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| 1 | Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review显示文摘AIM:To report our experience with long-term outcomes after multimodal management therapy.METHODS:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to 2011.Demographic,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed.RESULTS:The median age at surgery was 14.4 mo,with a male to female ratio of 4:3.Pretext staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 case.Mean pretreatment tumor volume was 735 cm3.Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols.Tumor volume and alphafetoprotein levels significantly dropped after neoadjuvant therapy.Surgical procedures performed included hemihepatectomies,segmentectomies and atypical resection.All patients received chemotherapy after surgery.Median postoperative hospital stay was 8 d.All patients were alive and disease-free after a median follow-up period of 23 mo.With regards to the literature review,seventeen articles were found that were related to our search.CONCLUSION:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results. | Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado | 2014 | World Journal of Gastroenterology2014，20，29： | 12 |
| 2 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Neurobiology of the response:contribution of the sympathetic nervous system to the neuroimmune axisin traumatic injury显示文摘 | Molina PE | 2005 | Shock2005，24，： | 1 |
| 5 | Differential tissue regulation of insulin-like growth factor-I content and binding proteins after en- dotoxin显示文摘 | Fan J Molina PE Gelato MC | 1994 | Endocrinology1994，134，4： | 1 |
| 6 | Early organ specific hemorrhage induced increase in tissue cytokine content: associated neurohormonal and opioid alterations显示文摘 | MOLINA PE MALEK S LANG CH | 1997 | Neuroimmunomodulation1997，4，1： | 1 |
| 7 | Neurobiology of the response:contribution of the sympathetic nervous system to the neuroimmune axisin traumatic injury显示文摘 | Molina PE | 2005 | Shock2005，24，： | 1 |
| 8 | Angiotensin (1-7) contributes to nitric oxide tonic inhibition of vasopressin release du- ring hemorrhagic shock in acute ethanol intoxicated rodents 显示文摘 | Whitaker AM Molina PE | 2013 | Life Sci2013，93，17： | 1 |
| 9 | Central acetylcholinesterase inhibition improves hemodynamic counterregulation to severe blood loss in alcohol-intoxicated rats显示文摘 | Mathis KW Molina PE | 2009 | Am J Physiol Regul Integr Comp Physiol2009，297，2： | 1 |
| 10 | Push-enteroscopyseries:diagnostic and therapeutic efficacy显示文摘 | Molina PE Lamas G Perez Cuadrado ME | 2002 | Gastrointest Endosc2002，9，3： | 1 |
| 11 | Pushenter oscopyseries: diagnostic and therapeutic efficacy显示文摘 | Molina PE Lamas G Perez Cuadrado ME | 2002 | Gastrointest Endose2002，9，3： | 1 |
| 12 | Consequences of al- cohol - induced early dysregulation of responses to trauma/hem- orrhage 显示文摘 | Molina PE Zambell KL Norenberg K | 2004 | Alcohol2004，33，3： | 1 |
| 13 | Neurobiology of the response: contribution of the sympathetic nervous system to the neuroimmune axis in traumatic injury显示文摘 | Molina PE | 2005 | Shoek2005，24，： | 1 |
| 14 | Reduced RhoA activity mediates acute alcohol intoxication-induced inhibition of lymphatic myogenic constriction despite increased cytosolic[Ca2+]显示文摘 | Souza-Smith FM Molina PE Breslin JW | | 0，，05： | 1 |
| 15 | Central acetylcholinesterase inhibition im- proves hemodynamic counter regulation to severe blood loss in al- cohol- intoxicated rats 显示文摘 | Mathis KW Molina PE | 2009 | Am J Physiol Regul Integr Comp Physiol2009，297，2： | 1 |
| 16 | Neurobiology of the stress response: contribution of the sympathetic nervous system to the neuroimmune axis in traumatic iniury 显示文摘 | Molina PE | 2005 | Shock2005，24，1： | 1 |
| 17 | Neurobiology of the response:contribution of the sympa- thetic nervous system to the neuroimmune axis in traumatic injury 显示文摘 | Molina PE | 2005 | Shock2005，24，1： | 1 |
| 18 | Molecular pathology and clinical aspects of alcohol-induced tissue injury显示文摘 | Molina PE McClain C Valla D | 2002 | Alcohol Clin Exp Res2002，26，： | 1 |
| 19 | Push-enteroscopy series:dignostic and therapeutic efficacy显示文摘 | Molina PE Lamas G Perez-Cuadrado ME | 2002 | Gastrointest Endosc2002，9，3： | 1 |
| 20 | CNI-1443 attenuates hemodynamic and pro-inflammatory responses to LPS显示文摘 | Molina PE Qiun L Schuhlein D | 1998 | Shock1998，10，： | 1 |
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