioia Pozza Nicola Passuello Valentina Beltrame Lucia Moletta | 2017 | World Journal of Gastroenterology2017，23，24： | 5 |
| 3 | Pancreatic resection in very elderly patients:A critical analysis of existing evidence显示文摘The aging of the population results in a rise of number of elderly patients(aged 80 years and older) with pancreatic or periampullary cancer, and more pancreatectomies could eventually be performed in such complex patients. However, early and long-term results after pancreatic resection in octogenarians are still controversial, and may trouble the surgeon when approaching this type of population. Evaluation of reported experiences shows that for almost all Authors, pancreatectomy can be performed safely in elderly population, although overall morbidity and mortality rates were 34.9% and 13.2% respectively, with a mean length of hospital stay of 18 d. These features appear higher in older patients compared to the younger counterpart. Less than 50% of patients underwent adjuvant therapy after operation. Long-term survival is reported not significantly different in aged 80 years and older patients, with a median overall survival time of 17.6 mo. The quality of life after pancreatic resection is only sporadically evaluated but, when considered, it highlights the need of health facility service after operation for these 'frail' patients. Prospective studies on the quality of life of pancreatectomized octogenarians are welcome. Proper selection of patients, geriatric assessment with multidisciplinary approach, centralization of pancreatic surgery in high-volume centres and rehabilitation programs after surgery appear to be crucial points in order to improve surgical treatments of pancreatic tumors in very elderly patients. | Cosimo Sperti Lucia Moletta Gioia Pozza | 2017 | World Journal of Gastrointestinal Oncology2017，9，1： | 2 |
| 4 | Effects of lignocellulosic degradation products on ethanol fermentations of glucose and xylose by Saccharomyces cerevisiae, Zymomonas mobilis, Pichia stipititis and Candida shehatae显示文摘 | Delgens JP Moletta R Navarro JM | 1996 | Enzyme Microb Technol1996，19，： | 2 |
| 5 | Effect of dissolved oxygen and carbon–nitrogen loads on denitrification by an aerobic consortium显示文摘 | D. Patureau N. Bernet J. P. Delgenès R. Moletta | 2000 | Applied Microbiology and Biotechnology2000，，4： | 2 |
| 6 | Two-phase anaerobic digestion of solid wastesby a multiple liquefaction reactors process显示文摘 | Raynal J Delgenes J P Moletta R | 1998 | Bioresource Technology1998，65，： | 1 |
| 7 | Effect of oxygen on denitrification in continuous chemostat culture withComamonas sp SGLY2显示文摘 | D Patureau N Bernet R Moletta | 1996 | Journal of Industrial Microbiology1996，，2： | 1 |
| 8 | Aerobic granular sludge:A case report显示文摘 | Peng D C Bernet N Moletta R | | 0，，03： | 1 |
| 9 | Treatment of organic pollution in industrial saline wastewater: A literature review显示文摘 | Olivier Lefebvre René Moletta | 2006 | Water Research2006，，20： | 1 |
| 10 | Denitrification by anaerobic sludge in piggery wastewater显示文摘 | Berent N Delgenes N Moletta R | 1996 | Environment Technology1996，17，： | 1 |
| 11 | Biological denitrifying phosphorus removal in SBR: effect of added nitrate concentration and sludge retention time显示文摘 | Merzouki M Bemet N Moletta R | 2001 | Water Sci Technol2001，43，： | 1 |
| 12 | Denitrification in anaerobic digesters:Possibilities and influence of wastewater COD/N-Nox ra- tio 显示文摘 | Akunna J C Bizeau C Moletta R | 1992 | Environmental Technology1992，13，： | 1 |
| 13 | Combinedorganic-carbon and complete nitrogen removal using anaerobic andaerobic upflow filters 显示文摘 | Akunna J Bizeau C Moletta R Bernet N Heduit A | 1994 | Water Science and Technology1994，30，12： | 1 |
| 14 | Use of an industrial effluent as a carbon source for denitrification of a high-strength wastewater 显示文摘 | Bernet N Habouzit F Moletta R | 1996 | Applied Microbiology and B iotechnology1996，46，： | 1 |
| 15 | Bacterial and archaeal 16S rDNA and 16S rRNA dynamics during an acetate crisis in an anaerobic digestor ecosystem 显示文摘 | Delbes C Moletta R Godon J J | 2001 | FEMS Microbiol Ecol2001，35，1： | 1 |
| 16 | Winery wastewater depollution by sequencing batch reactor 显示文摘 | MICHEL T MOLETTA R | 1997 | Wat Res1997，，1： | 1 |
| 17 | Sequencing batch reactor technology Ⅱ 显示文摘 | Delgenes J P Torrijos M Moletta R | 2001 | Wat Sci Tech2001，43，3： | 1 |
| 18 | Alcoholic fermentation of glucose and xylose by Pichia stipitis, Can- dida shehatae, Saccharomyces cerevisiae and Zymomonas mobilis: oxygen requirement as a key factor 显示文摘 | Laplace J M Delgenes J P Moletta R | 1991 | Applied Microbiology and Biotechnology1991，36，2： | 1 |
| 19 | Themal-ehemical pretreatment of amicrobial biomass: influence of sodium hydroxide addition on solubilization and anaerobic biodegradability显示文摘 | PENAUD V DELGENES J P MOLETTA R | 1999 | Enzyme and Microbial Technology1999，25，345： | 1 |
| 20 | Effects of nitrogenoxides and denitrification by Pseudomonas stutzeri on acetotrophicmethanogenesis by Methanosarcina mazei 显示文摘 | Clarens M Bernet N Delgenès J P Moletta R | 1998 | FEMS MicrobiologyEcology1998，25，3： | 1 |
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