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| 1 | Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study显示文摘AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer(CRC) at multiple Japanese institutions.METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group's department of gastroenterological surgery. Among them, 234 patients with stage Ⅱ/Ⅲ disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASAPS(HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/d L(HR = 2.96, P = 0.007), T4 tumor(HR = 2.73, P = 0.002) and R1 resection(HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers(HR = 6.28, P = 0.009), a T4 tumor(HR = 3.46, P = 0.011) and R1 resection(HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. | Ishibe Atsushi Ota Mitsuyoshi Yamaguchi Kazuya Kaida Syuhei Kamiya Noriyuki Momiyama Masashi Watanabe Akira Sekizawa Kentaro Kamimukai Nobuyuki Sugimasa Natsuko Watanabe Jun Ichikawa Yasushi Kunisaki Chikara Endo Itaru | 2016 | World Journal of Gastroenterology2016，22，22： | 9 |
| 2 | Twenty-four hour intra-arterial infusion of 5-fluorouracil,cisplatin,and leucovorin is more effective than 6-hour infusion for advanced hepatocellular carcinoma显示文摘AIM: To evaluate the time dependence of intra-arterial 5-fluorouracil (5-FU) therapy for advanced hepatocellular carcinoma (aHCC). METHODS: Thirty-seven adult Japanese patients who had aHCC and liver cirrhosis were treated with combined intra-arterial 5-FU, cisplatin (CDDP), and leucovorin (LV). The Japan Integrated Staging score (JIS score) of each patient was 3 or more. The patients were divided into two groups, after which the 15 patients in group S were treated with 6-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 4 h) and the 22 patients in group L were treated with 24-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 22 h). Continuous infusion chemotherapy was performed via the proper hepatic artery every 5 d for 4 wk using an implanted drug reservoir. RESULTS: The percentages of patients with a partial response after 4 wk of chemotherapy were 6.7% in group S and 31.8% in group L. The survival of group L was significantly better than that of group S, with the median survival time being 496 d in group L and 226 d in group S (P < 0.05). CONCLUSION: Continuous 24-h intra-arterial infusion is more effective for aHCC and can markedly prolong survival time as compared to 6-h infusion. | Hidenari Nagai Masahiro Kanayama Katsuya Higami Kouichi Momiyama Akiko Ikoma Naoki Okano Katsuhiko Matsumaru Manabu Watanabe Koji Ishii Yasukiyo Sumino Kazumasa Miki | 2007 | World Journal of Gastroenterology2007，13，2： | 6 |
| 3 | 商业车辆第二代EE传动自动机械变速箱(AMT)的优越性显示文摘自动机械变速箱在 1 985年起由 Hino开发的 EE-传动 ,其特点是气动冲程控制、油喷射螺旋弹簧型离合器 [1 ][2 ]* 。由于在日本自动变速器 ( AT)市场扩大而为城市大客车建造了该装置。本文介绍了装于中型货车的第二代 EE传动 ,其特徵是采用液压控制、油喷射离合器。该装置直接通过离合器片压力使起动平稳。同时能快速换档 ,变速不带离合冲击而使压力降低。它将在市场与 1 990年出现的完善的电子控制 ( ECT)具有变扭器的自动变速器 ( AT)相竞争。在日本商业车辆的自动变速器开始发展于 1 990的前半期。 1 985年 Hino EE传动投放市场。同时期在日本自动变速器的轿车超过总轿车数量的一半达到 5 7%。应为 AT用于商业车辆准备市场。已经扩大市场主要在城市大客车中采用 EE传动。许多公共运输服务的客户支持把 AT延伸至自动机械变速器 ( AMT) [3]。在这种意义上 ,装有 EE传动的城市客车仍占主导地位。在 1 987年 ,另外的制造商的一种 AMT投放市场。伴随着由于较低的燃油经济性使液压自动变速器 ( HAT)不能实现商业用途。随着大众化的 AT轿车采用电子控制自动变速器 ( ECT)的出现而快速发展的同时 ,一种真正的商业车辆的 AT时代当用于商业车辆的 HAT也用电子控制改进时 ,HAT和 AMT竞争共存。HAT和 AMT的优点将? | Fujio Momiyama koji Harada Masahiro kanen Yasutoshi | 2001 | 传动技术2001，15，4： | 3 |
| 4 | Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy,and tumor-targeting S.typhimurium A1-R is superior to first-line chemotherapy显示文摘Cancer of unknown primary(CUP)is a recalcitrant disease with poor prognosis because it lacks standard first-line therapy.CUP consists of diverse malignancy groups,making personalized precision therapy essential.The present study aimed to identify an effective therapy for a CUP patient using a patient-derived orthotopic xenograft(PDOX)model.This paper reports the usefulness of the PDOX model to precisely identify effective and ineffective chemotherapy and to compare the efficacy of S.typhimurium A1-R with first-line chemotherapy using the CUP PDOX model.The present study is the first to use a CUP PDOX model,which was able to precisely distinguish the chemotherapeutic course.We found that a carboplatinum(CAR)-based regimen was effective for this CUP patient.We also demonstrated that S.typhimurium A1-R was more effective against the CUP tumor than first-line chemotherapy.Our results indicate that S.typhimurium A1-R has clinical potential for CUP,a resistant disease that requires effective therapy. | Kentaro Miyake Tasuku Kiyuna Masuyo Miyake Kei Kawaguchi Sang Nam Yoon Zhiying Zhang Kentaro Igarashi Sahar Razmjooei Sintawat Wangsiricharoen Takashi Murakami Yunfeng Li Scott D.Nelson Tara A.Russell Arun S.Singh Yukihiko Hiroshima Masashi Momiyama Ryusei Matsuyama Takashi Chishima Shree Ram Singh Itaru Endo Fritz C.Eilber Robert M.Hoffman | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 5 | Associations between serum lipopmtein(a)levels and the severity of coronary and aortic athemsclemsis显示文摘 | Momiyama Y 0hmori R Fayad ZA et a1 | 2012 | At Ilemsclerosis2012，222，1： | 1 |
| 6 | Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease显示文摘 | Ohmori R Momiyama Y Kato R | 2005 | J Am Coll Cardiol2005，46，2： | 1 |
| 7 | Prognostic value of plasma high-sensitivity C-reactive protein levels in Japanese patients with stable coronary artery disease:The Japan NCVC-Collaborative Inflammation Cohort(JNIC)Study显示文摘 | Momiyama Y Kawagnchi A Kajiwara I | 2009 | Atherosclerosis2009，204，1： | 1 |
| 8 | Potential functional neural repair with grafted neural stem cells of early embryonic neuroepithelial origin 显示文摘 | Uchida K Momiyama T Okano H | 2005 | Neurosci Res2005，52，3： | 1 |
| 9 | Associations between serum resistin levels and resistance, inflammation, and coronary artery disease 显示文摘 | Ohmori R Momiyama Y Kato R | 2005 | Am Coil Cardiol2005，46，2： | 1 |
| 10 | Association between osteoprotegerin gene polymorphism and coronary artery disease in Japanese men显示文摘 | Ohmori R Momiyama Y Taniguchi H | 2006 | Atherosclerosis2006，187，2： | 1 |
| 11 | As sociations between serum resistin levels and insulin re sistance, inflammation, and coronary artery disease 显示文摘 | OHMORI R MOMIYAMA Y KATO R | 2005 | J Am CollCardiol2005，46，： | 1 |
| 12 | Function of MMP-7 in colorectal cancer显示文摘 | Ichikawa Y Ishikawa T Momiyama N | 2003 | Nihon Rinsho2003，61，7： | 1 |
| 13 | Serum Resistin Levels and Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention显示文摘 | Momiyama Y Ohmori R Uto-Kondo H | 2010 | J Atheroscler Thromb2010，17，6： | 1 |
| 14 | Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis显示文摘 | Momiyama Y Ohmori R Fayad ZA | 2010 | J Atheroscler Thromb2010，17，5： | 1 |
| 15 | Association between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis显示文摘 | Momiyama Y Ohmori R Fayad ZA | 2010 | J Atheroscler Thromb2010，17，5： | 1 |
| 16 | Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques: a 2-year follow-up by noninvasive MRI显示文摘 | Yonemura A Momiyama Y Fayad ZA | 2009 | Eur J Cardiovasc Prev Rehabil2009，16，： | 1 |
| 17 | Simple synthesis of α- hydroxyamino carbonyl compounds : New scope of the nitroso Aldol reaction 显示文摘 | Momiyama N Yamamoto H | 2002 | Org Lett2002，4，： | 1 |
| 18 | Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease 显示文摘 | Ohmori R Momiyama Y Kato R | 2005 | J Am Coll Cardiol2005，46，2： | 1 |
| 19 | Association between osteoprotegerin gene polymorphism and coronary artery disease in Japanese men 显示文摘 | Ohmori R Momiyama Y Taniguchi H | 2006 | Atherosclerosis2006，187，1： | 1 |
| 20 | Assoeiations of plasma creactive protein levels with the presence and extent of coronary stenosis in patients with stable coronary artery disease显示文摘 | Taniguchi H Momiyama Y Ohmori R | 2012 | Atheroselerosis2012，178，1： | 1 |
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