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| 1 | Recurrence in node-negative advanced gastric cancer:Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series显示文摘AIM To analyze the clinicopathological characteristics of patients with both node-negative gastric carcinoma and diagnosis of recurrence during follow-up. METHODS We enrolled 41 patients treated with curative gastrectomy for p T2-4 a N0 gastric carcinoma between 1992 and 2010,who developed recurrence(Group 1). We retrospectively selected this group from the prospectively collected database of 4 centers belonging to the Italian Research Group for Gastric Cancer,and compared them with 437 p T2-4 a N0 patients without recurrence(Group 2). We analyzed lymphatic embolization,microvascular infiltration,perineural infiltration,and immunohistochemical determination of p53,Ki67,and HER2 in Group 1 and in a subgroup of Group 2(Group 2 bis) of 41 cases matched with Group 1 according to demographic and pathological characteristics. RESULTS T4 a stage and diffuse histotype were associated with recurrence in the group of p N0 patients. In-depth pathological analysis of two homogenous groups of p N0 patients,with and without recurrence during longterm follow-up(groups 1 and 2 bis),revealed two striking patterns: lymphatic embolization and perineural infiltration(two parameters that pathologists can easily report),and p53 and Ki67,represent significant factors for recurrence.CONCLUSION The reported pathological features should be considered predictive factors for recurrence and could be useful to stratify node-negative gastric cancer patients for adjuvant treatment and tailored follow-up. | Gian Luca Baiocchi Sarah Molfino Carla Baronchelli Simone Giacopuzzi Daniele Marrelli Paolo Morgagni Maria Bencivenga Luca Saragoni Carla Vindigni Nazario Portolani Maristella Botticini Giovanni De Manzoni | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
| 2 | Review:Recent advances in nonlinear control technologies for shape memory alloy actuators显示文摘This paper reviews recent developments in nonlinear control technologies for shape memory alloy (SMA) actuators in robotics and their related applications. SMA possesses large hysteresis, low bandwidth, slow response, and non-linear behavior, which make them difficult to control. The fast response of the SMA actuator mostly depends upon, (1) type of controller, (2) rate of addition and removal of heat, and (3) shape or form of the actuator. Though linear controllers are more desirable than nonlinear ones, the review of literature shows that the results obtained using nonlinear controllers were far better than the former one. Therefore, more emphasis is made on the nonlinear control technologies taking into account the intelligent controllers. Various forms of SMA actuator along with different heating and cooling methods are presented in this review, followed by the nonlinear control methods and the control problems encountered by the researchers. | SREEKUMAR M. SINGAPERUMAL M. NAGARAJAN T. ZOPPI M. MOLFINO R. | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，5： | 2 |
| 3 | Ghrelin:from discovery to cancer cachexia therapy显示文摘 | Molfino A Formiconi A Rossi Fanelli F | 2014 | Curr Opin Clin Nutr Metab Care2014，17，5： | 1 |
| 4 | Precessional forcing of nutricline dy- namics in the equatorial Atlantic 显示文摘 | Molfino B McIntyre A | 1990 | Science1990，249，： | 1 |
| 5 | Forcing of Atlantic equatorial and subpolar millennial cycles by precession 显示文摘 | Mcintyre A Molfino B | 1996 | Science1996，277，： | 1 |
| 6 | Role of aetiology, diabetes,tobacco smoking and hypertension in hepatocellular carcinoma survival 显示文摘 | Raffetti E Portolani N Molfino S | 2015 | Dig Liver Dis2015，47，11： | 1 |
| 7 | Cureent thinking on genetics of chronic obstruct society statement occupational contrihution to burden of airway disease显示文摘 | Molfino AN | 2003 | Am J Respir Crit Med2003，167，1： | 1 |
| 8 | Investigational therapeutics targeting the IL-4/IL-13/STAT -6 pathway for the treatment of asthma 显示文摘 | Oh CK Geba GP Molfino N | 2010 | Eur Respir Rev2010，115，19： | 1 |
| 9 | Oceanographic control of diatom abun- dances and species distributions in surface sediments of the tropi- cal and southeast Atlantic 显示文摘 | Pokras E M Molfino B | 1986 | Marine Micropaleontology1986，10，1： | 1 |
| 10 | Smoking and idiopathic puhnona- ry fibrosis显示文摘 | Oh CK Murray LA Molfino NA | 2012 | Pulm Med2012，，80： | 1 |
| 11 | Informational logic as a tool for automated reasoning显示文摘 | PAOLA FORCHERI PAOPO GENTILINI MARIA TERESA MOLFINO | 1998 | Journal of Automated Reasoning1998，20，： | 1 |
| 12 | Investigational thera- peutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma显示文摘 | OH C K GEBA G P MOLFINO N | 2010 | Eur Respir Rev2010，19，115： | 1 |
| 13 | Activity theory:A framework for de-sign and reporting on research projects based on ICT显示文摘 | Rosa-Maria Bottino Giancarlo Chiappini Paola Forcheri EnricaLemut and Maria-Teresa Molfino | 1999 | Education andInformation Technologies1999，，3： | 1 |
| 14 | Metabolic effects of glutamine on insulin sensetvity显示文摘 | MOLFINO A | 2010 | Nutritional Therapy and Metabolism2010，28，1： | 1 |
| 15 | Fixture layout optimization for flexible aerospace parts based on self-reconfigurable swarm intelligent fixture system 显示文摘 | Li X Molfino R Zoppi M | 2013 | International Journal of Machine Tools & Manufacture2013，66，9： | 1 |
| 16 | Gene-environment interactions in chronic obstructive pulmonary disease显示文摘 | Molfino NA Coyle AJ | 2008 | IntJ Chron Obstruct Pulmon Dis2008，3，3： | 1 |
| 17 | Safety design of a petrol pump attendant robot显示文摘 | Francesco Becchi Rezia M. Molfino Roberto P. Razzoli | 2005 | Industrial Robot: An International Journal2005，，5： | 1 |
| 18 | SARA: A Robotic System For Cars Fuelling显示文摘 | F. Becchi R. C. Michelini R. M. Molfino R. P. Razzoli | 2001 | Journal of Intelligent and Robotic Systems2001，，1： | 1 |
| 19 | A meta-analysis on the efficacy of oral theophylline in patients with stable COPD显示文摘 | Molfino NA Zhang P | 2006 | Int J Chron Obstruct Pulmon Dis2006，1，3： | 1 |
| 20 | Gene-environment interactions in chronic obstructive pulmonary disease显示文摘 | Molfino NA Coyle AJ | 2008 | Int J Chron Obstruct Pulmon Dis2008，3，： | 1 |
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